Keiko Unno

Profile Information

Affiliation: Visiting Associate Professor, Tea Science Center, University of Shizuoka

Degree: Ph.D.

J-GLOBAL ID: 200901050944951640
researchmap Member ID: 1000150186

Research Interests

Research Areas

Committee Memberships

評議委員, 老化促進モデルマウス(SAM)研究協議会

Awards

May, 2019

O-CHA Pioneer Award, Academic Research Grand Prize, World Green Tea Association

Keiko Unno
2010

日本抗加齢医学会優秀演題賞
2009

茶学術研究会学術奨励賞

Papers

Enokitake Mushroom and Its Active Component, Adenosine, Which Restores Testosterone Production in Impaired and Fatigued Mouse Models.

Kazuaki Iguchi, Koji Nagashima, Jun Mochizuki, Hiroyuki Yamamoto, Keiko Unno, Noriyuki Miyoshi

Nutrients, 15(9), Apr 29, 2023
Improvement of Depressed Mood with Green Tea Intake

Keiko Unno, Daisuke Furushima, Yuya Tanaka, Takeichiro Tominaga, Hirotomo Nakamura, Hiroshi Yamada, Kyoko Taguchi, Toshinao Goda, Yoriyuki Nakamura

Nutrients, 14(14) 2949-2949, Jul 19, 2022
Effect of Combined Ingestion of L-Theanine and L-Arginine for Short-Term Psychological Stress in Young Adults: A Randomized Placebo-Controlled Study.

Daisuke Furushima, Ibuki Sugiyama, Yuzuki Nomura, Keiko Unno, Hiroshi Yamada

Journal of nutritional science and vitaminology, 68(6) 540-546, 2022
L-Arginine Exerts Excellent Anti-Stress Effects on Stress-Induced Shortened Lifespan, Cognitive Decline and Depression.

Monira Pervin, Keiko Unno, Tomokazu Konishi, Yoriyuki Nakamura

International journal of molecular sciences, 22(2), Jan 6, 2021
Theanine, Antistress Amino Acid in Tea Leaves, Causes Hippocampal Metabolic Changes and Antidepressant Effects in Stress-Loaded Mice.

Keiko Unno, Yoshio Muguruma, Koichi Inoue, Tomokazu Konishi, Kyoko Taguchi, Sanae Hasegawa-Ishii, Atsuyoshi Shimada, Yoriyuki Nakamura

International journal of molecular sciences, 22(1), Dec 28, 2020
Mutation in Sodium-Glucose Cotransporter 2 Results in Down-Regulation of Amyloid Beta (A4) Precursor-Like Protein 1 in Young Age, Which May Lead to Poor Memory Retention in Old Age

Keiko Unno, Yoshiichi Takagi, Tomokazu Konishi, Mitsuhiro Suzuki, Akiyuki Miyake, Takumi Kurotaki, Tadashi Hase, Shinichi Meguro, Atsuyoshi Shimada, Sanae Hasegawa-Ishii …

International Journal of Molecular Sciences, 21(15) 5579-5579, Aug 4, 2020 Peer-reviewed
Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids.

Keiko Unno, Daisuke Furushima, Yuzuki Nomura, Hiroshi Yamada, Kazuaki Iguchi, Kyoko Taguchi, Toshikazu Suzuki, Makoto Ozeki, Yoriyuki Nakamura

Molecules (Basel, Switzerland), 25(15), Aug 3, 2020 Peer-reviewed
Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening.

Keiko Unno, Monira Pervin, Kyoko Taguchi, Tomokazu Konishi, Yoriyuki Nakamura

Molecules (Basel, Switzerland), 25(7), Mar 25, 2020
Theanine, the main amino acid in tea, prevents stress-induced brain atrophy by modifying early stress responses

Unno K, Sumiyoshi A, Konishi T, Hayashi M, Taguchi K, Muguruma Y, Inoue K, Iguchi K, Nonaka H, Kawashima R …

Nutrients, 12 174-(DOI: 10.3390/nu12010174), Jan, 2020 Peer-reviewed
Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed SAMP8 Mice.

Onishi S, Meguro S, Pervin M, Kitazawa H, Yoto A, Ishino M, Shimba Y, Mochizuki Y, Miura S, Tokimitsu I …

Nutrients, 11(4) 821-821, Apr, 2019 Peer-reviewed
Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on Females

K. Unno, S. Noda, H. Nii, Y. Kawasaki, K. Iguchi, H. Yamada

Nutrients, Mar, 2019 Peer-reviewed
Stress-Reducing Function of Matcha Green Tea in Animal Experiments and Clinical Trials.

Unno K, Furushima D, Hamamoto S, Iguchi K, Yamada H, Morita A, Horie H, Nakamura Y

Nutrients, 10(10), Oct, 2018 Peer-reviewed
Beneficial Effects of Green Tea Catechins on Neurodegenerative Diseases.

Pervin M, Unno K, Ohishi T, Tanabe H, Miyoshi N, Nakamura Y

Molecules (Basel, Switzerland), 23(6), May, 2018 Peer-reviewed
Green tea extracts ameliorate high-fat diet–induced muscle atrophy in senescence-accelerated mouse prone-8 mice

Shintaro Onishi, Mayu Ishino, Hidefumi Kitazawa, Ai Yoto, Yuki Shimba, Yusuke Mochizuki, Keiko Unno, Shinichi Meguro, Ichiro Tokimitsu, Shinji Miura

PLoS ONE, 13(4) e0195753, Apr 1, 2018 Peer-reviewed
253

Blood-Brain Barrier Permeability of Green Tea Catechin Metabolites and their Neuritogenic Activity in Human Neuroblastoma SH-SY5Y Cells

Keiko Unno, Monira Pervin, Aimi Nakagawa, Kazuaki Iguchi, Aya Hara, Akiko Takagaki, Fumio Nanjo, Akira Minami, Yoriyuki Nakamura

MOLECULAR NUTRITION & FOOD RESEARCH, 61(12) 294, Dec, 2017 Peer-reviewed
310

Ingestion of green tea with lowered caffeine improves sleep quality of the elderly via suppression of stress

Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi, Yoriyuki Nakamura

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 61(3) 210-216, Nov, 2017 Peer-reviewed
Expression of a urokinase-type plasminogen activator during tumor growth leads to angiogenesis via galanin activation in tumor-bearing mice.

Yamamoto H, Okada R, Tanaka R, Unno K, Iguchi K

FEBS Open Bio, 7(11) 1784-1792, Oct, 2017 Peer-reviewed
SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions.

Ichiro Akiguchi, Mercè Pallàs, Herbert Budka, Haruhiko Akiyama, Masaki Ueno, Jingxian Han, Hideo Yagi, Tomohumi Nishikawa, Yoichi Chiba, Hiroshi Sugiyama …

Neuropathology : official journal of the Japanese Society of Neuropathology, 37(4) 293-305, Aug, 2017 Peer-reviewed
269

Reduced Stress and Improved Sleep Quality Caused by Green Tea Are Associated with a Reduced Caffeine Content

Keiko Unno, Shigenori Noda, Yohei Kawasaki, Hiroshi Yamada, Akio Morita, Kazuaki Iguchi, Yoriyuki Nakamura

NUTRIENTS, 9(7) E777, Jul, 2017 Peer-reviewed
171

Anti-stress Effect of Green Tea with Lowered Caffeine on Humans: A Pilot Study

Keiko Unno, Hiroshi Yamada, Kazuaki Iguchi, Hitoshi Ishida, Yasunori Iwao, Akio Morita, Yoriyuki Nakamura

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40(6) 902-909, Jun, 2017 Peer-reviewed

Misc.

Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice.

Satomi Shimoyoshi, Daisuke Takemoto, Yoshiko Ono, Yoshinori Kitagawa, Hiroshi Shibata, Susumu Tomono, Keiko Unno, Keiji Wakabayashi

Nutrients, 11(7), Jul 12, 2019
Stress-reducing effect of cookies containing matcha green tea: essential ratio among theanine, arginine, caffeine and epigallocatechin gallate

Keiko Unno, Daisuke Furushima, Shingo Hamamoto, Kazuaki Iguchi, Hiroshi Yamada, Akio Morita, Monira Pervin, Yoriyuki Nakamura

Heliyon, 5, e0163, May 1, 2019
抹茶の抗ストレス作用:成分組成の違いの影響

海野けい子, 浜本伸吾, 古島大資, 井口和明, 山田浩, 森田明雄, 中村順行

日本抗加齢医学会総会プログラム・抄録集, 18th 208-208, 2018
Aging Acceleration under Psychosocial Stress and Anti-stress Effect of Theanine

UNNO Keiko

35(4) 9-15, Nov 10, 2011
老化促進モデルマウスの学習記憶能における緑茶カテキンの効果（共著）

Proccedings of 2001 International Conference on O-Cha (tea) Culture and Scinece, Sessin III, 170-172, 2001
Effect of greeen tea catechins on learning and memory in sensescence-accelated mice (共著）

Proceedings of 2001 International Conference on OCha (tea) Culture and Science, Session III, 170-172, 2001
Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain

K Unno, H Asakura, Y Shibuya, M Kaiho, S Okada, N Oku

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 55(7) B329-B335, Jul, 2000
Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain

K Unno, H Asakura, Y Shibuya, M Kaiho, S Okada, N Oku

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 55(7) B329-B335, Jul, 2000
老齢ラット脳内における変性蛋白質とHsc70の増加

Molecular Chaperone & Heat Shock Response, p.249, 2000
老齢ラット脳内における構成的Hsp70（Hsc70)の発現レベルの増加

Journal of Gerontology: Biological Sciences, 55A, B329-B335, 2000
Increase in denatured proteins and the role of stress proteins in aged rat brain.

(4) 150, 2000
Increase in stress proteins and denatured proteins in aged rat brain.

34, 2000
Increase in Hsc70 and unstable proteins in aged rat brain(共著)

Molecular Chaperones & Heat Shock Response : Cold Spring Harbor Laboratory, Abstract 249, 2000
Increase in denatured proteins and the role of stress proteins in aged rat brain.

(4) 150, 2000
Increase in stress proteins and denatured proteins in aged rat brain.

34, 2000
Increase in Hsc70 and unstable proteins in aged rat brain(共著)

Molecular Chaperones & Heat Shock Response : Cold Spring Harbor Laboratory, Abstract 249, 2000
Use of deuterium oxide in the study of molecular chaperone

Keiko UNNO

Radioisotopes, 48(3) 239-240, 1999
Effect of chronic alcohol consumption on aging and the altered expression of stress protein in the brain.

94, 1999
Altered expression of Hsp70 in the aged rat brain hippocampus.

102, 1999
Altered expression of stress proteins in rat brain by aging and caloric restriction.

12, 1999

Books and Other Publications

茶の事典（大森正司・阿南豊正・伊勢村護・加藤みゆき・滝口明子・中村羊一郎編）: 老化制御

海野けい子 (Role: Joint author, pp. 388-390)

朝倉書店, 2017
Health Benefits of Green Tea, An Evidence-based Approach: Effects of Theanine and Other Ingredients of Tea on Stress and Aging

UNNO Keiko (Role: Joint author, pp.200-210)

CABI, 2017
Health Benefits of Green Tea, An Evidence-based Approach: Effects of Green Tea Catechins on Aging and Dementia

UNNO Keiko (Role: Joint author, pp.178-184)

CABI, 2017
Scientific Evidence for the Health Benefits of Green Tea：Effects on aging and dementia

UNNO Keiko (Role: Joint author, pp.136-146)

Japan Tea Central Public Interest Incorporated Association, 2015
〜Health Benefits of Green Tea〜 Navigation to Functional and Mechanistic Aspects 2014: Preventive Effects on Alzheimer Disease

UNNO Keiko (Role: Joint author, pp. 30-31)

2014
〜Health Benefits of Green Tea〜 Navigation to Functional and Mechanistic Aspects 2014: Anti-senescence effect

UNNO Keiko (Role: Joint author, pp. 28-29)

2014
茶の効能と応用開発：お茶による脳の老化予防（監修：伊勢村護）

シーエムシー出版, 2006 (ISBN: 4882315483)
Improvement in Brain Function and Oxidative Damage of Aged Senescence-accelerated Mice by Green Tea Catechins.

International Congress Series, 2004

Professional Memberships

Research Projects

Whether reduction of skeletal muscle function causes deterioration of cognitive function or depression symptoms

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

Miura Shinji, KAMEI YASUTOMI, ASAI AKIRA, UNNO KEIKO, YOSHIDA TAKUYA, SATO TOMOKI, SENOO NANAMI, ISHINO MAYU
社会心理的ストレスによる脳の老化に対するテアニン・アルギニンの予防効果に関する検討

奨学研究助成, （財）本庄国際奨学財団, Apr, 2017 - Mar, 2018

海野けい子
ストレスおよび糖尿病による脳の老化促進の機構解明と食品成分によるその予防

科学研究費補助金基盤研究（C）, 日本学術振興会, Apr, 2015 - Mar, 2017

海野けい子
茶カテキンの脳機能低下抑制作用における機構解明 -脳移行に関する検討-

奨学研究助成, 公益財団法人三島海雲記念財団, Apr, 2014 - Mar, 2015

海野けい子
脂質摂取量増加による脳の老化促進に関する検討—緑茶摂取による予防−

奨学研究助成, 花王健康科学研究会, Apr, 2013 - Mar, 2014

海野けい子
Study of dietary components that have anti-senescence and anti-stress effects in brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

UNNO Keiko, SUGIURA Minoru, KONISHI Tomokazu
Role of Stress Proteins in Protection from Cancer Metastasis and Aging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2000 - 2002

UNNO Keiko, OKU Naoto
Alteration of the Expression of Stress Protein by Aging and Alcohol in Brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1996 - 1997

UNNO Keiko, OKADA Shoji
加齢に伴う生体機能変化
老化に伴う脳機能および脳内蛋白質の変化
Effect of aging on brain function and protein denaturation
Effects of aging on the expression of stress proteins in Brain

Industrial Property Rights

特表2017-061438 脳神経細胞増殖促進剤

海野けい子, 原彩, 高垣晶子

Profile Information

Research Interests

Research Areas

Committee Memberships

Awards

Papers

Misc.

Books and Other Publications

Professional Memberships

Research Projects

Industrial Property Rights

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