MISC

2008年2月

Active immunization against macrophage migration inhibitory factor using a novel DNA vaccine prevents ovariectomy-induced bone loss in mice

VACCINE
  • Shin Onodera
  • ,
  • Shigeki Oshima
  • ,
  • Jun Nishihira
  • ,
  • Kazunori Yasuda
  • ,
  • Harukazu Tohyama
  • ,
  • Kazuharu Irie
  • ,
  • Yoshikazu Koyama

26
6
開始ページ
829
終了ページ
836
記述言語
英語
掲載種別
DOI
10.1016/j.vaccine.2007.11.066
出版者・発行元
ELSEVIER SCI LTD

Previous studies have demonstrated that mice deficient in the macrophage migration inhibitory factor (MIF) gene are protected from ovariectomy (OVX)-induced bone loss. We developed a novel MIF-deoxyribonucleic acid (DNA) vaccine by introducing oligonucleotides encoding a helper T epitope into the cDNA sequence of murine MIF Mice given the MIF-DNA vaccine produced high titers of autoantibody against MIF, and were protected from OVX-induced bone loss. Our results further support the hypothesis that MIF is involved in the pathomechanism of OVX-induced bone loss, and also show that active immunization against MIF using a DNA vaccine may be useful for the prophylactic treatment of postmenopausal osteoporosis. (c) 2007 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.vaccine.2007.11.066
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000253309700011&DestApp=WOS_CPL

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