論文

査読有り
2015年4月

Brain-bladder control network: The unsolved 21st century urological mystery

INTERNATIONAL JOURNAL OF UROLOGY
  • Takeya Kitta
  • ,
  • Takahiko Mitsui
  • ,
  • Yukiko Kanno
  • ,
  • Hiroki Chiba
  • ,
  • Kimihiko Moriya
  • ,
  • Nobuo Shinohara

22
4
開始ページ
342
終了ページ
348
記述言語
英語
掲載種別
DOI
10.1111/iju.12721
出版者・発行元
WILEY-BLACKWELL

A review of functional brain imaging studies of bladder control in participants with normal control and pathological conditions. In the normal condition, bladder and urethral afferents received in the periaqueductal gray relay the information to the insula, the anterior cingulate cortex and the prefrontal cortex. During the storage phase, these superior regions control the pontine micturition center to inhibit voiding. In overactive bladder patients, brain responses are different. Cortical responses become exaggerated, especially in the anterior cingulate cortex and the supplementary motor area. That is what presumably evokes the urgency. The supplementary motor area is activated during contraction of the pelvic floor muscles, and provides protection against incontinence. We believe that functional brain imaging studies are promising not only for the understanding of bladder dysfunction, but also as an aid to the development of therapeutic options for chronic disorders.

Web of Science ® 被引用回数 : 22

リンク情報
DOI
https://doi.org/10.1111/iju.12721
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25693685
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000352228500003&DestApp=WOS_CPL

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