J-GLOBAL         Last updated: Apr 15, 2019 at 11:19
Nagasaki University
Graduate school of Engineering
Job title
Doctor of Agriculture(Kyushu University)

Research Areas


Academic & Professional Experience

Apr 2011
Professor, Graduate School of Engineering, Nagasaki University
 Associate Professor,Applied Chemistry,Faculty of Engineering,Nagasaki University
 Professor,Applied Chemistry,Faculty of Engineering,Nagasaki University
Jun 1990
Mar 1996
Assistant Professor, Faculty of Agriculture, Kyushu University
 Research Associate,Kyushu University


Graduate School, Division of Agriculture, Kyushu University
Faculty of Agriculture, Kyushu University

Awards & Honors

The Japan Bioscience, Biotechnology, and Agrochemistry; Society Award for Encouragement of Young Scientists

Published Papers

Unno H, Itakura S, Higuchi S, Goda S, Yamaguchi K, Hatakeyama T
Protein science : a publication of the Protein Society   28(4) 766-778   Apr 2019   [Refereed]
Unno H, Nakamura A, Mori S, Goda S, Yamaguchi K, Hiemori K, Tateno H, Hatakeyama T
Scientific reports   8(1) 11516   Aug 2018   [Refereed]
Ca2+-Independent Carbohydrate-Recognition of the C-Type Lectins, Spl-1 and Spl-2, from the Bivalve Saxidomus Purpuratus and their Dimerization Properties
Higuchi Shuhei, Unno Hideak, Goda Shuichiro, Hatakeyama Tomomitsu
PROTEIN SCIENCE   27 136-137   Nov 2018   [Refereed]
Hatakeyama T, Ichise A, Unno H, Goda S, Oda T, Tateno H, Hirabayashi J, Sakai H, Nakagawa H
Protein science : a publication of the Protein Society   26(8) 1574-1583   Aug 2017   [Refereed]
Nagao T, Masaki R, Unno H, Goda S, Hatakeyama T
Bioscience, biotechnology, and biochemistry   80(10) 1966-1969   Oct 2016   [Refereed]
Unno H, Matsuyama K, Tsuji Y, Goda S, Hiemori K, Tateno H, Hirabayashi J, Hatakeyama T
Scientific reports   6 29135   Jul 2016   [Refereed]
Crystal structure of a novel Ca2+-dependent lectin GJL-I from the sea anemone Gyractis japonica and its carbohydrate-recognition mechanism
Nakamura Azusa, Unno Hideaki, Goda Shuichiro, Hatakeyama Tomomitsu
PROTEIN SCIENCE   25 158   Oct 2016   [Refereed]
Hatakeyama T, Higashi E, Nakagawa H
Toxicon : official journal of the International Society on Toxinology   108 46-52   Dec 2015   [Refereed]
Structure and carbohydrate-binding properties of a C-type lectin SPL with novel carbohydrate-recognition motifs
Itakura Shuhei, Unno Hideaki, Goda Shuichiro, Hatakeyama Tomomitsu
PROTEIN SCIENCE   25 154-155   Oct 2016   [Refereed]
Moriuchi H, Unno H, Goda S, Tateno H, Hirabayashi J, Hatakeyama T
Biochimica et biophysica acta   1850(7) 1457-1465   Jul 2015   [Refereed]
Hatakeyama T, Ichise A, Yonekura T, Unno H, Goda S, Nakagawa H
Toxicon : official journal of the International Society on Toxinology   94 8-15   Feb 2015   [Refereed]
Unno H, Goda S, Hatakeyama T.
Journal of Biological Chemistry   289(18) 12805-12812   May 2014   [Refereed]
Hatakeyama Tomomitsu, Goda Shuichiro, Unno Hideaki
TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY   28(161) E55-E60   May 2016   [Refereed]
Kato Y, Kochi K, Unno H, Goda S, Hatakeyama T
Bioscience, biotechnology, and biochemistry   78(11) 1906-1909   Nov 2014   [Refereed]
Hisamatsu K, Nagao T, Unno H, Goda S, Hatakeyama T.
Biochimica et Biophysica Acta - General Subjects   1830(8) 4211-4217   Aug 2013   [Refereed]
Goda S, Sadakata H, Unno H, Hatakeyama T.
Bioscience, Biotechnology and Biochemistry   77(3) 679-681   Mar 2013   [Refereed]
Alteration of the carbohydrate-binding specificity of the C-type lectin CEL-I by site-directed mutagenesis
Moriuchi Hiromi, Unno Hideaki, Goda Shuichiro, Hatakeyama Tomomitsu
GLYCOBIOLOGY   24(11) 1140-1141   Nov 2014   [Refereed]
Unno H, Hisamatsu K, Nagao T, Tateya Y, Matsumoto N, Goda S, Hatakeyama T.
Acta Crystallographica Section F: Structural Biology and Crystallization Communications   69(4) 416-420   Apr 2013   [Refereed]
Expression and characterization of the recombinant lectin SUL-1 derived from the venom of the sea urchin Toxopneustes pileolus
Ichise Ayaka, Unno Hideaki, Goda Shuichiro, Nakagawa Hideyuki, Hatakeyama Tomomitsu
GLYCOBIOLOGY   24(11) 1141   Nov 2014   [Refereed]
Hatakeyama T, Ishimine T, Baba T, Kimura M, Unno H, Goda S.
Protein and Peptide Letters   20(7) 796-801   Jul 2013   [Refereed]
Hatakeyama T, Karino R, Terai Y, Kimura M, Unno H, Goda S.
Bioscience, Biotechnology and Biochemistry   76(10) 1999-2001   Oct 2012   [Refereed]
Hatakeyama T
Methods in molecular biology (Clifton, N.J.)   1200 165-171   2014   [Refereed]
Niidome T, Matsuyama N, Kunihara M, Hatakeyama T, Aoyagi H.
Bulletin of the Chemical Society of Japan   78(3) 473-476   2005   [Refereed]
Shiba K, Hatakeyama T.
Polymer Preprints, Japan   54(2)    2005   [Refereed]
Property and antibacterial activity of dendritic and linear cationic peptides
Aoyagi Haruhiko, Hirano Akira, Niidome Takuro, Hatakeyama Tomomitsu
Peptide Revolution: Genomics, Proteomics & Therapeutics   970-971   2004   [Refereed]
Satoh F, Nakagawa H, Yamada H, Nagasaka K, Nagasaka T, Araki Y, Tomihara Y, Nozaki M, Sakuraba H, Ohshima T, Hatakeyama T, Aoyagi H.
Journal of Natural Toxins   11(4) 297-304   2002   [Refereed]
Niidome T, Urakawa M, Ohmori N, Hatakeyama T, Wada A, Hirayama T, Aoyagi H.
Proceedings of the Controlled Release Society   (26) 503-504   1999   [Refereed]
Oda T, Shinmura N, Nishioka Y, Komatsu N, Hatakeyama T, Muramatsu T.
Journal of Biochemistry   125(4) 713-720   1999   [Refereed]
Niidome T, Anzai S, Sonoda J, Tokunaga Y, Nakahara M, Hatakeyama T, Aoyagi H.
Journal of Peptide Science   5(7) 298-305   1999   [Refereed]
Hatakeyama T, Kamine T, Konishi Y, Kuwahara H, Niidome T, Aoyagi H.
Bioscience, Biotechnology and Biochemistry   63(7) 1312-1314   1999   [Refereed]
Yoshida K, Ohmori N, Mukai Y, Niidome T, Hatakeyama T, Aoyagi H.
Journal of Peptide Science   5(8) 360-367   1999   [Refereed]
Ohmori N, Niidome T, Hatakeyama T, Mihara H, Aoyagi H.
Journal of Peptide Research   51(2) 103-109   1998   [Refereed]
Hatakeyama T.
Nippon Nogeikagaku Kaishi   71(11) 1147-1152   1997   [Refereed]
Hirayama T, Yahiro K, Kimura M, Okamoto K, Padilla P.I, Wada A, Niidome T, Hatakeyama T, Aoyagi H.
Japanese Journal of Medical Science and Biology   50(4-5) 198-199   1997   [Refereed]
Hatakeyama T, Kuwahara H, Sato T, Niidome T, Aoyagi H, Fujisawa T.
Japanese Journal of Medical Science and Biology   50(4-5)    1997   [Refereed]
Hatakeyama T, Kohzaki H, Yamasaki N.
Analytical Biochemistry   207(2)    1992   [Refereed]
Kimura M, Arndt E, Kromer W, Kimura J, Hatakeyama T, Hatakeyama T.
Journal of Protein Chemistry   7(3) 248-249   1988   [Refereed]


Ueno Mikinori, Yamanishi Tomohiro, Hatakeyama Tomomitsu, Yamaguchi Kenichi, Oda Tatsuya
Japanese Journal of Food Chemistry and Safety   20(3) 196-202   2013
Lycopene existing in tomato is a nonprovitamin carotenoid with potent antioxidant properties. In addition to the antioxidant activities, lycopene is know to show anti-inflammatory effects through the inhibition of secretion of proinflammatory agen...
Seibutsu Butsuri   49(2) 75-79   Mar 2009
CEL-III is a Ca2+-dependent hemolytic lectin isolated from the sea cucumber Cucumaria echinata. X-ray crystallographic analysis revealed that CEL-III is composed of two ricin-like carbohydrate-binding domains (domain 1/2) and an ...
Nihon Kessho Gakkaishi   48(4) 290-295   Aug 2006
CEL-III is a Ca2+-dependent animal lectin from the sea cucumber, Cucumaria echinata, which shows binding specificity for galactose-containing carbohydrates and exhibits hemolytic and hemagglutinating activities. We have determin...
Ricin D-saccharide interaction as studied by ultraviolet difference spectroscopy
Yamasaki, N., Hatakeyama, T., and Funatsu, G.
J. Biochem.   98(6) 1555-1560   1985

Books etc

Sequence comparison and evolution of ribosomal proteins and their genes
Animal Lectins (G.R. Vasta and H. Ahmed, eds.)
CRC Press   2008   

Conference Activities & Talks

Cytotoxic mechanism of a GalNAc-specific C-type lectin CEL-I isolated from Holothuroidea (Cucumaria echinata) in MDCK cells
Characterization of recombinant CEL-IV, an invertebrate C-type lectin, expressed in Escherichia coli using an artificial synthetic gene
Characterization of the putative carbohydrate-binding domain of a dendritic cell surface receptor
X-ray crystallographic analysis of a complex of an α-galactoside specific C-type lectin CEL-IV and melibiose
Carbohydrate-recognition mechanism of an invertebrate C-type lectin CEL-IV revealed by X-ray crystallographic analysis


Analysis of oligomerization of hemolytic lectin by small angle X-ray scattering
X-ray structural analysis of Ca2+-dependent lectins from marine invertebrate

Research Grants & Projects

Study on Biologically Active Proteins of Marine Invertebrates
Project Year: 1989   
Study on Structure and Function of Protein Toxins
Project Year: 1989   
Development of New Functions of Biologically Acitive Peptides
Project Year: 1996