SHIMAMOTO Keiko

J-GLOBAL         Last updated: Oct 30, 2018 at 19:13
 
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Name
SHIMAMOTO Keiko
Affiliation
SUNTORY FOUNDATION FOR LIFE SCIENCES
Job title
Researcher
Degree
(BLANK)(Osaka University)

Research Areas

 
 

Academic & Professional Experience

 
1986
 - 
2002
Researcher, Suntory Institute for Bioorganic
 
 
   
 
Research
 

Published Papers

 
K. Fujikawa, S. Suzuki, R. Nagase, S. Ikeda, S. Mori, K. Nomura, K. Nishiyama, K. Shimamoto.
ACS Chem. Biol.   13 2719-2727   2018   [Refereed]
R. Suno, K. T. Kimura, T. Nakane, K. Yamashita, J. Wang, T. Fujiwara, Y. Yamanaka, D. Im, S. Horita., H. Tsujimoto, M.S. Tawaramoto, T. Hirokawa, E. Nango, K. Tono, T. Kameshima, T. Hatsui, Y. Joti, M. Yabashi, K. Shimamoto, M. Yamamoto, D.M. Rosenbaum, S. Iwata, T. Shimamura, T. Kobayashi
Structure   26 7-19   2018   [Refereed]
T. Miyazaki, M. Yamasaki, K. Hashimoto, K. Kohda K, M. Yuzaki, K. Shimamoto, K. Tanaka, M. Kano, M. Watanabe
Proc Natl Acad Sci U S A   114 7438-7443   2017   [Refereed]
K. Nomura, Y. Tanimoto, F. Hayashi, E. Harada, X.Y. Shan, M. Shionyu, A. Hijikata, T. Shirai, K. Morigaki, K. Shimamoto
Angew Chem Int Ed Engl.   56 270-274   2017   [Refereed]
SHIMAMOTO Keiko
Bull. Chem. Soc. Jpn.   89 282-295   2016   [Refereed][Invited]

Misc

 
Shigeri Y, Shimamoto K
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   127 279-287   Apr 2006   [Refereed]
Pharmacological Properties of the Potent Eotent Epileptogenic Amino Aciol Dysiherbaine, a novel Glutamate Recepta Agonist lsolated from the Marine Sponge Dysidea herbacea(jointly worked)
The Journal of Pharmacology and Experimental Therapeutics   296, 655    2001
Characterization of the glutamatergic system for induction and maintenance of allodynia(jointly worked)
895-178    2001
Competitive blockers for the glutamate/aspartate transporter(jointly worked)
Neurochem Research   24 139   1999

Conference Activities & Talks

 
Novel glycolipid involved in membrane protein integration [Invited]
SHIMAMOTO Keiko
The 11th international symposium on integrated synthesis (ISONIS-11) & The 3rd international symposium middle molecular strategy (ISMMS-3)   17 Nov 2017   
Identification of a Novel Glycolipid Essential for Membrane Protein Integration [Invited]
SHIMAMOTO Keiko
24 Mar 2016   

Works

 
Molecular mechanizm on excitatory neurotransmission
1999
Preparation of affinity column for isolation of glutamate transporter
1999

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2010 - 2012    Investigator(s): Keiko SHIMAMOTO
We have found a novel integration factor in the inner membrane of E. coli, naming it MPIase (membrane protein integrase). MPIase turned out to be a glycolipid composed of diacylglycerol and a glycan chain of three acetylated aminosugars linked thr...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2007 - 2009    Investigator(s): Keiko SHIMAMOTO
Extracellular concentrations of amino acids and sugars are regulated by transporters. In order to elucidate physiological roles in neurotransmission system and substrate recognition mechanisms of these transporters, we synthesized selective inhibi...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2004 - 2006    Investigator(s): Keiko SHIMAMOTO
Glutamate is a major excitatory neurotransmitter in mammalian central nervous systems and is linked to higher brain functions such as memory and learning. Glutamate is concentrated into synaptic vesicles through Vesicular Glutamate Transporters (V...
Molecular Mechanistic Study on Excitatory Amino Acid Neurotransmission

Patents

 
Beta-hydroxy aspartic acid derivatives
EP 0 844 234 A2