Kyosuke Sato

Profile Information

Affiliation: Assistant Professor, Faculty of Life Sciences, Faculty of Life Sciences(Basic medicine group),Kumamoto University, Kumamoto University

Degree: Doctor (Medicine)(Kumamoto University)

J-GLOBAL ID: 200901067579411711
researchmap Member ID: 1000044448

Research Areas

Papers

Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA).

Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Megumi Nagayama, Mio Hirayama-Kurogi, Sumio Ohtsuki, Norie Araki

Molecular & cellular proteomics : MCP, 18(2) 245-262, Feb, 2019 Peer-reviewed
Decomposition of the fluorescence spectra of two FAD molecules in electron-transferring flavoprotein from Megasphaera elsdenii

Kyosuke Sato, Yasuzo Nishina, Kiyoshi Shiga

Journal of Biochemistry, 154(1) 61-66, Jul, 2013 Peer-reviewed
Interaction between NADH and electron-transferring flavoprotein from Megasphaera elsdenii

Kyosuke Sato, Yasuzo Nishina, Kiyoshi Shiga

JOURNAL OF BIOCHEMISTRY, 153(6) 565-572, Jun, 2013 Peer-reviewed
8-アミノフラビンのメチル基置換による中点電位の変化 (共著)

佐藤恭介, 二科安三, 志賀潔

日本生理学雑誌, 74(3) 84-85, 2012
Quantum chemical study on midpoint potentials of 8-aminoflavin analogues (共著)

Sato K, Nishina Y, Shiga K

J. Physiol. Sci., 62(Suppl) S142-S142, 2012
Quantum chemical study on midpoint potentials of 8-aminoflavin analogues

Sato K, Nishina Y, Shiga K

J. Physiol. Sci. ,, 62(Suppl) S142-S142, 2012
8-置換フラビンの標準酸化還元電位と酸性度（共著）

佐藤恭介, 二科安三, 玉置春彦, 志賀潔

日本生理学雑誌, 73(1) 21-21, 2011
Effect of 2-methyl group on midpoint potential of acyl-CoA/enoyl-CoA （共著）

K. Sato, Y. Nishina, H. Tamaoki, C. Setoyama, K. Shiga

Journal of Physiological Sciences, 60(Suppl. 1) S109, 2010
アシルCoAの酸化還元能に対するメチル基の効果（共著）

佐藤恭介, 二科安三, 玉置春彦, 瀬戸山千秋, 志賀潔

日本生理学雑誌, 72(2) 48-48, 2010
FT-IR Spectroscopic Studies on the Molecular Mechanism for Substrate Specificity/Activation of Medium-Chain Acyl-CoA Dehydrogenase

Yasuzo Nishina, Kyosuke Sato, Haruhiko Tamaoki, Chiaki Setoyama, Retsu Miura, Kiyoshi Shiga

JOURNAL OF BIOCHEMISTRY, 146(3) 351-357, Sep, 2009 Peer-reviewed
Isomers in the excited state of electron-transferring flavoprotein from Megasphaera elsdenii: Spectral resolution from the time-resolved fluorescence spectra

Kyosuke Sato, Yasuzo Nishina, Kiyoshi Shiga, Fumio Tanaka

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 90(2) 134-140, Feb, 2008 Peer-reviewed
Donor-acceptor distance-dependence of photoinduced electron-transfer rate in flavoproteins

Fumio Tanaka, Haik Chosrowjan, Seiji Taniguchi, Noboru Mataga, Kyosuke Sato, Yasuzo Nishina, Kiyoshi Shiga

JOURNAL OF PHYSICAL CHEMISTRY B, 111(20) 5694-5699, May, 2007
A study on the reaction mechanism between electron-transferring flavoprotein and NADH using 8-CN-FAD (共著)

Sato K, Nishina Y, Shiga K

J. Physiol. Sci., 57(Suppl) S122-S122, 2007
FTIR spectroscopic study on molecular interaction of FAD encountered in the active site of flavoproteins

Nishina Y, Sato K, Tamaoki H, Setoyama C, Miura R, Shiga K

J. Physiol. Sci., 57(Suppl) S122-S122, 2007
Intramolecular and intermolecular perturbation on electronic state of FAD free in solution and bound to flavoproteins: FTIR spectroscopic study by using the C=O stretching vibrations as probes

Nishina Y, Sato K, Setoyama C, Tamaoki H, Miura R, Shiga K

Journal of Biochemistry, 142(2) 265-272, 2007 Peer-reviewed
Identification of the C = O stretching vibrations of FMN and peptide backbone by C-13-labeling of the LOV2 domain of Adiantum phytochrome3

Tatsuya Iwata, Dai Nozaki, Yoshiaki Sato, Kyosuke Sato, Yasuzo Nishina, Kiyoshi Shiga, Satoru Tokutomi, Hideki Kandori

BIOCHEMISTRY, 45(51) 15384-15391, Dec, 2006
Engineering the substrate specificity of porcine kidney D-Amino acid oxidase by mutagenesis of the "Active-Site Lid"

C Setoyama, Y Nishina, H Mizutani, Miyahara, I, K Hirotsu, N Kamiya, K Shiga, R Miura

JOURNAL OF BIOCHEMISTRY, 139(5) 873-879, May, 2006 Peer-reviewed
Three-dimensional structure of rat-liver acyl-CoA oxidase in complex with a fatty acid: Insights into substrate-recognition and reactivity toward molecular oxygen

K Tokuoka, Y Nakajima, K Hirotsu, Miyahara, I, Y Nishina, K Shiga, H Tamaoki, C Setoyama, H Tojo, R Miura

JOURNAL OF BIOCHEMISTRY, 139(4) 789-795, Apr, 2006 Peer-reviewed
Reaction of electron-transferring flavoprotein with D-lactate dehydrogenase and enoyl-CoA reductase (共著)

Sato K, Nishina Y, Shiga K

Journal of PHysiological Sciences, 56(Suppl) S121-S121, 2006
2P292 C=O Stretching Vibrations from FMN and Peptide Backbone Identified by ^<13>C Labeling in the LOV2 domain of Adiantum Phytochrome3

Iwata T., Nozaki D., Sato Y., Sato K., Nishina Y., Shiga K., Tokutomi S., Kandori H.

Seibutsu Butsuri, 45 S192, 2005

Misc.

Change in midpoint potential of 8-aminoflavin on metyl-displacement (jointly worked)

Sato K, Nishina Y, Shiga K

Journal of the Physiological Society of Japan, 74(3) 84-85, 2012
Standard redox potential and acidity of 8-substituted flavin "jointly worked"

Sato K, Nishina Y, Tamaoki H, Shiga K

Journal of the Physiological Society of Japan, 73(1) 21-21, 2011
Effect of methyl group on oxidation-reduction of acyl-CoA

Sato K, Nishina Y, Tamaoki H, Setoyama C, Shiga K

Journal of the Physiological Society of Japan, 72(2) 48-48, 2010
SUBSTRATE ACTIVATION MECHANISM OF BRANCHED-CHAIN ACYL-CoA DEHYDROGENASES: A STUDY USING ARTIFICIAL FLAVIN

Yasuzo Nishina, Kyosuke Sato, Chiaki Setoyama, Haruhiko Tamaoki, Yuka Tominaga, Maiko Horai, Hiromi Maeda, Kiyoshi Shiga

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 211-211, 2009
Introduction of density functional theory calculation to acyl-CoA dehydrogenase system.

Tanaka, T, Tamaoki, H, Nishina, Y, Shiga, K, Ohno, T, Hirotsu, K, Miura, R

Flavins and Flavoproteins 2005 (T.Nishino, R.Miura, M.Tanokura, K.Fukui eds.), ARchiTec Inc, Tokyo, 239-244, 2005
Purification of electron-transferring flavoprotein from Megasphaera elsdenii and binding of additional FAD with an unusual absorption spectrum

K Sato, Y Nishina, K Shiga

JOURNAL OF BIOCHEMISTRY, 134(5) 719-729, Nov, 2003
Hydrogen-bonding dynamics of free flavins in benzene and FAD in electron-transferring flavoprotein upon excitation

K Sato, Y Nishina, K Shiga, F Tanaka

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 70(2) 67-73, May, 2003
A blue-light-activated adenylyl cyclase mediates photoavoidance in Euglena gracilis

M Iseki, S Matsunaga, A Murakami, K Ohno, K Shiga, K Yoshida, M Sugai, T Takahashi, T Hori, M Watanabe

NATURE, 415(6875) 1047-1051, Feb, 2002
Crystallization and preliminary X-ray characterization of rat liver acyl-CoA oxidase

Y Nakajima, Miyahara, I, K Hirotsu, Y Nishina, K Shiga, C Setoyama, H Tamaoki, R Miura

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 57(11) 1680-1681, Nov, 2001
On the ligands in charge-transfer complexes of porcine kidney flavoenzyme D-amino acid oxidase in three redox states: A resonance Raman study

Y Nishina, K Sato, RW Shi, C Setoyama, R Miura, S Shiga

JOURNAL OF BIOCHEMISTRY, 130(5) 637-647, Nov, 2001
Porcine kidney D-amino acid oxidase: The three-dimensional structure and its catalytic mechanism based on the enzyme-substrate complex model（共著）

MIURA R, SETOYAMA C, NISHINA Y, SHIGA K, MIYAHARA I, MIZUTANI H, HIROTSU K

J. Mol. Catalysis B: Enzymatic, 12(1/6) 43-52, 2001
Substrate recognition and activation mechanism of D-amino acid oxidase: A study using substrate analogs

Y Nishina, K Sato, R Miura, K Shiga

JOURNAL OF BIOCHEMISTRY, 128(2) 213-223, Aug, 2000
Unusually high standard redox potential of acrylyl-CoA/propionyl-CoA couple among enoyl-CoA/acyl-CoA couples: A reason for the distinct metabolic pathway ay of propionyl-CoA from longer acyl-CoAs

K Sato, Y Nishina, C Setoyama, R Miura, K Shiga

JOURNAL OF BIOCHEMISTRY, 126(4) 668-675, Oct, 1999
Resonance Raman study on reduced flavin in purple intermediate of flavoenzyme: Use of [4-carbonyl-O-18]-enriched flavin

Y Nishina, K Sato, R Miura, K Matsui, K Shiga

JOURNAL OF BIOCHEMISTRY, 124(1) 200-208, Jul, 1998
A Raman study on the C(4)=O stretching mode of flavins in flavoenzymes: Hydrogen bonding at the C(4)=O moiety

Hazekawa, I, Y Nishina, K Sato, M Shichiri, R Miura, K Shiga

JOURNAL OF BIOCHEMISTRY, 121(6) 1147-1154, Jun, 1997
In vitro assembly of FAD, AMP, and the two subunits of electron-transferring flavoprotein: An important role of AMP related with the conformational change of the apoprotein

K Sato, Y Nishina, K Shiga

JOURNAL OF BIOCHEMISTRY, 121(3) 477-486, Mar, 1997
Electron Transfer Flavoproteinのヘテロダイマー型の二種の構造

佐藤恭介, 二科安三, 志賀潔

日本分子生物学会年会プログラム・講演要旨集, 19 235-235, Aug 1, 1996
In vitro refolding and unfolding of subunits of electron-transferring flavoprotein: Characterization of the folding intermediates and the effects of FAD and AMP on the folding reaction

K Sato, Y Nishina, K Shiga

JOURNAL OF BIOCHEMISTRY, 120(2) 276-285, Aug, 1996
SUBSTRATE ACTIVATING MECHANISM OF SHORT-CHAIN ACYL-COA, MEDIUM-CHAIN ACYL-COA, LONG-CHAIN ACYL-COA, AND ISOVALERYL-COA DEHYDROGENASES FROM BOVINE LIVER - A RESONANCE RAMAN-STUDY ON THE 3-KETOACYL-COA COMPLEXES

HAZEKAWA, I, Y NISHINA, K SATO, M SHICHIRI, K SHIGA

JOURNAL OF BIOCHEMISTRY, 118(5) 900-910, Nov, 1995
STRUCTURES OF CHARGE-TRANSFER COMPLEXES OF FLAVOENZYME D-AMINO-ACID OXIDASE - A STUDY BY RESONANCE RAMAN-SPECTROSCOPY AND EXTENDED HUCKEL MOLECULAR-ORBITAL METHOD

Y NISHINA, K SATO, R MIURA, K SHIGA

JOURNAL OF BIOCHEMISTRY, 118(3) 614-620, Sep, 1995

Books and Other Publications

Resonance Raman study on charge-transfer complexes of porcine D-amino acid oxidase (in D-Amino acids: A new frontier in amino acid and protein research-practical methods and protocols (Konno, R. et al. eds.) )

Nova Biomedical Books, New York, 2007

Presentations

静電ポテンシャルフィッティングにもとづく水モデルの設計

Dec 9, 2019
TIP5Pの負電荷の適切な位置

佐藤恭介

第32回分子シミュレーション討論会, Nov 28, 2018
Umbrella sampling on proton shift in catalytic base of enzyme

SATO Kyosuke

The 56th Annual Meeting of the BSJ, Sep 15, 2018

Professional Memberships

Mar, 2019 - Present

理論化学会
Jan, 2019 - Present

分子シミュレーション学会
May, 2015 - Present

THE BIOPHYSICAL SOCIETY OF JAPAN
May, 1998 - Present

日本生化学会
Apr, 1998 - Dec, 2015

日本生理学会

Works

Substrate-coenzyme alignment in flavoproteins

SATO Kyosuke

2012
電子伝達フラビン蛋白に含まれるAMPの役割

1995 - 1996
電子伝達フラビン蛋白のフォ-ルディングの機構

1994 - 1995
電子伝達フラビン蛋白における分子集合体形成と機能発現の関連

1993 - 1994
フラビンを中心とした電子伝達機構に与える蛋白の重合反応の影響について

1991 - 1994
ミトコンドリアの脂肪酸β酸化系における反応機構の分子論的研究

1989 - 1992
フラビン蛋白による電子移動およびエネルギ-産生機構の研究

1988 - 1989

Research Projects

Quantum chemical study on the mechanism of enzymatic reaction

The Other Research Programs, 2005
電子伝達フラビン蛋白に含まれるAMPの役割

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1995 - 1995

佐藤恭介
電子伝達フラビン蛋白のフォールディングの機構

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1994 - 1994

佐藤恭介
電子伝達フラビン蛋白における分子集合体形成と機能発現の関連

科学研究費助成事業, 奨励研究(A), 日本学術振興会, 1993 - 1993

佐藤恭介
THE EFFECT OF PROTEIN POLIMERIZATION ON THE ELECTRON TRANSFER MECHANISM OF FLAVOPROTEIN

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (B), Japan Society for the Promotion of Science, 1991 - 1993

SHIGA Kiyoshi, SATO Kyosuke, NISHINA Yasuzou
The molecular mechanism of electron transfer in mitochondria beta-oxidation

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (C), Japan Society for the Promotion of Science, 1989 - 1991

NISHINA Yasuzo, SATO Kyosuke, SHIGA Kiyoshi
フラビン蛋白による電子移動およびエネルギー産生機構の研究

科学研究費助成事業, 重点領域研究, 日本学術振興会, 1988 - 1988

志賀潔, 三浦洌, 佐藤恭介, 脇田良彬, 二科安三
A physico-chemical study on the interaction between amino acid oxidase and ligands

Grants-in-Aid for Scientific Research, Grant-in-Aid for General Scientific Research (A), Japan Society for the Promotion of Science, 1985 - 1988

SHIGA Kiyoshi, TOUZYOU Hiromasa, WAKITA Yoshiakira, NISHINA Yasuzo

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