NAKADA HIROSHI

Profile Information

Degree: Doctor of Pharmaceutical Science(Kyoto University)
Master of Pharmaceutical Science(Kyoto University)
Doctor of Pharmaceutical Science(Kyoto University)

J-GLOBAL ID: 200901023539617093
researchmap Member ID: 1000104002

Research Interests

Research Areas

Research History

1994 - 2010

Faculty of Engineering, Kyoto Sangyo University
2010

- 京都産業大学総合生命科学部教授
2003 - 2008

科学技術振興機構戦略的創造研究推進事業
2005

- 新エネルギ−・産業技術綜合開発機構
1989 - 1994

Faculty of Engineering, Kyoto Sangyo University
1986 - 1989

Kyoto Sangyo University
1982 - 1986

同講師
1977 - 1982

Kansai Medical University
（糖鎖機能活用技術開発）委員会委員
（糖鎖の生物機能の解明と利用技術）研究代表者

Education

Committee Memberships

2003 - 2008

（糖鎖の生物機能の解明と利用技術）研究代表者 2003-2008
2005

新エネルギ−・産業技術綜合開発機構分担研究者 2005-
Apr, 1999

日本糖質学会評議員 1999年4月-
1999

評議員, 日本糖質学会
Apr, 1994

日本生化学会評議員 1994年4月-
1994

評議員, 日本生化学会
科学技術振興機構戦略的創造研究推進事業

Misc.

147

Binding of Galectin-3, a beta-Galactoside-binding Lectin, to MUC1 Protein Enhances Phosphorylation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) and Akt, Promoting Tumor Cell Malignancy

Yugo Mori, Kaoru Akita, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Takeomi Murata, Hiroshi Nakada

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(43) 26125-26140, Oct, 2015
Difference in mesothelin- binding ability of serum CA125 between patients with endometriosis and epithelial ovarian cancer

Aya Sasaki, Kaoru Akita, Fumitake Ito, Taisuke Mori, Jo Kitawaki, Hiroshi Nakada

INTERNATIONAL JOURNAL OF CANCER, 136(8) 1985-1990, Apr, 2015
Susceptibility to proteases of anti-Tn-antigen MLS128 binding glycoproteins expressed in human colon cancer cells

Fumie Oura, Yukiko Yajima, Munehiro Nakata, Kenzui Taniue, Tetsu Akiyama, Hiroshi Nakada, Kazuo Yamamoto, Yoko Fujita-Yamaguchi

BIOSCIENCE TRENDS, 9(1) 49-55, Feb, 2015
MUC1 Protein Induces Urokinase-type Plasminogen Activator (uPA) by Forming a Complex with NF-kappa B p65 Transcription Factor and Binding to the uPA Promoter, Leading to Enhanced Invasiveness of Cancer Cells

Yugo Mori, Kaoru Akita, Shuhei Tanida, Akiko Ishida, Munetoyo Toda, Mizue Inoue, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa, Hiroshi Nakada

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(51) 35193-35204, Dec, 2014
Knock Out of S1P3 Receptor Signaling Attenuates Inflammation and Fibrosis in Bleomycin-Induced Lung Injury Mice Model

Ken Murakami, Masataka Kohno, Masatoshi Kadoya, Hidetake Nagahara, Wataru Fujii, Takahiro Seno, Aihiro Yamamoto, Ryo Oda, Hiroyoshi Fujiwara, Toshikazu Kubo …

PLOS ONE, 9(9), Sep, 2014
Negative Regulation of Toll-like Receptor-4 Signaling through the Binding of Glycosylphosphatidylinositol-anchored Glycoprotein, CD14, with the Sialic Acid-binding Lectin, CD33

Akiko Ishida, Kaoru Akita, Yugo Mori, Shuhei Tanida, Munetoyo Toda, Mizue Inoue, Hiroshi Nakada

JOURNAL OF BIOLOGICAL CHEMISTRY, 289(36) 25341-25350, Sep, 2014
Galectin-3 binds to MUC1-N-terminal domain and triggers recruitment of beta-catenin in MUC1-expressing mouse 3T3 cells

Shuhei Tanida, Yugo Mori, Akiko Ishida, Kaoru Akita, Hiroshi Nakada

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(6) 1790-1797, Jun, 2014
Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of beta-Catenin and Subsequent Cell Growth

Shuhei Tanida, Kaoru Akita, Akiko Ishida, Yugo Mori, Munetoyo Toda, Mizue Inoue, Mariko Ohta, Masakazu Yashiro, Tetsuji Sawada, Kosei Hirakawa …

JOURNAL OF BIOLOGICAL CHEMISTRY, 288(44) 31842-31852, Nov, 2013
Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9

Yasuyuki Matsumoto, Qing Zhang, Kaoru Akita, Hiroshi Nakada, Kazunori Hamamura, Akiko Tsuchida, Tetsuya Okajima, Koichi Furukawa, Keiko Furukawa, Takeshi Urano

Journal of Biological Chemistry, 288(33) 24264-24276, Aug 16, 2013
CA125/MUC16 interacts with Src family kinases, and over-expression of its C-terminal fragment in human epithelial cancer cells reduces cell-cell adhesion

Kaoru Akita, Minarni Tanaka, Shuhei Tanida, Yugo Mori, Munetoyo Toda, Hiroshi Nakada

EUROPEAN JOURNAL OF CELL BIOLOGY, 92(8-9) 257-263, Aug, 2013
Prohibitins function as endogenous ligands for Siglec-9 and negatively regulate TCR signaling upon ligation

Hajime Yurugi, Shuhei Tanida, Kaoru Akita, Akiko Ishida, Munetoyo Toda, Hiroshi Nakada

Biochemical and Biophysical Research Communications, 434(2) 376-381, May 3, 2013
Characterization of anti-Tn-antigen MLS128 binding proteins involved in inhibiting the growth of human colorectal cancer cells

Normaiza Zamri, Naoya Masuda, Fumie Oura, Kazuya Kabayama, Yukiko Yajima, Hiroshi Nakada, Kazuo Yamamoto, Yoko Fujita-Yamaguchi

BioScience Trends, 7(5) 221-229, 2013
Isolation of Fucosyltransferase-Producing Bacteria from Marine Environments

Hitomi Kajiwara, Munetoyo Toda, Toshiki Mine, Hiroshi Nakada, Takeshi Yamamoto

MICROBES AND ENVIRONMENTS, 27(4) 515-518, Dec, 2012
Ikuo Yamashina: a pioneer who established the basis of current glycobiology

Hiroshi Nakada

JOURNAL OF BIOCHEMISTRY, 151(5) 461-468, May, 2012
Different Levels of Sialyl-Tn Antigen Expressed on MUC16 in Patients With Endometriosis and Ovarian Cancer

Kaoru Akita, Shuhei Yoshida, Yuzuru Ikehara, Sayumi Shirakawa, Munetoyo Toda, Mizue Inoue, Jo Kitawaki, Hayao Nakanishi, Hisashi Narimatsu, Hiroshi Nakada

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 22(4) 531-538, May, 2012
Expression of prohibitins on the surface of activated T cells

Hajime Yurugi, Shuhei Tanida, Akiko Ishida, Kaoru Akita, Munetoyo Toda, Mizue Inoue, Hiroshi Nakada

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 420(2) 275-280, Apr, 2012
pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen

Yasuyuki Matsumoto, Qing Zhang, Kaoru Akita, Hiroshi Nakada, Kazunori Hamamura, Noriyo Tokuda, Akiko Tsuchida, Takeshi Matsubara, Tomoko Hori, Tetsuya Okajima …

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 419(1) 7-13, Mar, 2012
Overproduction of anti-Tn antibody MLS128 single-chain Fv fragment in Escherichia coli cytoplasm using a novel pCold-PDI vector

Ganesh P. Subedi, Tadashi Satoh, Shinya Hanashima, Akemi Ikeda, Hiroshi Nakada, Reiko Sato, Mamoru Mizuno, Noriyuki Yuasa, Yoko Fujita-Yamaguchi, Yoshiki Yamaguchi

PROTEIN EXPRESSION AND PURIFICATION, 82(1) 197-204, Mar, 2012
Surface plasmon resonance and NMR analyses of anti Tn-antigen MLS128 monoclonal antibody binding to two or three consecutive Tn-antigen clusters

Ayano Matsumoto-Takasaki, Shinya Hanashima, Ami Aoki, Noriyuki Yuasa, Haruhiko Ogawa, Reiko Sato, Hiroko Kawakami, Mamoru Mizuno, Hiroshi Nakada, Yoshiki Yamaguchi …

JOURNAL OF BIOCHEMISTRY, 151(3) 273-282, Mar, 2012
Effects of two monoclonal antibodies, MLS128 against Tn-antigen and 1H7 against insulin-like growth factor-I receptor, on the growth of colon cancer cells

Normaiza Zamri, Naoya Masuda, Fumie Oura, Yukiko Yajima, Hiroshi Nakada, Yoko Fujita-Yamaguchi

BIOSCIENCE TRENDS, 6(6) 303-312, 2012

Books and Other Publications

炎症と免疫; 免疫応答に対するムチンの影響

先端医学社, 2014
Trends in Glycoscience and Glycotechnology,Vol22；Immunosuppressive effect of carcinoma-produced mucins on B cell function

FCCA, 2010
Experimental Glycoscience；Biological significance of mucins produced by epithelial cancer cells. Experimental Glycoscience

Springer, 2008
蛋白核酸酵素53巻；ムチンを介した腫瘍細胞の増殖・進展

共立出版, 2008
未来を拓く糖鎖科学；上皮性癌細胞の産生するムチンの生物学的意義

金芳堂, 2005
糖鎖科学の新展開-機能解明・次世代型材料・医薬品開発に向けて；O-グリカンおよびムチンの性質と生物学的機能

株式会社NTS, 2005
生化学第77巻；上皮性癌細胞の産生するムチンの特性と腫瘍組織における生物学的意

日本生化学会, 2005
遺伝子医学、MOOK3「病気と糖鎖」上皮性癌細胞の産生するムチンの特性と機能

メディカル・ドゥ, 2005
Structural and immunocytochemical studies on a-N-acetylgalactosaminidase deficiency (Schindler/Kanzaki disease).

J. Hum. Genet.,, 2004
The receptor and transporter for internalization of Clostridium botsulinum type C progenitor toxin into HT-29 cells.

Biochem. Biophys. Res. Commun., 2004
Heparan sulphate proteoglycans interact with Neurocan and promote neurite outgrowth from cerebellar granule cells.

Biochem. J.,, 2004
Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells.

Proc. Natl. Acad. Sci. USA,, 2003
Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo 201 cells.

J. Biochem.,, 2003
T. Nakada, H.Sano, Y. Kawahito, T.Hla, K. Akito, M. Toda, I. Yamashina, M. Inoue Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells

Proc. Natl. Acad. Sci. USA, 2003
わかる実験医学シリーズ、糖鎖生物学がわかる；ムチンおよびムチン型糖鎖の多様性とその意義

羊土社, 2002
Biosynthetic pathways of O-glycans. In Handbook of Glycosyltransferases and Their Related Genes

Springer-Verlag, 2001
H. Nakada Biosynthetic pathways of o-glycans

Handbook of Glycosyltransferases and Thein Related Genes, 2001
K. Akita, S.Fushiki, T.Fujimoto, S.MUnesue, M.Inoue, K. Oguri, M. Okayama, I. Yamashina and H. Nakada Identification of the coveprotein carrying the Tn antigen in mouse brain: Specific expression on syndecan-3

Cell Struct. Funct., 2001
K. Akita, S. Fushiki, T. Fujimoto, M.Inoue, K.Oguri, M. Okayama, I.Ymashina and H. Nakada, Devolopmental expression of a unique carbohydrate antigen, Tn antigen, in mouse central nervous tissues.

J. Neurosci., 2001
著者 : M. Inoue, S. Takahashi, I. Yamashina, M. Kaibori, T. Okumura, Y. Kamiyama, S. V. Guerre, D. Cantacuzene H. Nakada High density o-Glycosylation of the Muc2 taudem repeat unit by N-acetylgalactosaminyltransferase-3 in colonic adenocarcinoma extract

Cancer Res, 2001

Presentations

138

癌組織微小環境におけるMUC1—レクチン相互作用による腫瘍悪性化

第74回日本癌学会, 2015
シグレック−9と新規カウンターリセプターとの相互作用がもたらす生物学的作用

Glyco-Immunology 2015, 2015
MUC1へのgalectin-3の結合を介した情報伝達が癌悪性化機構を誘導する。

第34回日本糖質学会, 2015
子宮内膜症患者と卵巣癌患者間における血清CA125のメソテリン結合能の違い

第87回日本生化学会大会, 2014
MUC1はNF-κBと複合体を形成しプロモーターに結合することでuPAの発現を誘導する

第73回日本癌学会学術総会, 2014
ムチンの生物学的機能の解析と医薬への展望

第66回日本生物工学会大会, 2014
MUC1はNF-κBと複合体を形成し、プロモーターに結合することでuPAの発現を誘導し、癌細胞浸潤能を亢進させる

第33回日本糖質学会年会, 2014
MUC1による腫瘍悪性化機構

第33回日本糖質学会年会, 2014
膜結合型ムチンMUC1とシアル酸結合レクチンSiglec-9の結合はMUC1とβ-cateninの相互作用および細胞増殖を促進する

第61回日本生化学会近畿支部例会, 2014
MUC1によるuPAの発現誘導及び悪性化機構

第61回日本生化学会近畿支部例会, 2014
シグレック-3によるTLR-4情報伝達の制御

糖鎖免疫2014, 2014
MUC1発現細胞におけるuPAの誘導

第72回日本癌学会学術総会, 2013
Characterization of anti-Tn-antigen MLS128 binding proteins involved in growth inhibitory effects on human colon cancer cells

第86回日本生化学会大会, 2013
CD14 と Siglec-3 の結合による Toll-like receptor-4 シグナル伝達の抑制

第86回日本生化学会大会, 2013
MUC1発現によるuPAの発現誘導

第86回日本生化学会大会, 2013
シグレック-9によるプロヒビチンを介したTCRシグナル伝達の抑制

第32回日本糖質学会年会, 2013
Interaction between Siglec-9 and prohibitins down-regulates T cell receptor signaling

The 15th International Congress of Immunology, 2013
MUC1発現細胞におけるウロキナーゼの発現誘導

第22回日本がん転移学会学術集会, 2013
ヒト大腸がん細胞LS180の細胞増殖に対するT抗原特異的Peanut agglutinin lectin (PNA)の効果：抗Tn抗原モノクロール抗体MLS128との相互作用の可能性

第85回日本生化学会大会, 2012
シグレック-9とプロヒビチンの相互作用によるT細胞受容体を介したシグナル伝達の制御

第85回日本生化学会大会, 2012

Professional Memberships

Works

Production of monoclonal antibody recognizing carbohybrate antigens

1990 - 1995

Research Projects

上皮性癌細胞の産生するムチンの生物学的意義

科学研究費補助金, 1990 - 2020
Expression and biological significance of cancer-associated carbohydrate antigen

Grant-in-Aid for Scientific Research, 1990 - 2014

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Misc.

Books and Other Publications

Presentations

Professional Memberships

Works

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