2006年
Arctigenin from Fructus Arctii is a novel suppressor of heat shock response in mammalian cells.
Cell stress & chaperones
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- 巻
- 11
- 号
- 2
- 開始ページ
- 154
- 終了ページ
- 61
- 記述言語
- 英語
- 掲載種別
- Scientific Journal
- DOI
- 10.1379/CSC-148R.1
Because heat shock proteins (Hsps) are involved in protecting cells and in the pathophysiology of diseases such as inflammation, cancer, and neurodegenerative disorders, the use of regulators of the expression of Hsps in mammalian cells seems to be useful as a potential therapeutic modality. To identify compounds that modulate the response to heat shock, we analyzed several natural products using a mammalian cell line containing an hsp promoterregulated reporter gene. In this study, we found that an extract from Fructus Arctii markedly suppressed the expression of Hsp induced by heat shock. A component of the extract arctigenin, but not the component arctiin, suppressed the response at the level of the activation of heat shock transcription factor, the induction of mRNA, and the synthesis and accumulation of Hsp. Furthermore, arctigenin inhibited the acquisition of thermotolerance in mammalian cells, including cancer cells. Thus, arctigenin seemed to be a new suppressive regulator of heat shock response in mammalian cells, and may be useful for hyperthermia cancer therapy.
- リンク情報
- ID情報
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- DOI : 10.1379/CSC-148R.1
- ISSN : 1355-8145
- CiNii Articles ID : 30015396998
- PubMed ID : 16817321
- PubMed Central 記事ID : PMC1484516