MISC

2003年9月

Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor epsilon 1 subunit

NEUROSCIENCE RESEARCH
  • T Kitamura
  • ,
  • M Mishina
  • ,
  • H Sugiyama

47
1
開始ページ
55
終了ページ
63
記述言語
英語
掲載種別
DOI
10.1016/S0168-0102(03)00171-8
出版者・発行元
ELSEVIER SCI IRELAND LTD

Neurogenesis continues throughout adulthood in the dentate gyrus in mice, and is regulated by environmental, endocrine, and pharmacological stimuli. Although running wheel exercises have been reported to enhance neurogenesis, details of molecule mechanisms of the enhancement are not well understood. We report here that the hippocampal neurogenesis is enhanced when wildtype mice are raised in cages with running wheels for 3 weeks, but the wheel exercise does not enhance the neurogenesis in mice lacking the NMDA receptor epsilon1 subunit. Brain-derived neurotrophic factor (BDNF) has been reported to affect neuronal cell proliferation and survival. We examined the BDNF levels in the hippocampi of wild-type and epsilon1 knockout mice, and found that the BDNF level was increased through wheel exercises in the wild-type but not in the knockout mice. The enhancement of neurogenesis by the wheel exercise was also found to be reversible: when the exercise-stimulated wild-type mice were returned to the environment without running wheels for 3 weeks, the neurogenesis was the same as that in the mice which had never experienced the exercise. These results suggest that the wheel exercise may activate NMDA receptors in the hippocampus, which in turn may enhance BDNF production and neurogenesis. (C) 2003 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

Web of Science ® 被引用回数 : 93

リンク情報
DOI
https://doi.org/10.1016/S0168-0102(03)00171-8
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000185296500007&DestApp=WOS_CPL

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