2013年1月
Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice
EXPERIMENTAL PHYSIOLOGY
ダウンロード
回数 : 300
- 巻
- 98
- 号
- 1
- 開始ページ
- 290
- 終了ページ
- 303
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1113/expphysiol.2012.065532
- 出版者・発行元
- WILEY-BLACKWELL
The antistress effect of theanine (gamma-glutamylethylamide), an amino acid in tea, was investigated using mice that were psychosocially stressed from a conflict among male mice in conditions of confrontational housing. Two male mice were housed in the same cage separated by a partition to establish a territorial imperative. When the partition was removed, the mice were co-housed confrontationally. As a marker for the stress response, changes in the adrenal gland were studied in comparison to group-housed control mice (six mice in a cage). Significant adrenal hypertrophy was observed in mice during confrontational housing, which was developed within 24 h and persisted for at least 1 week. The size of cells in the zona fasciculata of the adrenal gland, from which glucocorticoid is mainly secreted, increased (similar to 1.11-fold) in mice during confrontational housing, which was accompanied by a flattened diurnal rhythm of corticosterone and ACTH in blood. The ingestion of theanine (>5 mu g ml(-1)) prior to confrontational housing significantly suppressed adrenal hypertrophy. An antidepressant, paroxetin, suppressed adrenal hypertrophy in a similar manner in mice during confrontational housing. In mice that ingested theanine, behavioural depression was also suppressed, and a diurnal rhythm of corticosterone and ACTH was observed, even in mice that were undergoing confrontational housing. Furthermore, the daily dose of theanine (40 mu g ml(-1)) blocked the counteracting effects of caffeine (30 mu g ml(-1)) and catechin (200 mu g ml(-1)). The present study demonstrated that theanine prevents and relieves psychosocial stress through the modulation of hypothalamic-pituitary-adrenal axis activity.
- リンク情報
- ID情報
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- DOI : 10.1113/expphysiol.2012.065532
- ISSN : 0958-0670
- Web of Science ID : WOS:000313255900030