2002年1月
Isolation of a novel cyclic hexadepsipeptide pipalamycin from Streptomyces as an apoptosis-inducing agent
JOURNAL OF ANTIBIOTICS
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- 巻
- 55
- 号
- 1
- 開始ページ
- 1
- 終了ページ
- 5
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.7164/antibiotics.55.1
- 出版者・発行元
- JAPAN ANTIBIOT RES ASSN
The novel cyclic hexadepsipeptide named pipalamycin was isolated from a culture filtrate of Streptomyces sp. ML297-90F8 as an apoptosis-inducing agent. The antibiotic was found to be consisting of each one mole of alanine, N-hydroxyalanine, glycine, N-acylated 3-hydroxyleucine, and two moles of piperazic acid. Pipalamycin induced apoptosis in apoptosis-resistant human pancreatic adenocarcinoma AsPC-1 cells at 0.3 mug/ml in 24similar to48 hours. It also showed antibacterial activity on Gram-positive bacteria such as Staphylococcus aureus and Micrococcus luteus. Fermentation, isolation, structural elucidation and the biological activities of pipalamycin are described.
- リンク情報
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- DOI
- https://doi.org/10.7164/antibiotics.55.1
- CiNii Articles
- http://ci.nii.ac.jp/naid/10008471735
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/11918058
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000173536100001&DestApp=WOS_CPL
- ID情報
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- DOI : 10.7164/antibiotics.55.1
- ISSN : 0021-8820
- CiNii Articles ID : 10008471735
- PubMed ID : 11918058
- Web of Science ID : WOS:000173536100001