Manabu Nakashima

Profile Information

Affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University
: (Concurrent)Faculty of Pharmaceutical Sciences

Degree: MD. PhD.(Kyushu University)

Researcher number: 50198074
J-GLOBAL ID: 200901014984398149
researchmap Member ID: 1000042559

Research Interests

Research Areas

Research History

Apr, 2007

福岡大学薬学部教授
Apr, 2004 - Mar, 2007

福岡大学薬学部助教授
Apr, 2001 - Mar, 2004

九州大学助手生体防御医学研究所付属感染防御センタ−に配置換
Apr, 1987 - Mar, 2001

九州大学生体防御医学研究所・文部教官助手
Mar, 1993 - Aug, 1993

アメリカ国フィラデルフィア州ウイスター研究所訪問研究員
Feb, 1990 - Jan, 1992

アメリカ国フィラデルフィア州ウイスター研究所訪問研究員
Apr, 1986 - Mar, 1987

九州大学医学部付属病院（基礎系医員）
Oct, 1985 - Mar, 1986

九州大学生体防御医学研究所・研究生
Apr, 1984 - Sep, 1985

佐世保市立総合病院内科医
Oct, 1983 - Mar, 1984

国立療養所長崎病院内科医師
Jun, 1983 - Oct, 1983

長崎大学医学部付属病院医員
Jun, 1981 - May, 1983

長崎大学医学部付属病院医員（研修医）

Education

- 1981

医学科, Faculty of Medicine, Nagasaki University

Papers

Assesment of Anticancer Drug Effects on Pancreatic Cancer Cells under Glucose-depleted Conditions using Intracellular and Extracellular Amino Acid Metabolomics

Ryoko Tomita, Kenchiro Todoroki, Tadashi Hayama, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta

Biological and Pharmaceutical Bulletin, 41(2) 220-228, Feb, 2018 Peer-reviewed
miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment

Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Yasukochi A, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M

Molecular Carcinogenesis, 57(2) 295-308, 2018 Peer-reviewed
In vitro anti-inflammatory effects of the phenylbutyric acid metabolite phenylacetyl glutamine

Mai Hazekawa, Kazuhiko Ono, Takuya Nishinakagawa, Tomoyo Kawakubo-Yasukochi, Manabu Nakashima

Biological and Pharmaceutical Bulletin, 41(6) 961-966, 2018 Peer-reviewed
Assessment of cytotoxicity of imatinib for oral squamous cell carcinoma by a real-time cell analysis system

Hazekawa M, Morioka M, Nishinakagawa T, Kawakubo-Yasukochi T, Nakamura S, Nakashima M

eJBio, 13(1) 56-62, 2017 Peer-reviewed
Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

Hazekawa M, Hideshima Y, Ono K, Nishinakagawa T, Kawakubo-Yasukochi T, Takatani-Nakase T, Nakashima M

Ex Ther Med., 14(5) 4349-4355, 2017 Peer-reviewed
Orally administered sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium-induced colitis in mice

Ono K, Nimura S, Hideshima Y, Nabeshima K, Nakashima M

Ex Ther Med., 14(6) 5485-5490, 2017 Peer-reviewed
Amino Acid Metabolomics Using LC-MS/MS: Assessment of Cancer-Cell Resistance in a Simulated Tumor Microenvironment

Ryoko Tomita, Kenichiro Todoroki, Hiroshi Maruoka, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta

ANALYTICAL SCIENCES, 32(8) 893-900, Aug, 2016 Peer-reviewed
Effect of collagen type I or human fibronectin on imatinib cytotoxicity in oral squamous cell carcinoma

Morioka M, Hazekawa M, Kawakubo-Yasukochi T, Nishinakagawa T, Nakamura S, Nakashima M

Pharmacol Pharm, 7 255-263, 2016 Peer-reviewed
Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination

Morioka M, Kawakubo-Yasukochi T, Hayashi Y, Hazekawa M, Nishinakagawa T, Ono K, Kawano S, Nakamura S, Nakashima M

J Oral Biosci, 58(4) 180-184, 2016 Peer-reviewed
The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes

Kawakubo-Yasukochi T, Morioka M, Hayashi Y, Nishinakagawa T, Hazekawa M, Kawano, S, Nakamura S, Nakashima M

J Oral Biosci, 58 33-38, 2016 Peer-reviewed
Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism

Motoyuki Kohjima, Munechika Enjoji, Ryoko Yada, Tsuyoshi Yoshimoto, Tsukasa Nakamura, Kunitaka Fukuizumi, Nobuyoshi Fukushima, Yusuke Murata, Manabu Nakashima, Masaki Kato …

LIVER INTERNATIONAL, 35(3) 1095-1102, Mar, 2015 Peer-reviewed
Enhanced Antitumor Effects of Novel Intracellular Delivery of an Active Form of Menaquinone-4, Menahydroquinone-4, into Hepatocellular Carcinoma

Shuichi Setoguchi, Daisuke Watase, Kazuhisa Matsunaga, Misa Matsubara, Yohei Kubo, Mariko Kusuda, Nami Nagata-Akaho, Munechika Enjoji, Manabu Nakashima, Morishige Takeshita …

CANCER PREVENTION RESEARCH, 8(2) 129-138, Feb, 2015 Peer-reviewed
Assessment of the Efficacy of Anticancer Drugs by Amino Acid Metabolomics Using Fluorescence Derivatization-HPLC

Ryoko Tomita, Kenichiro Todoroki, Kazuyuki Machida, Sho Nishida, Hiroshi Maruoka, Hideyuki Yoshida, Toshihiro Fujioka, Manabu Nakashima, Masatoshi Yamaguchi, Hitoshi Nohta

ANALYTICAL SCIENCES, 30(7) 751-758, Jul, 2014 Peer-reviewed
Sodium 4-phenylbutyrate suppresses the development of dextran sulfate sodium- induced colitis in mice

Kazuhiko Ono, Satoshi Nimura, Takuya Nishinakagawa, Yuko Hideshima, Munechika Enjyoji, Kazuki Nabeshima, Manabu Nakashima

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 7(3) 573-578, Mar, 2014 Peer-reviewed
Fully automated reagent peak-free liquid chromatography fluorescence analysis of highly polar carboxylic acids using a column-switching system and fluorous scavenging derivatization

Kenichiro Todoroki, Hiroki Hashimoto, Kazuyuki Machida, Miki Itoyama, Tadashi Hayama, Hideyuki Yoshida, Hitoshi Nohta, Manabu Nakashima, Masatoshi Yamaguchi

JOURNAL OF SEPARATION SCIENCE, 36(2) 232-238, Jan, 2013 Peer-reviewed
Analysis of cell cycle arrest and apoptosis induced by RCAS1

Takuya Nishinakagawa, Sho Fujii, Tetsuya Nozaki, Tatsuhiro Maeda, Kazuyuki Machida, Munechika Enjoji, Manabu Nakashima

Int . J . Mol . Med, 25 717-722, 2010 Peer-reviewed
A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P+A53T transgenic mice

Kazuhiko Ono, Miyuki Ikemoto, Takeshi Kawarabayashi, Masaki Ikeda, Takuya Nishinakagawa, Masato Hosokawa, Mikio Shoji, Mitsuo Takahashi, Manabu Nakashima

PARKINSONISM & RELATED DISORDERS, 15(9) 649-654, Nov, 2009 Peer-reviewed
The state of cholesterol metabolism in the liver of patients with primary biliary cirrhosis: the role of MDR3 expression

Munechika Enjoji, Ryoko Yada, Tatsuya Fujino, Tsuyoshi Yoshimoto, Masayoshi Yada, Naohiko Harada, Nobito Higuchi, Masaki Kato, Motoyuki Kohjima, Akinobu Taketomi …

HEPATOLOGY INTERNATIONAL, 3(3) 490-496, Sep, 2009 Peer-reviewed
Impact of cholesterol metabolism and the LXR alpha-SREBP-1c pathway on nonalcoholic fatty liver disease

Makoto Nakamuta, Tatsuya Fujino, Ryoko Yada, Masayoshi Yada, Kenichiro Yasutake, Tsuyoshi Yoshimoto, Naohiko Harada, Nobito Higuchi, Masaki Kato, Motoyuki Kohjima …

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 23(5) 603-608, May, 2009
Early decline of the HCV core antigen can predict SVR in patients with HCV treated by Pegylated interferon plus ribavirin combination therapy

Tatsuya Fujino, Makoto Nakamuta, Yoko Aoyagi, Kunitaka Fukuizumi, Ryosuke Takemoto, Tsuyoshi Yoshimoto, Toshihiko Miyahara, Naohiko Harada, Hironori Sakai, Manabu Nakashima …

JOURNAL OF DIGESTIVE DISEASES, 10(1) 21-25, Feb, 2009

Books and Other Publications

パートナー機能形態学

NAKASHIMA Manabu, TAKANO Yukio, HONDA Kenji, MISHIMA Ken-Ichi, SAITO Ryo (Role: Joint author)

南江堂, Mar, 2013
薬系免疫学

植田正, 前仲勝美, 荒牧弘範, 黒木喜美子, 宗孝紀 (Role: Joint author, 127-150)

南江堂, Oct, 2007 (ISBN: 9784524402465)

Presentations

Detachment of Cell Sheet from Cell Culture Dishes by pre-coating of Thermoresponsive Side-Chain Crystalline Block Co-Polymer

Mai Hazekawa, Sho Hirai, Ryoko Nakano, Shigeru Yao, Manabu Nakashima

The 12th SPSJ International Polymer Conference, Dec 6, 2018, 高分子学会
側鎖結晶性ブロック共重合体を用いた新規な細胞培養基盤の開発とその評価

山口晃志, 佐藤圭奈子, 平井翔, 中野涼子, 関口博史, 八尾滋, 櫨川舞, 中島学

第56回高分子と水に関する討論会, Nov 29, 2018, 高分子学会
UPLC-UV分析によるアミノ酸メタボロミクス（2）

TOMITA Ryoko, KUROKI Yuki, TODOROKI Kenichiro, HAYAMA Tadashi, YOSHIDA Hideyuki, NAKASHIMA Manabu, NOHTA Hitoshi, YAMAGUCHI Masatoshi, FUJIOKA Toshihiro

日本分析化学会第66年会, Sep 11, 2017, 日本分析化学会
悪性中皮腫細胞に対するアミノ酸メタボロミクス

TANIGUCHI Kanae, TOMITA Ryoko, HAYAMA Tadashi, NABESHIMA, Kazuki, NAKASHIMA Manabu, FUJIOKA Toshihiro

The 35th Summer Seminar for Young Analytical Chemist in Kyushu, Jul 28, 2017, 九州分析化学若手の会・日本分析化学会九州支部
Amino Acid Metabolomics Analysis of PANC-1 Cells Cultured under Hypoglycemia Conditions

冨田陵子, 新納李那, 轟木堅一郎, 賀来祐美, 巴山忠, 吉田秀幸, 中島学, 能田均, 山口政俊, 藤岡稔大

日本薬学会第137年会, Mar 27, 2017
栄養飢餓状態で培養したPANC-1代謝に対するアミノ酸メタボロミクス解析

TOMITA Ryoko, TODOROKI Kenichiro, KAKU Yumi, HAYAMA Tadashi, YOSHIDA Hideyuki, NAKASHIMA Manabu, NOHTA Hitoshi, YAMAGUCHI Masatoshi, FUJIOKA Toshihiro

新アミノ酸分析研究会第6回学術講演会, Nov 4, 2016, 新アミノ酸分析研究会
Amino acid metabolomics of hypoxic and hypoglycemic colon cancer cells using LC-MS/MS

TOMITA Ryoko, NISHIDA Sho, HAYAMA Tadashi, TODOROKI Kenichiro, YOSHIDA Hideyuki, MARUOKA Hiroshi, NAKASHIMA Manabu, NOHTA Hitoshi, YAMAGUCHI Masatoshi, FUJIOKA Toshihiro

日本薬学会第135年会, Mar 27, 2015
PBA代謝産物のマウス炎症性サイトカイン産生に対する効果

Ono Kazuhiko, KUSUDA Mariko, HIDESHIMA Yuko, NISHINAKAGAWA Takuya, ENJOJI Munechika, NAKASHIMA Manabu

薬学会第134年会, Mar 30, 2014
PBA代謝産物のヒト炎症性サイトカイン産生に対する効果

秀島優子, 楠田真理子, 小野和彦, 西中川拓也, 遠城寺宗近, 高田二郎, 中島学

薬学会第134年会, Mar 30, 2014
Purification and characterization of the cytotoxic factor secreted by tumor cell line

NAKASHIMA Manabu

第72回日本癌学会学術総会, Oct 5, 2013
Amino acid metabolomics for tumor therapy assessment based on fluorescence derivatization-HPLC (3)

TOMITA Ryoko, NISHIDA Sho, MARUOKA Hiroshi, Todoroki Kenichiro, NAKASHIMA Manabu, NOHTA Hitoshi, YAMAGUCHI Masatoshi, YAMAGATA Kenji, FUJIOKA Toshihiro

The 133rd Annual Meeting of the Pharmaceutical Society of Japan, Mar 28, 2013
LC Determination with Fluorescence Detection of Organic Acids Using Fluorous Scavenging Derivatization Method and its Application of Urine Samples from Mouse Model of Disease

轟木堅一郎, 橋本裕輝, 森俊訓, 町田和之, 糸山美紀, 巴山忠, 吉田秀幸, 能田均, 中島学, 山口政俊

第9回次世代を担う若手のためのフィジカル・ファーマフォーラム（PPF2011）, Sep 12, 2011
Fluorous Scavenging Derivatization（FSD）法による病態モデルマウス尿中有機酸の蛍光誘導体化-HPLC 分析

MORI Toshinori, HASHIMOTO Hiroki, TODOROKI Kenichiro, MACHIDA Kazuyuki, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, NAKASHIMA Manabu, YAMAGUCHI Masatoshi

第48回化学関連支部合同九州大会, Jul 9, 2011
蛍光誘導体化-HPLC法による神経芽細胞腫のアミノ酸メタボロミクス

KONDO Shinji, ISOHAMA Yukari, SAKAMOTO Yukiko, TODOROKI Kenichiro, MACHIDA Kazuyuki, TOMITA Ryoko, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, NAKASHIMA Manabu, YAMAGUCHI Masatoshi

第27回日本薬学会九州支部大会, Dec 11, 2010
Fluorous Scavenging Derivatization（FSD）法による高極性有機酸の蛍光誘導体化HPLC分析（2）-TCAサイクル中間体分析への適用-

HASHIMOTO Hiroki, NAITO Nobue, MORI Toshikuni, TODOROKI Kenichiro, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, YAMAGUCHI Masatoshi

フルオラス科学研究会第3回シンポジウム, Oct 8, 2010
Derivatives of vitamin K design to enhance Menahydroquinone-4 (MKH) accumulation in hepatocellular carcinoma (HCC) cells

KUSUDA Mariko, WATASE Daisuke, AKAHO Nami, MATSUNAGA Kazuhisa, NAKASHIMA Manabu, ENJOJI Munechika, KARUBE Yoshiharu, TAKATA Jiro

The 69th Annual Meeting of the Japanese Cancer Association, Sep 24, 2010
Fluorous Scavenging Derivatization法による試薬ピークの検出されない高極性有機酸の蛍光誘導体化HPLC分析(2)

NAITO Nobue, HASHIMOTO Hiroki, MORI Toshinori, TODOROKI Kenichiro, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, NAKASHIMA Manabu, YAMAGUCHI Masatoshi

第28回九州分析化学若手の会夏季セミナー, Jul 30, 2010
蛍光誘導体化-HPLC法による神経芽細胞腫メタボロミクス解析

KONDO Shinji, TOMITA Ryoko, TODOROKI Kenichiro, MACHIDA Kazuyuki, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, NAKASHIMA Manabu, YAMAGUCHI Masatoshi

第71回分析化学討論会, May 15, 2010
アミノ酸メタボロミクスを用いた抗癌剤の治療効果判定法の開発(2)

TOMITA Ryouko, TODOROKI Kenichiro, MACHIDA Kazuyuki, ITOYAMA Miki, HAYAMA Tadashi, YOSHIDA Hideyuki, NOHTA Hitoshi, NAKASHIMA Manabu, YAMAGUCHI Masatoshi

第130年会日本薬学会, Mar 28, 2010
Amino Acid Metabolomics Analysis of Tumor Cells for Visualization of Drug Therapeutic Effect

冨田陵子, 轟木堅一郎, 町田和之, 糸山美紀, 巴山忠, 吉田秀幸, 能田均, 中島学, 山口政俊

第26回日本薬学会九州支部大会, Dec 12, 2009

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