山本健二 (Kenji Yamamoto) - マイポータル

基本情報

所属: 九州大学大学院薬学研究院特任教授

学位: 薬学博士(九州大学)
薬学修士

J-GLOBAL ID: 200901046645006257
researchmap会員ID: 1000042419

外部リンク: http://210.233.60.66/~protease/

研究キーワード

研究分野

委員歴

受賞

2001年

ホルツァー賞
2001年

Holzer Award

MISC

198

Impaired chemotaxis and cell adhesion due to decrease in wide range of cell surface receptors in cathepsin E-deficient macrophages.

J. Biochem. inpress 2009年
Development of systemin in vitro evolution and its application to generation of peptide aptamer-based inhibitors of cathepsin E.

J. Mol. Biol. inpress 2009年
Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system

Yutaka Ishida, JinPing Hu, Eiko Sakai, Tomoko Kadowaki, Kenji Yamamoto, Takayuki Tsukuba, Yuzo Kato, Koji Nakayama, Kuniaki Okamoto

ARCHIVES OF ORAL BIOLOGY 53(6) 538-544 2008年6月
Association of cathepsin E deficiency with the increased territorial aggressive response of mice

Naoki Shigematsu, Takaichi Fukuda, Tsuneyuki Yamamoto, Tsuyoshi Nishioku, Taku Yamaguchi, Masaru Himeno, Keiichi I. Nakayama, Takayuki Tsukuba, Tomoko Kadowaki, Kuniaki Okamoto …

JOURNAL OF NEUROCHEMISTRY 105(4) 1394-1404 2008年5月
An immunohistochemical study on a unique colocalization relationship between substance P and GABA in the central nucleus of amygdala

Naoki Shigematsu, Kenji Yamamoto, Shun Higuchi, Takaichi Fukuda

BRAIN RESEARCH 1198 55-67 2008年3月
Gene expression profiling of mammary glands of cathepsin E-deficient mice compared with wild-type littermates

Tomoyo Kawakubo, Atsushi Yasukochi, Takayuki Tsukubal, Tomoko Kadowaki, Kenji Yamamoto

BIOCHIMIE 90(2) 396-404 2008年2月
Cathepsin E prevents tumor growth and metastasis by catalyzing the proteolytic release of soluble TRAIL from tumor cell surface

Tomoyo Kawakubo, Kuniaki Okamoto, Jun-Ichi Lwata, Masashi Shin, Yoshiko Okamoto, Atsushi Yasukochi, Keiichi I. Nakayama, Tomoko Kadowaki, Takayuki Tsukuba, Kenji Yamamoto

CANCER RESEARCH 67(22) 10869-10878 2007年11月
Differential regulation of the nature and functions of dendritic cells and macrophages by cathepsin E

Hiroe Kakehashi, Tsuyoshi Nishioku, Takayuki Tsukuba, Tomoko Kadowaki, Seiji Nakamura, Kenji Yamamoto

JOURNAL OF IMMUNOLOGY 179(9) 5728-5737 2007年11月
Association of cathepsin E with tumor growth arrest through angiogenesis inhibition and enhanced immune responses

Masashi Shin, Tomoko Kadowaki, Jun-ichi Iwata, Tomoyo Kawakubo, Noriko Yamaguchi, Ryosuke Takii, Takayuki Tsukuba, Kenji Yamamoto

BIOLOGICAL CHEMISTRY 388(11) 1173-1181 2007年11月
Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases

Sachiko Kanaji, Yoko Tanaka, Yasuhisa Sakata, Kohei Takeshita, Kazuhiko Arima, Shoichiro Ohta, Elizabeth J. Hansell, Conor Caffrey, Jeremy C. Mottram, Jonathan Lowther …

FEBS LETTERS 581(22) 4260-4264 2007年9月
A role for gingipains in cellular responses and bacterial survival in Porphyromonas gingivalis-infected cells

Tomoko Kadowaki, Ryosuke Takii, Kumiko Yamatake, Tomoyo Kawakubo, Takayuki Tsukuba, Kenji Yamamoto

FRONTIERS IN BIOSCIENCE-LANDMARK 12 4800-4809 2007年9月
Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide.

Eiko Sakai, Mariko Naito, Keiko Sato, Hitoshi Hotokezaka, Tomoko Kadowaki, Arihide Kamaguchi, Kenji Yamamoto, Kuniaki Okamoto, Koji Nakayama

Journal of bacteriology 189(11) 3977-86 2007年6月
Role for gingipains in Porphyromonas gingivalis traffic to phagolysosomes and survival in human aortic endothelial cells

Kumiko Yamatake, Maki Maeda, Tomoko Kadowaki, Ryosuke Takii, Takayuki Tsukuba, Takashi Ueno, Eiki Kominami, Sadaki Yokota, Kenji Yamamoto

INFECTION AND IMMUNITY 75(5) 2090-2100 2007年5月
Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages

Michiyo Yanagawa, Takayuki Tsukuba, Tsuyoshi Nishioku, Yoshiko Okamoto, Kuniaki Okamoto, Ryosuke Takii, Yoshihiro Terada, Keiichi I. Nakayama, Tomoko Kadowaki, Kenji Yamamoto

JOURNAL OF BIOLOGICAL CHEMISTRY 282(3) 1851-1862 2007年1月
Selection-by-function: efficient enrichment of cathepsin E inhibitors from a DNA library

Mohammed Naimuddin, Koichirou Kitamura, Yasunori Kinoshita, Yoko Honda-Takahashi, Marina Murakami, Masato Ito, Kenji Yamamoto, Kazunori Hanada, Yuzuru Husimi, Koichi Nishigaki

JOURNAL OF MOLECULAR RECOGNITION 20(1) 58-68 2007年1月
Cathepsin E-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface Toll-like receptors

Takayuki Tsukuba, Shinya Yamamoto, Michiyo Yanagawa, Kuniaki Okamoto, Yoshiko Okamoto, Keiichi I. Nakayamas, Tomoko Kadowaki, Kenji Yamamoto

JOURNAL OF BIOCHEMISTRY 140(1) 57-66 2006年7月
Novel non-uniform distribution of serotonin transporter in the mouse hippocampus and neocortex revealed by N- and C-terminal domain-specific immunohistochemistry

N Shigematsu, K Yamamoto, S Hiyuchi, T Fukuda

BRAIN RESEARCH 1075 110-116 2006年2月
エンドソーム系による細胞代謝と生体応答制御.

福岡医雑誌 97 207-209 2006年
カテプシン

Medical Tribune 39 32 2006年
Gingipains inactivate a cell surface ligand on Porphyromonas gingivalis that induces TLR2- and TLR4-independent signaling

M Kishimoto, A Yoshimura, M Naito, K Okamoto, K Yamamoto, DT Golenbock, Y Hara, K Nakayama

MICROBIOLOGY AND IMMUNOLOGY 50(4) 315-325 2006年

もっとみる

書籍等出版物

酵素ハンドブック（分担執筆）

朝倉書店 2008年
現代歯科薬理学（第4版）（加藤, 篠田, 大谷編）（分担執筆）

医歯薬出版 2005年
怖い怖い歯周病

タンパク質分解の不思議第15回大学と科学公開シンポジウム（クバプロ） 2001年
歯周病とプロテアーゼー歯周病原細菌のヘムおよびアミノ酸獲得機序ー

タンパク質分解：分子機構と細胞機能シュプリンガー・フェアラーク社 2000年
ノックアウトマウスによるカテプシン機能の解析

(シュプリンガー・フェアラーク東京)神経難病の分子機構 2000年
Arg-gingipain and Lys-gingipain : A Novel Class of Cysteine Proteinases.

Proteases-New Perspectives (Turk, V., ed.) Birkh(]E88D2[)user Verlag, Basel 1999年
Cathepsin E and Cathepsin D.

Proteases-New Perspectives (Turk, V., ed.) Birkh(]E88D2[)user Verlag, Basel 1999年
現代歯科薬理学（第3版）（小椋, 加藤, 篠田編）（分担執筆）

医歯薬出版 1998年
ノックアウトマウス･データブック,Molecular Medicine

中山書店 1997年
Involvement of cathepsin E in modulating endosomal/lysosomal proteolytic system. Dynamic Aspects of Lysosomal/vacuolar System

1997年
Synthesis and processing of the monomeric and dimeric forms of human cathepsin E expressed in Chinese hamster ovary cells. In Proteolysis in Cell Functions

IOS Press, Amsterdam 1997年
Biosynthesis and trafficking of cathepsin E. In Proteolysis in Cell Functions

IOS Press, Amsterdam 1997年
Structural characterization of pathogenic cysteine proteinases from the oral bacterium Porphyromonas gingivalis. In Proteolysis in Cell Functions

IOS Press, Amsterdam 1997年
Biological roles of a novel class of cysteine proteinases from Porphyromonas gingivalis in periodontal disease progression. In Medical Aspects of Proteases and Protease Inhibitors

IOS Press, Amsterdam 1997年
Possible roles of N-linked olicosaccharides on cathepsin E. In: Proteolysis in Cell Functions

IOS Press, Amsterdam, 1997年
現代の薬理学（田中潔編）（分担執筆）第3回全面改訂増補第18版

金原出版 1996年
Structure and function of a novel arginine-specific cysteine proteinase (argingipain) as a major periodontal pathogenic factor from Porphyromonas gingivalis. (共著)

Intracelluar Protein Catabolism(Plenum Press, New York) 1996年
Cathepsin E expressed in pancreatic cancer.

Aspartic Proteinases : Structure, Function,Biology, and Biomedical Implications (Plenum Press) 1995年
Comparison of biochemical properties of natural and recombinant cathepsin E (共著)

Aspartic Proteinases : Structure, Function, Biology, and Biomedical Implications (Plenum Press) 1995年
Increased expression and specific localization of cathepsins E and D in vulnerable brain regions of aged postischemic rats (共著)

Aspartic Proteinases : Structure, Function, Biology, and Biomedical Implications (Plenum Press) 1995年

もっとみる

山本健二

基本情報

研究キーワード

研究分野

委員歴

受賞

MISC

書籍等出版物

所属学協会

共同研究・競争的資金等の研究課題

メニュー