ANDO Kiyoshi

J-GLOBAL         Last updated: Oct 28, 2019 at 10:40
ANDO Kiyoshi
Central Institute for Experimental Animals
Job title
Ph.D., in Medicine(Gunma University, Medical School), Ph.D., in Psychology(Keio University, Graduate School)


My study history is as it follows.

My academic interest and the start of scientific research were on psychometrics and the experimental analysis of behavior in the undergraduate and graduate courses of the Department of Psychology, Keio University, Tokyo, Japan.

In Preclinical Research Laboratories of Central Institute for Experimental Animals, Kawasaki, Japan, I started researches on behavioral pharmacology, psychopharmacology and drug dependence using rhesus monkeys and rats under the direction of Dr. Tomoji Yanagita.

I also studied on neurobehavioral pharmacology using rhesus monkeys at the laboratory (director: Professor Richard R. Schuster) in the department of Pharmacology and Physiological Sciences, Pritzker School of Medicine, the University of Chicago, Chicago, USA. I had another chance to study on the brain imaging in relation with behavior using primates (director: Dr. Tetsuya Suhara) at the Molecular Imaging Laboratory in the National Institute of Radiological Sciences, Chiba, Japan.

Presently, I am doing research on preclinical studies on Parkinson's disease using a small experimental primate, the common marmoset, in Central Institute for Experimental Animals which had been founded 60 years ago by Dr. Tatsuji Nomura with his special ambition for and devotion to the development of useful laboratory animals for the purpose of promoting "in vivo medical sciences".

Research Areas



Keio University
Master Course & Doctoral Course, Department of Psychology,, Keio University, Graduate School,

Published Papers

Measurement of locomotion baseline and other behavioral traits in a common marmoset model of Parkinson’s disease established by a single administration regimen of MPTP - Providing reference data for efficacious preclinical evaluations -
Ando K, Inoue T, Hikoshima K, Komaki Y, Kawai K, Inoue R, Nishime C, Nishinaka E Urano K, Okano H
Behavioural Pharmacology (in Press)      [Refereed]
Ando K, Nishime C, Inoue R, Nishinaka E, Kawai K, Urano K, Tsutsumi H
Behavioural pharmacology   28(8) 670-680   Dec 2017   [Refereed]
Hikishima K, Ando K, Komaki Y, Kawai K, Yano R, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H
Neuroscience   300 585-592   Aug 2015   [Refereed]
Hikishima K, Ando K, Yano R, Kawai K, Komaki Y, Inoue T, Itoh T, Yamada M, Momoshima S, Okano HJ, Okano H
Radiology   140601   Jan 2015   [Refereed]
Ando K, Inoue T, Itoh T
Pharmacology, biochemistry, and behavior   127 62-69   Dec 2014   [Refereed]
Ando K, Obayashi S, Nagai Y, Oh-Nishi A, Minamimoto T, Higuchi M, Inoue T, Itoh T, Suhara T
PloS one   7 e46371   2012   [Refereed]
Nagai Y, Minamimoto T, Ando K, Obayashi S, Ito H, Ito N, Suhara T
Neuroscience research   73(1) 61-67   May 2012   [Refereed]
Behavioral analysis in preclinical studies for neuropsychiatric diseases using nonhuman primates
ANDO Kiyoshi
Experimental Medicine   30(2) 121-127   2012   [Invited]
Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T
The Journal of neuroscience : the official journal of the Society for Neuroscience   28 12255-12267   Nov 2008   [Refereed]
Ando K, Maeda J, Inaji M, Okauchi T, Obayashi S, Higuchi M, Suhara T, Tanioka Y
Psychopharmacology   195(4) 509-516   Jan 2008   [Refereed]
Parkinson's disease model in the common marmoset
ANDO Kiyoshi
82-86   2008   [Invited]
Nagai Y, Obayashi S, Ando K, Inaji M, Maeda J, Okauchi T, Ito H, Suhara T
Synapse (New York, N.Y.)   61 809-819   Oct 2007   [Refereed]
Yasuno F, Ota M, Ando K, Ando T, Maeda J, Ichimiya T, Takano A, Doronbekov TK, Fujimura Y, Nozaki S, Suhara T
Biological psychiatry   61 1252-1259   Jun 2007   [Refereed]
Haneda E, Higuchi M, Maeda J, Inaji M, Okauchi T, Ando K, Obayashi S, Nagai Y, Narazaki M, Ikehira H, Nakao R, Zhang MR, Suzuki K, Suzuki H, Suhara T
Synapse (New York, N.Y.)   61 205-215   Apr 2007   [Refereed]
Inaji M, Okauchi T, Ando K, Maeda J, Nagai Y, Yoshizaki T, Okano H, Nariai T, Ohno K, Obayashi S, Higuchi M, Suhara T
Brain research   1064 136-145   Dec 2005   [Refereed]
Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, Yamasaki M, Momoshima S, Ishii H, Ando K, Tanioka Y, Tamaoki N, Nomura T, Toyama Y, Okano H
Journal of neuroscience research   80 182-190   Apr 2005   [Refereed]
Inaji M, Yoshizaki T, Okauchi T, Maeda J, Nagai Y, Nariai T, Ohno K, Ando K, Okano H, Obayashi S, Suhara T
Cell transplantation   14 655-663   2005   [Refereed]
Takano A, Suhara T, Maeda J, Ando K, Okauchi T, Obayashi S, Nakayama T, Kapur S
Psychiatry and clinical neurosciences   58(3) 330-332   Jun 2004   [Refereed]
Yoshizaki T, Inaji M, Kouike H, Shimazaki T, Sawamoto K, Ando K, Date I, Kobayashi K, Suhara T, Uchiyama Y, Okano H
Neuroscience letters   363 33-37   Jun 2004   [Refereed]
Effects of vinconate on scopolamine-induced memory impairment in rhesus monkeys.
Ando K, Hironaka N, Shuto K
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology   23 43-46   Feb 2003   [Refereed]
Brain regions mediating the discriminative stimulus effects of nicotine in rats.
Miyata H, Ando K, Yanagita T
Annals of the New York Academy of Sciences   965 354-363   Jun 2002   [Refereed]
Miyata H, Ando K, Yanagita T
Psychopharmacology   145(2) 234-236   Jul 1999   [Refereed]
Effects of cholinergic drugs on scopolamine-induced memory impairment in rhesus monkeys.
Hironaka N, Ando K
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology   16 103-108   Jun 1996   [Refereed]
Ando K, Miyata H, Yanagita T
Japanese journal of pharmacology   64(1) 35-40   Jan 1994   [Refereed]
The discriminative effects of nicotine and their central sites in rats.
Ando K, Miyata H, Hironaka N, Tsuda T, Yanagita T
Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology   13 129-136   Jun 1993   [Refereed]
Hironaka N, Miyata H, Ando K
Japanese journal of pharmacology   59(1) 113-120   May 1992   [Refereed]
Ando K, Yanagita T
Pharmacology, biochemistry, and behavior   41(4) 783-788   Apr 1992   [Refereed]
Ando K, Johanson CE, Schuster CR
Pharmacology, biochemistry, and behavior   26(1) 103-109   Jan 1987   [Refereed]
Ando K, Johanson CE, Schuster CR
Pharmacology, biochemistry, and behavior   24(3) 693-699   Mar 1986   [Refereed]
Development of cigarette smoking in rhesus monkeys.
Ando K, Hironaka N, Yanagita T
NIDA research monograph   67 147-153   1986
Ando K, Johanson CE, Seiden LS, Schuster CR
Pharmacology, biochemistry, and behavior   22(5) 737-743   May 1985   [Refereed]
Psychopharmacological studies on nicotine and tobacco smoking in rhesus monkeys.
Yanagita T, Ando K, Kato S, Takada K
Psychopharmacology bulletin   19 409-412   1983   [Refereed]
Cigarette smoking in rhesus monkeys.
Ando K, Yanagita T
Psychopharmacology   72 117-127   1981   [Refereed]
Trialwise tracking method for measuring drug-affected sensory threshold changes in animals.
Ando K, Takada K
Neurobehavioral toxicology   1 Suppl 1 45-52   1979   [Refereed]
The discriminative stimulus properties of intravenously administered cocain in rhesus monkeys
Ando K, Yanagita T
Stimulus Properties of Drugs:Ten Years of Progress. eds by Colpaert F and Rosecrans J Elsevier/North-Holland   125-136   1978   [Invited]
Chiba S, Ando K
Japanese journal of pharmacology   26(4) 419-426   Aug 1976   [Refereed]
Profile of drug effects on temporally spaced responding in rats.
Ando K
Pharmacology, biochemistry, and behavior   3 833-841   Sep 1975   [Refereed]
The discriminative control of operant behavior by intravenous administration of drugs in rats.
ANDO Kiyoshi
Psychopharmacologia (Berl.)   45 47-50   1975   [Refereed]

Conference Activities & Talks

Behavioral pharmacological effects of dopaminergic drugs in common marmosets pretreated with subcutaneous MPTP or intracerebral 6-OHDA
ANDO Kiyoshi et al
The Society for Neuroscience 2014, Washington DC. 19 November 2014   19 Nov 2014   
Behavioral baseline of the MPTP-treated common marmoset in preclinical studies on Parkinson's disease.
ANDO Kiyoshi et al
The Society for Neuroscience 2013, San Diego.   11 Nov 2013   
Measurement of cognitive function in the common marmoset using iPad.
ANDO Kiyoshi et al
The 43th Annual Meeting of Japanese Society for Neuropsychopharmacology, Ginowan.   26 Oct 2013   
MPTP-induced Parkinson's disease model of the common marmoset as a guidepost and a stepping stone in developing neurodegenerative models in nonhuman primates. [Invited]
ANDO Kiyoshi
2013 KALAS International Symposium, Jeju island.   22 Aug 2013   
Establishment of MPTP-induced parkinson's disease model in cynomolgus monkeys and common marmosets. [Invited]
ANDO Kiyoshi
Seoul National University Hospital, Seoul.   Jun 2012   
Parkinson's disease model in MPTP-treated common marmoset. -In vivo imaging of neural degeneration and behavioral manifestation of Parkinsonism-. [Invited]
ANDO Kiyoshi
Workshop held by Korean Food and Drug Administration, National Institute of Food and Drug Service Korea, Seoul.   Jun 2012   
Changes in cognitive function of MPTP-treated common marmosets of Parkinson’s disease model.
ANDO Kiyoshi et al
The Society for Neuroscience 2011, Wshingtong DC.   Nov 2011   
MPTP パーキンソン病モデル・マーモセットの認知機能障害.
安東 潔 他
第41 回日本神経精神薬理学会学術年会, 東京.   Oct 2011   
霊長類を用いた in vivo 実験医学 パーキンソン病モデルの作製. [Invited]
安東 潔
第4回in vivo実験医学シンポジウム, In vivo実験医学今後の展望東京.   Feb 2011   
In vivo MRI analysis of MPTP-induced parkinsonian marmoset brains.
ANDO Kiyoshi et al
The Society for Neuroscience 2010, San Diego.   Nov 2010   
MPTP投与パーキンソン病モデル・マーモセット脳の MRI による in vivo 解析.
ANDO Kiyoshi et al
第40回日本神経精神薬理学会学術年会, 仙台.   Sep 2010   
Objective measurement of dyskinesias produced by repeated administration of L-dopa in MPTP-treated parkinsonian marmosets.
ANDO Kiyoshi et al
The Society for Neuroscience 2009, Chicago.   Oct 2009   
パーキンソン病モデル・マーモセットへの L-DOPA投与によるジスキネジア(反復不随意運動など)の測定.
安東 潔 他
第39回日本神経精神薬理学会学術年会,京都市.   Sep 2009   
薬効評価研究に利用されるマーモセット・パーキンソン病モデルの特性〜カニクイザル・モデルとの比較〜. [Invited]
安東 潔
SORSTシンポジウム「遺伝子改変マーモセット研究の新展開」,独立行政法人 科学技術振興機構,東京.   Apr 2009   
In vivo PET測定により検出されたマーモセット脳の神経変性とパーキンソン病様症候発現強度の高相関性.
安東 潔 他
第82回日本薬理学会学術年会, 横浜.   Mar 2009   
In vivo PET analysis of parkinsonian marmoset brains.
ANDO Kiyoshi et al
The Society for Neuroscience 2008, Washington DC.   Nov 2008   
PET および MRI によるパーキンソン病モデル・マーモセット脳の in vivo 解析.
安東 潔 他
第38回日本神経精神薬理学会学術, 東京.   Oct 2008   
サル類の神経精神疾患モデルを用いた前臨床研究〜アカゲザルからコモンマーモセットへ〜. [Invited]
安東 潔
脳科学研究戦略推進プログラム課題C,京都.   Oct 2008   
神経変性と症候発現に関して疾患類似性のあるパーキンソン病モデル. [Invited]
安東 潔
ゲノム解析からIn vivo 解析への回帰, つくば市.   Nov 2007   
神経変性と症候発現に関して 疾患類似性のあるパーキンソン病モデル [Invited]
安東 潔
第1回in vivo実験医学シンポジウムシンポジウム, ゲノム解析から in vivo 解析への回帰.   Nov 2007   
Relationship between degrees of parkinsonism and striatal dopamine neural damage in MPTP-treated common marmosets.
ANDO Kiyoshi et al
The Society for Neuroscience 2007, San Diego.   Nov 2007   
安東 潔 他
第37回日本神経精神薬理学会学術年会, 札幌   Jul 2007   
安東 潔 他
第80回日本薬理学会学術年会, 名古屋.   Mar 2007   
MPTP-induced Parkinson’s disease model in common marmosets and cynomolgus monkey.
ANDO Kiyoshi et al
The Society for Neuroscience 2006, Atlanta.   Oct 2006   
サル類における認知機能研究 [Invited]
安東 潔
認知神経科学会, 東京.   Jul 2006   
Deprenyl protected neural damage partially but showed marked attenuation of parkinsonism in MPTP-treated common marmosets.
ANDO Kiyoshi et al
第79回日本薬理学会年会学術年会, 横浜.   Mar 2006   
In vivo 神経精神疾患モデルのコンセプトについて考える. [Invited]
安東 潔
薬物・精神・行動の会.   Dec 2005   
Neurobehavioral protection of single dose deprenyl against MPTP toxicity in marmosets.
ANDO Kiyoshi et al
The Society for Neuroscience 2005, Washington D.C.   Nov 2005   
Neuroprotective action of single dose deprenyl against MPTP-induced parkinsonism in common marmosets
ANDO Kiyoshi et al
The 35th Japanese Society of Neuropsychopharmacology, Osaka.   Jul 2005   
鎮咳薬合剤摂取時の自覚効果を動物で検索する. [Invited]
安東 潔
ミニシンポジウム「鎮咳剤乱用をめぐって」, 嗜癖行動学会, 松本.   Oct 2004   
Progressive degeneration of dopamine neurons detected by PET after repeated administration of MPTP in crab-eating monkeys.
ANDO Kiyoshi et al
第77回日本薬理学会学術年会, 大阪.   Mar 2004   
Behavioral effects of nicotine. [Invited]
ANDO Kiyoshi
日本神経精神薬理学会学術年会.   Oct 2003   



Preclinical drug evaluation studies on Parkinson's disease have been performed using the common marmoset model with pharmaceutical companies.