MISC

1995年9月

FAILURE OF GENOTOXIC CARCINOGENS TO PRODUCE TUMORS IN HUMAN SKIN XENOGRAFTS TRANSPLANTED TO SCID MICE

CARCINOGENESIS
  • K URANO
  • ,
  • Y KATAKAI
  • ,
  • Y TOKUDA
  • ,
  • Y UEYAMA
  • ,
  • T NOMURA
  • ,
  • S YAMAMOTO

16
9
開始ページ
2223
終了ページ
2226
記述言語
英語
掲載種別
DOI
10.1093/carcin/16.9.2223
出版者・発行元
OXFORD UNIV PRESS UNITED KINGDOM

Chemical carcinogenesis of human skin was investigated using human skin xenografts (16 full thickness and 48 split thickness skin grafts) transplanted to CB-17-scid (SCID) mice. Topical application of a carcinogen, i.e. 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene, methylcholanthrene or N-methyl-N'-nitro-N-nitrosoguanidine, to the human skin xenografts once a week for 25-30 weeks failed to produce skin tumors. Both DMBA application plus UVB irradiation and alternate applications of the above four carcinogens in combination with UV-B irradiation also failed to produce tumors. All of these treatments induced skin papillomas in skins of host SCID mice. DMBA induced skin papillomas in allogenic CD-1 mouse skin grafts transplanted to SCID mice. These results indicate that susceptibility of human skin to these carcinogenic stimuli is much lower than that of mouse skin.

Web of Science ® 被引用回数 : 11

リンク情報
DOI
https://doi.org/10.1093/carcin/16.9.2223
CiNii Articles
http://ci.nii.ac.jp/naid/80008547107
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1995RV29600033&DestApp=WOS_CPL