2012年12月
Protection by a recombinant Mycobacterium bovis Bacillus Calmette-Guérin vaccine expressing Shiga toxin 2 B subunit against Shiga toxin-producing Escherichia coli in mice
Clinical and Vaccine Immunology
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 19
- 号
- 12
- 開始ページ
- 1932
- 終了ページ
- 1937
- 記述言語
- 英語
- 掲載種別
- 研究論文（学術雑誌）
- DOI
- 10.1128/CVI.00473-12
We have developed a novel vaccine against Shiga toxin (Stx)-producing Escherichia coli (STEC) infection using a recombinant Mycobacterium bovis BCG (rBCG) system. Two intraperitoneal vaccinations with rBCG expressing the Stx2 B subunit (Stx2B) resulted in an increase of protective serum IgG and mucosal IgA responses to Stx2B in BALB/c mice. When orally challenged with 103 CFU of STEC strain B2F1 (O91: H21), the immunized mice survived statistically significantly longer than the nonvaccinated mice. We suggest that intraperitoneal immunization with rBCG expressing Stx2B would be a potential vaccine strategy for STEC. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
- ID情報
-
- DOI : 10.1128/CVI.00473-12
- ISSN : 1556-6811
- ISSN : 1556-679X
- PubMed ID : 23035176
- SCOPUS ID : 84870419899