Wakamatsu Kazumasa

Profile Information

Affiliation: School of Health Sciences Faculty of Medical Technology, Fujita Health University

Degree: 理学博士(名古屋大学)
博士（医学）(藤田保健衛生大学)

Researcher number: 80131259
J-GLOBAL ID: 200901043833632395
researchmap Member ID: 1000102734

Research Interests

melanin

Research Areas

Other / Other / melanin

Committee Memberships

Nov, 2019 - Nov, 2022

特別顧問, 日本色素細胞学会
Sep, 2015 - Nov, 2019

理事, 国際色素細胞学会連合
Nov, 2000 - Nov, 2019

理事, 日本色素細胞学会
Nov, 2015 - Oct, 2018

会長, 日本色素細胞学会
Nov, 2013 - Nov, 2015

事務局長, 日本色素細胞学会

Awards

Nov, 2020

清寺眞記念賞, リディアオリリー記念ピアス皮膚科学振興財団

若松一雅
Nov, 2018

The Cosmetology Research Foundation

Wakamatsu Kazumasa
Aug, 2017

Takeuchi Medal, International Federation of Pigment Cell Society

Wakamatsu Kazumasa

Major Papers

465

Recent Advances in Characterization of Melanin Pigments in Biological Samples

Kazumasa Wakamatsu, Shosuke Ito

International Journal of Molecular Sciences, 24(9), May 5, 2023

Misc.

Serum 5-s-cysteinyldopa for identifying non-responders to nivolumab treatment of melanoma.

Toshikazu Omodaka, Akane Minagawa, Hisashi Uhara, Kazumasa Wakamatsu, Tomonobu Koizumi, Hiroshi Koga, Ryuhei Okuyama

JOURNAL OF CLINICAL ONCOLOGY, 35, May, 2017
Characterization of melanin content and UV responses in human skin

Ciara Haddadeen, Samantha Robinson, Kazumasa Wakamatsu, Sandra Dixon, Carol Gough, Shosuke Ito, Brian Diffey, Peter Friedmann, Eugene Healy

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 72(5) AB29-AB29, May, 2015
Reptiles Produce Pheomelanin: Evidence in the Eastern Hermann's Tortoise (Eurotestudo boettgeri) (vol 47, pg 258, 2013)

Alexandre Roulin, Alia Mafli, Kazumasa Wakamatsu

JOURNAL OF HERPETOLOGY, 47(4) 619-620, Dec, 2013
An extract of Melia toosendan attenuates endothelin-1-stimulated pigmentation in human epidermal equivalents through the interruption of PKC activity within melanocytes (vol 303, pg 263, 2011)

Hiroaki Nakajima, Yuki Wakabayashi, Kazumasa Wakamatsu, Genji Imokawa

ARCHIVES OF DERMATOLOGICAL RESEARCH, 305(5) 463-465, Jul, 2013
Withania somnifera extract attenuates stem cell factor-stimulated pigmentation in human epidermal equivalents through interruption of ERK phosphorylation within melanocytes (vol 66, pg 435, 2012)

Hiroaki Nakajima, Katsunori Fukazawa, Yuki Wakabayashi, Kazumasa Wakamatsu, Genji Imokawa

JOURNAL OF NATURAL MEDICINES, 67(2) 424-424, Apr, 2013
機能性磁性ナノ粒子を用いた温熱療法で誘導される腫瘍浸潤T細胞におけるT細胞受容体のレパトワ解析

井藤彰, 山口雅紀, 岡本憲明, 實松裕次, 河邉佳典, 若松一雅, 伊藤祥輔, 本多裕之, 小林猛, 中山叡一 …

日本生物工学会大会講演要旨集, 64th 185-185, Sep 25, 2012
Chemical approaches to study melanin in fossil systems

Keely Glass, Shosuke Ito, Philip R. Wilby, Takayuki Sota, Atsushi Nakamura, C. Russell Bowers, Jakob Vinther, Suryendu Dutta, Roger Summons, Derek E. G. Briggs …

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 244, Aug, 2012
Oculocutaneous albinism 1 minimal pigment type; a case report on the analysis of genotype-phenotype correlation

M. Kono, T. Kondo, S. Ito, T. Suzuki, K. Wakamatsu, S. Ito, Y. Tomita

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 827-827, Aug, 2011
Human hair pigmentation characteristics revealed by melanin determination in human eumelanic hairs of various ethnic origins

S. Commo, K. Wakamatsu, B. A. Bernard, S. Ito

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 783-784, Aug, 2011
Development and evaluation of antitumor effect of novel NPrCAP-magnetite nanoparticles for chemo-thermo-immunotherapy in malignant melanoma

A. Yoneta, Y. Tamura, S. Nohara, A. Ito, H. Honda, K. Wakamatsu, S. Ito, T. Yamashita, K. Jimbow

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 854-855, Aug, 2011
Serum 5-S-cysteinyldopa levels in psoriasis and vitiligo patients undergoing narrowband ultraviolet B phototherapy

K. Kikuchi, K. Wakamatsu, Y. Tada, S. Ito

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 836-836, Aug, 2011
A novel pathway for regulation of pigmentation by glutamate receptor mGluR6 through its action on TRPM1

S. Devi, Y. Markandeya, N. Maddodi, K. Wakamatsu, S. Ito, R. Balijepalli, V. Setaluri

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 785-786, Aug, 2011
N-Propionyl-4-S-Cysteaminylphenol generates reactive oxygen species and mediates apoptosis in pigmented melanoma cells

Y. Ishii-Osai, T. Yamashita, M. Okura, Y. Tamura, N. Sato, A. Ito, H. Honda, K. Wakamatsu, S. Ito, K. Jimbow

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 855-855, Aug, 2011
Evaluation of alkaline hydrogen peroxide oxidation to analyze eumelanin and pheomelanin

S. Ito, Y. Nakanishi, K. Wakamatsu

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 783-783, Aug, 2011
Chemistry and biophysics of melanins

K. Wakamatsu, T. Murase, F. A. Zucca, L. Zecca, S. Ito

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 764-764, Aug, 2011
Slaty mutation inverses the ratio of DHI to DHICA content of eumelanin in both mouse melanocytes and hair

Y. Niki, T. Hirobe, K. Wakamatsu, H. Ando, M. Yoshida, M. Ichihashi, S. Ito

PIGMENT CELL & MELANOMA RESEARCH, 24(4) 817-817, Aug, 2011
Astaxanthin attenuates the stem cell factor-stimulated pigmentation of human epidermal equivalents through interruption of Raf-1 activity within melanocytes

Genji Imokawa, Katsunori Fukazawa, Hiroaki Nakjima, Kazumasa Wakamatsu, Yashuhiro Senda

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130 S94-S94, Sep, 2010
The Phenolic Compound, N-Propionyl-Cysteaminylphenol is Selectively Incorporated into B16F1 Melanoma Cells and Induces Apoptotic Cell death.

Yasue Osai, Yasuaki Tamura, Noriyuki Sato, Kazumasa Wakamatsu, Shosuke Ito, Akira Ito, Hiroyuki Honda, Masae Okura, Toshiharu Yamashita, Kowichi Jimbow

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130 S97-S97, Sep, 2010
Glucosamine, an asparagine-linked carbohydrate core synthesis inhibitor, attenuates endothelin-1+stem cell factor-stimulated pigmentation in human epidermal equivalents by interrupting the endothelin-1-triggered intracellular signaling pathway within melanocytes.

Yuki Wakabayashi, Shouhei Oka, Hiroaki Nakajima, Kazumasa Wakamatsu, Genji Imokawa

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130 S97-S97, Sep, 2010
N-Propionyl-Cysteaminylphenol Suppresses Re-Challenge of Mouse B16F1 Tumor by Inducing Tumor-Specific Immune Response

Y. Osai, Y. Tamura, N. Sato, K. Wakamatsu, H. Honda, M. Okura, T. Yamashita, K. Jimbow

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129 S42-S42, Sep, 2009

Books and Other Publications

Visual Dermatology-知りたい！美容皮膚科のいま Part 2

(Role: Contributor)

Aug, 2018
色素細胞-基礎から臨床へ-

伊藤祥輔, 柴原茂樹, 錦織千佳子 (Role: Contributor, メラニンの構造とその機能)

慶應義塾大学出版会, 2015
メラニンの化学 – 化学的微量分析法の開発とその応用例. 知りたい美容皮膚科のいま.

(Role: Contributor)

Visual Dermatology., 2013
Visual Dermatology - 知りたい！美容皮膚科のいま

若松一雅 (Role: Contributor, メラニンの化学-微量化学的分析法の開発とその応用例)

秀潤社, 2013
Melanins and Melanosomes: Biosynthesis, Biogenesis, Physiological, and Pathological Functions.

Ito, S, Wakamatsu, K, d’Ischia, M, Napolitano, A, Pezzella, A (Role: Contributor, Structure of Melanins:)

Wiley-Blackwell, 2011
Melanins and Melanosomes - Biosnthesis, Biogenesis, Physiological, and Pathological Functions

Borovansky J, Riley PA

Wiley-Blackwell, 2011
Regulation of melanocyte fate by agouti signal protein.

Le Pape E, Wakamatsu K, Glubellino A, Valencia JC, Passeron T, Ito S, Wolber R, Hearing VJ (Role: Contributor)

IPCC Publications, 2008
メラニン色素の化学. 水産物の色素. 嗜好性と機能性.

(Role: Contributor)

2008
Coastal Oceanography and Sustainable Marine Aquaculture, Confluence & Synergy

Adachi k, Kato K, Wakamatsu K, Ito S, Ishimaru K, Hirata T, Murata O, Kumai H (Role: Contributor, Melanogenesis in fish and prawn.)

Proceedings of the International Conference, 2006
The Pigmentary System.

Ito, S, Wakamatsu, K (Role: Contributor, Chemistry of Melanins)

Blackwell Publishing, 2006
The Pigmentary System: Physiology and Pathophysiology, Second Edition

Nordlund JJ, Boissy RE, Hearing VJ, King RA, Oetting WS, Ortonne JP

Blackwell Publishing, 2006
Mechanism of Suntanning

Tadokoro, T, Kobayashi, N, Beer, J. Z, Zmudzka, B. Z, Wakamatsu, K, Miller, S. A, Lamoreux, M. L, Ito, S, Hearing, V. J (Role: Contributor, The biochemistry of melanogenesis and its regulation by ultraviolet radiation.)

Martin Dunitz Publ, 2002
Catecholamine Research from Molecular Insights to Clinical Medicine

Nagatsu T, Nabeshima T, McCarty R, Goldstein DS (Role: Contributor, Structure and Function of Neuromelanin.)

Kluwer Academic/Plenum Publishers, 2002
色素細胞-機能と発生分化の分子機構から色素性疾患への対応を探る

若松一雅, 伊藤祥輔 (Role: Contributor)

慶應義塾大学出版会, 2002
Frontiers in Neutron Capture Therapy

Yoshino, Y, Kamijo, M, Kimura, M, Mishima, Y, Kondoh, H, Kadota, M, Ito, S, Wakamatsu, K, Kakihana, H (Role: Contributor, A further mechanism study of boron accumulation to and release from melanoma with p-boronophenylalanine.)

Plenum Press Proc., 2001
血中腫瘍マーカーとしての5-S-CD.悪性黒色腫の診断・治療指針

若松一雅 (Role: Contributor)

金原出版, 2001
Melanogenesis and Malignant Melanoma: Biochemistry, Cell Biology, Molecular Biology, Pathophysiology, Diagnosis, and Treatment.

Horikoshi T, Ito S, Wakamatsu K, Onodera H, Hanada N, Hamaoka S, Eguchi H (Role: Contributor, Serum 5-S-cysteinyldopa in patients with metastatic melanoma.)

Elsevier Science, 1996
Melanogenensis and malignant melanoma: cell biology, molecular biology, pathophysiology, diagnosis and treatment.

Ito, S, Ozeki, H, Wakamatsu, K (Role: Contributor, Spectrophotometric and HPLC characterization of hair melanins.)

Elsevier Science, 1996
Melanogenesis and Malignat Melanoma: Biochemistry, Cell Biology, Molecular Biology, Pathophysiology, Diagnosis, and Treatment

Hori Y, Hearing VJ, Nakayama

Elsevier, Amsterdam, 1996
Colour Sheep and Coloured Fibres of Animal Origin

Summer RMW, Ito S, Wakamatsu K (Role: Contributor, Using objective measurements to understand the biology of wool colour.)

Rare Breeds Survival Trust, 1994

Presentations

Melanin analysis for hair samples from Japanese patients with Hermansky-Pudlak sundrome type 1, 4, 6, and 9.

Okamura, K, Araki, Y, Abe, Y, Wakamatsu, K, Tamiya, G, Seishima, M, Umetsu, T, Kato, A, Kawaguchi, M, Hayashi, M, Hozomi, Y, Suzuki, T

23rd International Pigment Cell Conference., Aug 27, 2017
Pro-oxidant activity of mouse hair pheomelanin is promoted by UVA irradiation.

Tanaka, H, Yamashita, Y, Ito, S, Wakamatsu, K

23rd International Pigment Cell Conference., Aug 27, 2017
Structural modification in oxidative coupling reaction of dopamine to cysteine-containing peptidic moieties.

Nakao, K, Kumura, Y, Ojika, M, Ito, S, Wakamatsu, K

23rd International Pigment Cell Conference., Aug 27, 2017
Roles of pH in mixed melanogenesis.

Wakamatsu, K

23rd International Pigment Cell Conference, Aug 27, 2017
カテコールアミン代謝物のオルトキノン体の反応性の比較

若松一雅, 山中佑太, 田中ひとみ, 小鹿一, 伊藤祥輔

第27回日本色素細胞学会学術大会, Nov 12, 2016
N-acetylcysteine(NAC)は紫外線によるロドデノールの色素細胞障害性増強効果を軽減する.

後藤典子, 辻本昌理子, 永井宏, 正木太朗, 伊藤祥輔, 若松一雅, 錦織千佳子

第27回日本色素細胞学会学術大会, Nov 12, 2016
ロドデノールユーメラニンは強い酸化促進作用をもつ.

伊藤祥輔, 黄倉真恵, 若松一雅, 山下利春

第27回日本色素細胞学会学術大会, Nov 12, 2016
The metabolic fate of ortho-quinones derived from catechol metabolites.

Wakamatsu, K, Yamanaka, Y, Ojika, M, Ito, S

20th European Society of Pigment Cell Research Meeting, Sep 11, 2016 Invited
マウスの毛髪突然変異遺伝子、スレｰティーはメラノサイトにおける黄色メラニン生成には影響しない

広部知久, 伊藤祥輔, 若松一雅

第26回日本色素細胞学会, Nov 15, 2015
メラニン産生細胞におけるロドデノールの代謝

伊藤祥輔, 黄倉真恵, 山下利春, 小鹿一, 中西由紀子, Wolfram Gerwat, Ludger Kolbe, 若松一雅

第26回日本色素細胞学会, Nov 14, 2015
The elucidation of structure of neuromelanin (NM): 1) a new method to synthesize o-aminophenol derivatives as putative degradative markers for pheomelanic structure of NM. 2) a chemical evidence indicating that locus coeruleus (LC)-NM contains norepinephr

Wakamatsu Kazumasa

XXII International Pigment Cell Conference, Sep, 2014
Tyrosinase-catalyzed oxidation of rhododendron produces 2-methylchromane-6,7-dione, the ultimate toxic metabolite: implications for melanocyte toxicity

Wakamatsu Kazumasa

XXII International Pigment Cell Conference, Sep, 2014
Regulation of murine pigment production by endothelia 3

Wakamatsu Kazumasa

XXII International Pigment Cell Conference, Sep, 2014
Production of reactive oxygen species and anti-oxidative responses in rhododendron-treated human melanocytes

Toshiharu Yamashita, Masae Okura, Yasue Ishii-Osai, Momoko Yoshikawa, Yasuyuki, Sumikawa, Kazumasa Wakamatsu, Shosuke Ito

XXII International Pigment Cell Conference, Sep, 2014
Weakly acidic pH suppresses eumelanogenesis but promotes pheomelanogenesis

Kazumasa Ito, Shosuke Ito, Kazumasa Wakamatsu

XXII International Pigment Cell Conference, Sep, 2014
Detection of circulating melanoma cells in melanoma patients

Takimasa Hida, Kazumasa Wakamatsu, Toshiharu Yamashita

XXII International Pigment Cell Conference, Sep, 2014
Evaluation of approach to structure of neuromelanin present in various brain regions as studied by chemical degradative methods

Kazumasa Wakamatsu

Sep, 2014 Invited
量子化学計算からの5,6-dihydroxyindoleの光吸収特性の重合度と酸化度への依存性

増田吉弘, 奥田英和, 小池謙造, 門田圭司, 中村隆仁, 若松一雅, 伊藤祥輔, 宗田孝之

第25回日本色素細胞学会, Nov, 2013
チロシナーゼのS-パルミトイル化はその分解を制御しメラニン生成を調整する

仁木洋子, 深田正紀, 深田優子, 奥慎一郎, 岡村千絵子, 竹内聖二, 若松一雅, 伊藤祥輔, 錦織千佳子, Lieve Declercq、Daniel, B. Yarosh, 齋藤尚亮

第25回日本色素細胞学会, Nov, 2013
中性pHと銅イオンはドーパクロム以降のユーメラニン形成を促進する

伊藤祥輔, 鈴木菜摘, 竹林史織, Stéphane Commo, 若松一雅

第25回日本色素細胞学会, Nov, 2013

Professional Memberships

Research Projects

Effects of ALDH2 Polymorphism and Alcohol Consumption on Melanoma Onset-Experimental Approach

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2025
Development of non-invasive diagnostic method for nail melanoma by measuring melanin-related substances in the nail plates

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
ヒト脳内の青斑核に存在するニューロメラニン様色素の構造解析とその加齢過程の解析

基盤研究(C), 日本学術振興会科研費, Apr, 2015 - Mar, 2018

若松一雅
ユーメラニンおよびフェオメラニンの紫外線による分解過程の解明とその生理的意義

基盤研究(C), 日本学術振興会科研費, Apr, 2014 - Mar, 2017

伊藤祥輔
炎症を背景としたマウス大腸発がんモデルに対するキダチアロエ低分子成分の修飾作用

基盤研究(C), 日本学術振興会科研費, Apr, 2013 - Mar, 2016

新保寛
ヒト脳内に存在するメラニン様色素の構造とその加齢過程の解明

基盤研究(C), 日本学術振興会科研費, Apr, 2012 - Mar, 2015

若松一雅
ユーメラニンおよびフェオメラニンの紫外線による生理的分解過程の解明

基盤研究(C), 日本学術振興会科研費, Apr, 2011 - Mar, 2014

伊藤祥輔
マウス大腸炎および発がんモデルに対する低用量アロエエモジンの修飾作用

基盤研究(C), 日本学術振興会科研費, Apr, 2010 - Mar, 2013

新保寛
ヒト脳内に存在するニューロメラニン色素の構造とその生成過程の解明

基盤研究(C), 日本学術振興会科研費, Apr, 2009 - Mar, 2012

若松一雅
メラノジェネシス標的NPrCAP・ナノ微粒子による次世代型メラノーマ化学温熱免疫(CTI)治療法の開発

厚生労働省研究事業, Apr, 2009 - Mar, 2012

神保孝一
メラニン生成関連遺伝子及び紫外線によるメラニン生成の制御機構

基盤研究(C), 日本学術振興会科研費, Apr, 2008 - Mar, 2011

伊藤祥輔
不活性ガスによる甲殻類黒変酵素の選択的不活性化機構の解明と黒変防止技術の開発

基盤研究(A), 日本学術振興会科研費, Apr, 2007 - Mar, 2011

平田孝
ヒト中脳黒質に存在するニューロメラニンの構造とその生成過程の解明

基盤研究(C), 日本学術振興会科研費, Apr, 2007 - Mar, 2009

若松一雅
マウス及びヒトにおける色素遺伝子と紫外線によるメラニン生成の制御機構

基盤研究(C), 日本学術振興会科研費, Apr, 2006 - Mar, 2008

伊藤祥輔
メラノーマ標的ナノ微粒子(NPrCAP/ML)によるメラノーマ温熱免疫療法の開発

厚生労働省研究事業, Apr, 2005 - Mar, 2008

神保孝一
甲殻類のメラニン生成に関わる新経路の解明とその阻害による黒変防止

基盤研究(B), 日本学術振興会科研費, Apr, 2004 - Mar, 2007

平田孝
色素遺伝子及び紫外線によるメラニン生成の制御機構

基盤研究(C), 日本学術振興会科研費, Apr, 2004 - Mar, 2006

伊藤祥輔
関連遺伝子及び紫外線によるメラニン生成の調節機構の解析

基盤研究(C), 日本学術振興会科研費, Apr, 2002 - Mar, 2004

伊藤祥輔
メラニン生成能を利用したメラノーマ特異的化学療法剤の開発

基盤研究(C), 日本学術振興会科研費, Apr, 2001 - Mar, 2003

井上茂樹
哺乳類のメラニン生成の遺伝的および非遺伝的調節機構

基盤研究(C), 日本学術振興会科研費, Apr, 2000 - Mar, 2002

伊藤祥輔

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Research Interests

Research Areas

Committee Memberships

Awards

Major Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Research Projects

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