SHIMPO(SHINPO) Hiroshi(Kan)

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Name
SHIMPO(SHINPO) Hiroshi(Kan)
Affiliation
Fujita Health University
Degree
Ph.D., D.M.S.(Doctor of Philosophy, Doctor of Medical Science)(Fujita Health University)
Research funding number
10142580

Research Interests

 
 

Research Areas

 
 

Academic & Professional Experience

 
 
   
 
Professor of Division of Biochemistry, Fujita Health University Fujita Memorial Nanakuri Institute, Fujita Memorial Nanakuri Institute
 
1975
 - 
1978
Research Associate, Institute for
 
 
   
 
Comprehensive Medical Science, Fujita Health
 
 
   
 
University
 
1978
 - 
1985
Instructor, Institute for Comprehensive
 

Education

 
 
 - 
1975
Faculty of Medical Technology, Faculty of Hygienic Science, Fujita-Gakuen University
 

Committee Memberships

 
2004
   
 
Japanese Society for Medical Use of Functional Foods  councillor
 

Published Papers

 
Mizutani K, Sonoda S, Wakita H, Shimpo K.
American Journal of Physical Medicine & Rehabilitation   94(3) 239-243   Mar 2015   [Refereed]
Dietary administration of Aloe vera gel extract inhibits intestinal polyp formation in Min mice fed a high-fat diet.
Chihara T, Shimpo K, Beppu H, Kaneko T, Higashiguchi T, Sonoda S, Tanaka M, Yamada M, Abe F
Pharmaceutica Analytica Acta   6(3) 1000340   2015   [Refereed]
Chihara T, Shimpo K, Kaneko T, Beppu H, Higashiguchi T, Sonoda S, Tanaka M, Yamada M, Abe F
Asian Pacific Journal of Cancer Prevention   16(2) 683-687   2015   [Refereed]
Kaneko T, Chihara T, Shimpo K, Beppu H, Higashiguchi T, Sonoda S.
Asian pacific Journal of Cancer Prevention   16(9) 3881-3885   2015   [Refereed]
Chihara T, Shimpo K, Beppu H, Yamamoto N, Kaneko T, Wakamatsu K, Sonoda S.
16(9) 3887-3891   2015   [Refereed]
Mizutani K, Sonoda S, Wakita H, Katoh Y, Shimpo K.
Neurological Sciences   35(1) 53-59   2014   [Refereed]
Shimpo K, Chihara T, Kaneko T, Beppu H, Wakamatsu K, Shinzato M, Yukitake J, Sonoda S.
Asian Pacific Journal of Cancer Prevention.   15(10) 5587-5592   2014   [Refereed]
Experimental Research on Stimulation of Wound Healing by n-3 Fatty Acids.
Futamura A, Higashiguchi T, Ito A, Kodama Y, Chihara T, Kaneko T, Tomatsu A, Shimpo K.
Wounds   25(7) 186-192   Jul 2013   [Refereed]
Mizutani K, Sonoda S, Karasawa N, Yamada K, Shimpo K, Chihara T, Takeuchi T, Hasegawa Y, Kubo K.
Neurol. Sci.   34(6) 861-867   2013   [Refereed]
The effect of preparatory conditions of high temperature- and pressure-treated garlic on 5-hydroxymethyl-2-furfural and S-allylcysteine formation.
Chihara T, Shimpo K, Kaneko T, Tomatsu A, Beppu H, Higashiguchi T, Sonoda S.
Journal of Analytical Bio-Science.   36 186-192   2013   [Refereed]
Takeshi Chihara, Kan Shimpo, Hidehiko Beppu, Akiko Tomatsu, Takaaki Kaneko, Miyuki Tanaka, Muneo Yamada, Fumiaki Abe, and Shigeru Sonoda.
Asian Pacific Journal of Cancer Prevention.   14(7) 4435-4440   2013   [Refereed]
The effect of preparatory conditions of high temperature- and pressure-treated garlic on 5-hydroxymethyl-2-furfural and S-allylcysteine formation
Chihara T, Shimpo K, Kaneko T, Tomatsu A, Beppu H, Higashiguchi T, Sonoda S.
Journal of Analytical Bio-Science   36 186-192   2013   [Refereed]
Kaneko T, Shimpo K, Chihara T, Beppu H, Tomatsu A, Shinzato M, Yanagida T, Ieike T, Sonoda S, Futamura A, Ito A, Higashiguchi T.
Asian Pac. J. Cancer Prev.   13 1983-1988   2012   [Refereed]
Takahashi H, Kosino E, Mikuni K. Kiuchi Y, Beppu H, Okazaki H, Shimpo K, Sonoda S .
Journal of Glycoscience.   59(3) 97-103   2012   [Refereed]
Takahashi H, Kosino E, Mikuni K. Kiuchi Y, Beppu H, Okazaki H, Shimpo K, Sonoda S .
Journal of Glycoscience   59(3) 97-103   2012   [Refereed]
Mizutani K, Sonoda S, Yamada K, Beppu H, Shimpo K
Brain Research   1416 61-68   2011   [Refereed]
Takahashi H, Bungo Y, Mikuni K, Beppu H, Ozaki S, Shimpo K, Itani Y, Sonoda S
Journal of Applied Glycoscience   57 193-197   2010   [Refereed]
Evaluation of the Effects of the ingestion of Ajoene, a sulfur containing compound derived from oil-macerated garlic, on metabolic parameters, abdominal circumference, and blood pressure in Japanese metabolic syndrome patients. A pilot study.
Beppu H, Matsumoto Y, Fujino T, Itani Y, Sumitho T, Higashiguchi T, Chihara T, Tamai I, Sonoda S, Shimpo K
J. Anal. Bio-Sci.   33(5) 441-450   2010
Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T
Biochim. Biophys. Acta.   1800(7) 669-673   2010
Takahashi H, Bungo Y, Mikuni K, Beppu H, Ozaki S, Shimpo K, Itani Y, Sonoda S (2010).
J. Appl. Glycosci.   57 193-197   2010
Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A
Mol Carcinog.   49(7) 662-71   2010
Mizutani K, Sonoda S, Hayashi N, Takasaki A, Beppu H, Saitoh E, Shimpo K
Am. J. Phys. Med. Rehabil.   89(2) 107-114   2010
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and o6-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.
Chihara T, Shimpo K, Kaneko T, Beppu H, Mizutani K, Higashiguchi T, Sonoda S.
Asian Pacific Journal of Cancer Prevention   11(5) 1301-1305   2010
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and o6-methylguanine DNA adducts in the rat colorectum by boiled garlic powder.
Chihara T, Shimpo K, Kaneko T, Beppu H, Mizutani K, Higashiguchi T, Sonoda S.
Asian Pac J Cancer Prev.   11(5) 1301-1304   2010   [Refereed]
Inhibition of 1, 2-dimethylhydrazine-induced mucin-depleted foci and o6-methylguanine DNA adducts in the rat colorectum by boiled garlic powder
Chihara T, Shimpo K, Kaneko T, Beppu H, Mizutani K, Higashiguchi T, Sonoda S.
Asian Pacific Journal of Cancer Prevention.   11(5) 1301-1304   2010   [Refereed]
Mizutani K, Sonoda S, Hayashi N, Takasaki A, Beppu H, Saitoh E, Shimpo K
American Journal of Physical Medicine & Rehabilitation   89(2) 107-114   2010   [Refereed]
Hosono K, Endo H, Takahashi H, Sugiyama M, Uchiyama T, Suzuki K, Nozaki Y, Yoneda K, Fujita K, Yoneda M, Inamori M, Tomatsu A, Chihara T, Shimpo K, Nakagama H, Nakajima A
Molecular Carcinogenesis   49(7) 662-671   2010   [Refereed]
Endo M, Beppu H, Akiyama H, Wakamatsu K, Ito S, Kawamoto Y, Shimpo K, Sumiya T, Koike T, Matsui T
Biochimica et Biophysica Acta   1800(7) 669-673   2010   [Refereed]
Evaluation of the effects of the ingestion of ajoene, a sulfur containing compound derived from oil-macerated garlic, on metabolic parameters, abdominal circumference, and blood pressure in Japanese metabolic syndrome patients
Beppu H, Matsumoto Y, Fujino T, Itani Y, Sumitho T, Higashiguchi T, Chihara T, Tamai I, Sonoda S, Shimpo K
Journal of Analytical Bio-Science   33(5) 441-450   2010   [Refereed]
Inhibitory effects of high temperature-and pressure-treated garlic on formation of 1,2-dimethylhydrazine-induced mucin-depleted foci and O6-methylguanine DNA adducts in the rat colorectum
Chihara T., Shimpo K., Kaneko T., Beppu H., Tomatsu A., Sonoda S
Asian Pacific Journal of Cancer Prevention.   10 827-831   2009   [Refereed]
Erythrocyte spermidine as a biomarker for focal cerebral infarction in rat.
Mizutani K, Shimpo K, Chihara T and Sonoda S
Biogenic Amines   21(3) 169-176   2007
Improvement of thermal stability and absorption in humans of Coenzyme Q10 with cyclodextrin.
Takahashi H, Bungo Y, Mikuni K, Beppu H, Ozaki S, Shimpo K, Itani Y, Sonoda S
Proceedings of Fourth Asian Cyclodextrin Conference (ACC 2007)   124-128   2007
Improvement of thermal stability and absorption in humans of Coenzyme Q10 with cyclodextrin
Takahashi H, Bungo Y, Mikuni K, Beppu H, Ozaki S, Shimpo K, Itani Y, Sonoda S
Proceedings of Fourth Asian Cyclodextrin Conference (ACC 2007)   124-128   2007   [Refereed]
Effects of Aloe arborescens ingestion on azoxymethane-induced intestinal carcinogenesis and on hematological and biochemical parameters of male F344 rats.
Shimpo K, Beppu H, Chihara T, Kaneko T, Shinzato M, Sonoda S
Asian Pacific Journal of Cancer Prevention   7(4) 585-590   2006
Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S, Kuzuya H
Phytomedicine   13(1-2) 49-60   2006   [Refereed]
Clinical effects of FP-10 against H. pylori infection
Inoue T, Suzuki K, Beppu H, Kawai K, Shimpo K, Sonoda S, Nakano H
Journal of Analytical Bio-Science   28(5) 428-432   2005   [Refereed]
Studies on the components of Aloe arborescens from Japan-monthly variation and differences due to part and position of the leaf. "jointly worked"
Beppu H, Kawai K, Shimpo K, Chihara T, Tamai I, Ida C, Ueda M, Kuzuya H
Biochemical Systematics and Ecology   32 783-795   2004
Modulation of quinone reductase, alcohol dehydrogenase and cytochrome P450 2E1 activities in rat liver by Aloe arborescens var.natalensis (Kidachi Aloe).
Shimpo K, Ida C, Chihara T, Beppu H, Kaneko T, Kuzuya H
Natural Medicines   58(1) 27-30   2004
Shimpo K, Chihara T, Shinzato M, Beppu H, Kaneko T, Shamoto M, Kuzuya H.
Pharmaceutical Biology   41(8) 631-636   2003
Inhibition of azoxymethane-induced DNA adduct formation by Aloe arborescens var.natalensis.
Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Hoshino M, Kuzuya H.
Asian Pacific Journal of Cancer Prevention   4(3) 247-251   2003
Beppu H, Koike T, Shimpo K, Chihara T, Hoshino M, Ida C, Kuzuya H.
Journal of Ethnopharmacology   89 37-45   2003
Inhibitory of tyrosinase activity by isobarbaloin. "jointly worked"
Beppu H, Ueda M, Chihara T, Shimpo K, Ito S, Kuzuya H.
Journal of Creative Approach for Health   2(1) 57-60   2003
Inhibitory effects of heated garlic on N-ethy-N'-nitro-N-nitrosoguanidine-induced carcinogenesis in the duodenum and jejunum of C57BL/6 mice.
Shimpo K, Chihara T, Kaneko T, Shinzato M, Beppu H, Hoshino M, Ida C, Shamoto M, Kuzuya H.
Asian Pacific Journal of Cancer Prevention   3(4) 339-344   2002
Inhibiton of cytochrome P450 2E1 activity by freeze-dried whole-leaf Aloe arborescens(Kidachi aloe).
Shimpo K, Chihara T, Beppu H, Ida C, Hoshino M, Kuzuya H.
Journal of Creative Approach for Health   1(4) 253-258   2002
Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl) amine-induced pancreatic carcinogenesis in hamsters. "jointly worked"
Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, Lee I-S, Hirose M.
Cancer Letters   178 117-122   2002
Shimpo K, Ida C, Chihara T, Beppu H, Kaneko T, Kuzuya H.
Phytotherapy Research   16 491-493   2002
Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole-leaf Aloe arborescens Miller var. natalensis Berger.
Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Nagatsu T, Kuzuya H.
Phytotherapy Research   15 705-711   2001
Kuzuya, H, Tamai, I, Beppu, H, Shimpo, K, and Chihara, T
Journal of Chromatography B   752 91-97   2001
High-performance liquid chromatographic determination of the diacetylpolyamines using benzoyl chloride as a derivatizing agent : application to human urine
Shimpo, K, Chihara, T, Ida, C, Kawai, K, Wakamatsu, K, Ito, S, Matsui, T, Hirano, M, Watanabe, T, Nagatsu, T, and Kuzuya, H
Biogenic Amines   16(3) 211-223   2001
Inhibition of N-ethyl-N'-nitro-N-nifrosoguanidine-induced duodenal tumorigenesis in mice by whole-leaf Aloe arborescens Miller var. natalensis Berger "jointly worked"
Chihara T, Shimpo K, Shinzato M, Beppu H, Kaneko T, Ida C, Kawai K, Hirono I, Shamoto M, Nagatsu T.
Asian Pacific Journal of Cancer Prevention   1(4) 283-288   2000
In Vivo Effects of Aloe arborescens Miller var.natalensis Berger(Kidachi aloe)on Experimental Tinea Pedis in Guinea-pig Feet. "jointly worked"
Kawai K, Beppu H, Shimpo K, Chihara T, Yamamoto N, Nagatsu T, Ueda H, Yamada Y.
Phytotherapy Research   12 178-182   1998
Simultaneous measurements of monoamines,their metabolites and precursor amino acids in plasma and urine from healthy subjects by HPLC/multi-electrode electrochemistry. "jointly worked"
Kuzuya H, Fujita K, Sakamoto H, Kawai K, Shimpo K, Beppu H, Ishida M, Ito T.
Biogenic Amines   12(1) 9-18   1996
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by Hemicalcium asocorbate,2-0-octadecylascorbic acid and ascorbyl palmitate.
Shimpo K, Takahashi H, Tsuda H, Hibino T, Kawai K, Kimura C, Nagatsu T, Fujita K.
Cancer Detection and Prevention   20 137-145   1996
A 35 kDa mannose-binding lectin with hemagglutinating and mitogenic activities from "Kidachi Aloe"(Aloe arborescens Miller var.natalensis Berger) "jointly worked"
Koike T, Beppu H, Kuzuya H, Maruta K, Shimpo K, Suzuki M, Titani K, Fujita K.
J.Biochem.   118(6) 1205-1210   1995
Koike T, Titani K, Suzuki M, Beppu H, Kuzuya H, Maruta K, Shimpo K, Fujita K.
Biochem.Biophys.Res.Commun.   214(1) 163-170   1995
T Cell Receptor Beta Diversity and Joining Segments in the NOD Mouse "jointly worked"
Winter WE, Yamada K, Shimpo K, Luchetta R, Wakeland EK.
Autoimmunity   12,9-12    1992
Ascorbic acid and adriamycin toxicity
Shimpo K, Nagatsu T, Yamada K, Sato T, Niimi H, Shamoto M, Takeuchi T, Umezawa H, Fujita K.
American Journal of Clinical Nutrition   54 1298S-1301S   1991
Polyamine levels of urine and erythrocytes on inhibition of DMBA-induced oral carcinogenesis by topical beta-carotene "jointly worked"
Hibino T, Shimpo K, Kawai K, Chihara T, Maruta K, Arai M, Nagatsu T, Fujita K
Biogenic Amines   7(3) 209-216   1990
Immunogenetic Analysis of B-Cell Autoimmunity in NOD Mice "jointly worked"
Winter WE, Shimpo K, Obata M, Yamada K, Luchetta R.
Diabetes   39(8) 975-982   1990
Combined use of urinary pteridines measured by radioimmunoassays and polyamines as tumor markers. "jointly worked"
Fujita K, Shinpo K, Kimura E, Sugimoto T, Matsuura S, Yamaguchi T, Nagatsu T
Biogenic Amines   4(1) 33-43   1987
Kojima K, Mihara R, Sakai T, Togari A, Matsui T, Shinpo K, Fujita K, Fukasawa K, Harada M, Nagatsu T.
Biochemical Medicine and Metabolic Biology   37 34-41   1987
Comparative measurements of urinary polyamines in early morning and 24-hour urine specimens "jointly worked"
Shinpo K, Fujita K, Maruta K, Teradaira R, Nagatsu T.
Clinica Chimica Acta   131 143-148   1983
Reduction of Adriamycin Toxicity by Ascorbate in Mice and Guinea Pigs "jointly worked"
Fujita K, Shinpo K, Yamada K, Sato T, Niimi H, Shamoto M, Nagatsu T, Takeuchi T, Umezawa H.
Cancer Research   42 309-316   1982
Improved Analysis for Urinary Polyamines by Use of High-Voltage Electrophoresis on Paper "jointly worked"
Fujita K, Nagatsu T, Shinpo K, Maruta K, Teradaira R, Nakamura M.
Clinical Chemistry   26(11) 1577-1582   1980
Specific reaction of aloe extract with serum proteins of various animals. "jointly worked"
Fujita K, Suzuki I, Ochiai J, Shinpo K, Inoue S, Saito H.
Experientia   34 523-524   1978
Increase of Urinary Putrescine in 3,4-Benzopyrene Carcinogenesis and Its Inhibition by Putrescine "jointly worked"
Fujita K, Nagatsu T, Shinpo K, Maruta K, Takahashi H, Sekiya A.
Cancer Research   38 3509-3511   1978
Dopamine-β-hydroxylase activity in human cerebrospinal fluid and serum. "jointly worked"
Fujita K, Maruta K, Teradaira R, Beppu H, Shinpo K, Maeno Y, Ito T, Nagatsu T, Kato T.
J.Neurochem.   29 1141-1142   1977

Misc

 
Ancient herb in new form delivers proven effects. "jointly worked"
Fujita K, Beppu H, Kawai K, Shimpo K.
Aloe Today   Winter 9-13   1992

Books etc

 
Assay methods for polyamines(Chapter 12) "jointly worked" /METHODS IN BIOGENIC AMINE RESEARCH
ELSEVIER   1983   
Assay methods for polyamines(Chapter 7) "jointly worked" /Methods in neurotransmitter and neuropeptide research
Elsevier Science Publishers B. V.   1993   
Acetyloplyamines in urine and polyamines in erythrocytes as biochemical markers of cancer.Polyamines : Basic and Clinical Aspects. "jointly worked"
VNU Science Press   1985   
Occurrence and Biosynthesis of Protein-Bound Dopa and Cysteinyldopas. Structure and Function of Melanin "jointly worked"
Fuji shoin   1986   
Biopterin and Neopterin as Neurochemical Markers of Neurological Diseases. "jointly worked" /Progress in HPLC-HPCE Volume 7.
VSP BV   1998   

Research Grants & Projects

 
Pharmacological effect(especially cancer prevention) of Aloe
The Other Research Programs
Project Year: 1975   
Determination of polyamines and its evaluation for cancer markers
The Other Research Programs
Project Year: 1975