MISC

1992年

BINDING OF I-125 ENDOTHELIN-1 TO FAT-STORING CELLS IN RAT-LIVER REVEALED BY ELECTRON-MICROSCOPIC AUTORADIOGRAPHY

ANATOMY AND EMBRYOLOGY
  • S FURUYA
  • ,
  • S NARUSE
  • ,
  • T NAKAYAMA
  • ,
  • K NOKIHARA

185
1
開始ページ
97
終了ページ
100
記述言語
英語
掲載種別
出版者・発行元
SPRINGER

Localization of intravenously injected [I-125]-endothelin-1 was examined in rat liver by light and electron microscopic radioautography. At 10 min after injection, silver grains were localized along the sinusoidal wall, i.e., mostly on the thin processes of fat-storing cells and sinusoidal endothelial cells, and also on the Kupffer cells and the microvilli of hepatocytes. About 35% of the total silver grains were located on the processes of fat-storing cells at 10 min. The grain density (number of silver grains/cell area) of fat-storing cells was three-fold that of Kupffer cells, and 18-fold that of hepatocytes. At 60 min, 60% of the total grains were observed on the fat-storing cells, though the value of grain density was not changed. Silver grains were internalized into the cytoplasm of fat-storing cells and often associated with multivesicular bodies. In contrast, the grain density of endothelial cells and Kupffer cells decreased with time. These results indicate that hepatic fat-storing cells have a considerable number of endothelin-binding sites, and incorporate bound endothelin into cytoplasm.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1992GR87400010&DestApp=WOS_CPL
ID情報
  • ISSN : 0340-2061
  • Web of Science ID : WOS:A1992GR87400010

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