2005年6月
Inhibitory activity on matrix metalloproteinases and cell-proliferating activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) - contrastive difference between human and bovine TIMP-1s on mouse cell proliferation
GROWTH FACTORS
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- 巻
- 23
- 号
- 2
- 開始ページ
- 135
- 終了ページ
- 142
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1080/08977190500138772
- 出版者・発行元
- TAYLOR & FRANCIS LTD
Either human or bovine TIMP-1 inhibited matrix metalloproteinase (MMP) activities, such as collagenolytic, gelatinolytic and caseinolytic, expressed by mouse cells as well as those expressed by human cells. Bovine TIMP-1 stimulated the proliferation of both human and mouse cells, but human TIMP-1 only proliferate human cells and not mouse cells indicating that the cell-proliferating activity has more strict species specificity than MMP inhibitory activity. All the results from [H-3]thymidine incorporation, the phosphorylation of tyro sine-containing cellular proteins and extracellular-signal-regulated protein kinases supported the cell-proliferating properties of both human and bovine TIMP-1s. Human TIMP-1 seems not to bind to TIMP-1 receptors on mouse cells.
- リンク情報
- ID情報
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- DOI : 10.1080/08977190500138772
- ISSN : 0897-7194
- Web of Science ID : WOS:000231132200007