2001年12月30日
Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins
Molecular Brain Research
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- 巻
- 97
- 号
- 2
- 開始ページ
- 186
- 終了ページ
- 189
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0169-328X(01)00303-5
The Vesl-1S/Homer-1a proteins are upregulated during seizure and long-term potentiation, but are rapidly degraded by ubiquitin-proteasome systems under normal conditions. We examined the distribution of Vesl-1S proteins in cultured hippocampal neurons. Application of proteasome inhibitors caused accumulation of Vesl-1S immunoreactivity in the neurons which showed a punctate distribution in the cortical regions of the cells, and these puncta were found to be juxtaposed with synaptophysin, a presynaptic, synapse-specific protein. These results suggest that Vesl-1S protein is synaptically targeted. © 2001 Elsevier Science B.V. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0169-328X(01)00303-5
- ISSN : 0169-328X
- PubMed ID : 11750075
- SCOPUS ID : 0035977412