MISC

2004年1月

Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons

NEUROSCIENCE LETTERS
  • Y Inoue
  • ,
  • N Honkura
  • ,
  • A Kato
  • ,
  • S Ogawa
  • ,
  • H Udo
  • ,
  • K Inokuchi
  • ,
  • H Sugiyama

354
2
開始ページ
143
終了ページ
147
記述言語
英語
掲載種別
DOI
10.1016/j.neulet.2003.09.082
出版者・発行元
ELSEVIER SCI IRELAND LTD

In cultured rat hippocampal neurons, overexpression of Homer1a/Ves1-1S, an inducible protein upregulated by seizure or long-term potentiation, caused a reduction of punctate distribution of a postsynaptic protein Homer1c/Ves1-1L, without significant decrease in its total amount. Clusters of F-actin were also decreased. Treatments of cells with BDNF or a proteasome, inhibitor, which cause increase in the expression level of endogenous Homer1a, also resulted in the reduction of Homer1c puncta. These results indicate that the accumulation of Homer1a, either exogenously expressed or endogenously induced, caused redistribution and dispersion of postsynaptic clusters of Homer1c and F-actin, suggesting an important role of Homer1a in synaptic remodeling. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Web of Science ® 被引用回数 : 28

リンク情報
DOI
https://doi.org/10.1016/j.neulet.2003.09.082
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000188297700015&DestApp=WOS_CPL

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