1995年
SYNTHESIS OF ALPHA-AMINOPHOSPHONIC OCTAPEPTIDE, PHE-GLY-SER-LEU-ALA(P)-PHL-LEU-PRO, AN ANALOG WITH PARTIAL SEQUENCE OF ERB B-2 GENE-PRODUCT
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
- ,
- ,
- ,
- 巻
- 68
- 号
- 3
- 開始ページ
- 942
- 終了ページ
- 949
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1246/bcsj.68.942
- 出版者・発行元
- CHEMICAL SOC JAPAN
A chemical synthesis was performed of an octapeptide with a phosphonic ester linkage, which corresponds to a variation of the partial sequence of a gene product of erb B-2. The phosphonic ester linkage was successfully prepared through a coupling reaction of magnesium salt of the hydroxypeptide with phosphonochloridate, without damage of the peptide bond. The free aminophosphonic peptide as the final product gave a single peak on the ODS column, and a reasonable ratio of the component amino acids. The reaction series exploited here might be useful as a general procedure for preparation of the phosphonic peptide.
- リンク情報
- ID情報
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- DOI : 10.1246/bcsj.68.942
- ISSN : 0009-2673
- eISSN : 1348-0634
- CiNii Articles ID : 10008887944
- Web of Science ID : WOS:A1995QQ90400037