2006年11月
The phenylic hydroxyl group is essential for the induction of stress response by sodium salicylate
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 350
- 号
- 1
- 開始ページ
- 131
- 終了ページ
- 137
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.bbrc.2006.09.008
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
We have shown that sodium salicylate (SA) activates the heat shock promoter and induces the expression of heat shock proteins (Hsps) with a concomitant increase in the thermotolerance of cells. To identify the functional groups of SA necessary for the induction of Hsps, we evaluated the effect of various derivatives of SA using a mammalian cell line containing a reporter gene downstream of an hsp105 promoter. Among the derivatives, the compounds in which the carboxyl group of SA was substituted activated the hsp105 promoter at 37 degrees C as SA did, but the compounds in which the hydroxyl group was substituted did not. Thus, the phenylic hydroxyl group but not the carboxyl group of SA seemed to be necessary for a stress-induced response. In addition, the orientation of two functional groups on the benzene ring of SA derivatives was also important for the induction of a response. Among these compounds, salicylalcohol which strongly induced the expression of Hsps suppressed the protein aggregation and apoptosis caused by an expanded polyglutamine tract in a cellular model of polyglutamine disease. These findings may aid in the development of novel effective Hsp-inducers. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
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- DOI
- https://doi.org/10.1016/j.bbrc.2006.09.008
- CiNii Articles
- http://ci.nii.ac.jp/naid/80018866811
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/16996033
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000241212700018&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1016/j.bbrc.2006.09.008
- ISSN : 0006-291X
- CiNii Articles ID : 80018866811
- PubMed ID : 16996033
- Web of Science ID : WOS:000241212700018