論文

査読有り 国際誌
2015年1月15日

Concurrent occurrence of renal cell carcinoma with rhabdoid features in a married couple: a case report.

BMC research notes
  • Ryuji Matsumoto
  • ,
  • Nobuo Shinohara
  • ,
  • Kanako C-Hatanaka
  • ,
  • Naoto Kuroda
  • ,
  • Kunihiko Tsuchiya
  • ,
  • Satoru Maruyama
  • ,
  • Takashige Abe
  • ,
  • Katsuya Nonomura

8
開始ページ
3
終了ページ
3
記述言語
英語
掲載種別
DOI
10.1186/s13104-014-0957-z

BACKGROUND: Renal cell carcinoma (RCC) with rhabdoid features is a rare histology and exhibits clinically aggressive behavior. We report a case of a married couple in whom RCC with rhabdoid features concurrently occurred. The rarity of this event suggests that environmental factors may contribute to the etiology of RCC with rhabdoid features. CASE PRESENTATION: A 76-year-old Japanese woman was diagnosed with a hypervascular mass in the right kidney and tumor thrombus extending into the right atrium by enhanced computed tomography (CT). She underwent radical nephrectomy and tumor thrombectomy following systemic therapy with the tyrosine kinase inhibitor sunitinib. The histological evaluation denoted clear cell RCC with rhabdoid features. The patient died of cancer 12 months postoperatively. A 76-year-old man, her husband, presented with gross hematuria 2 weeks after his wife had undergone surgery. He had a long history of asbestos exposure. An abdominal CT scan revealed a hypervascular mass in the right kidney and tumor thrombus extending into the inferior vena cava. He also underwent radical nephrectomy and tumor thrombectomy. The histological evaluation also showed clear cell RCC with rhabdoid features. Bone metastasis occurred 12 months postoperatively, but he died of an unrelated cause 18 months after surgery. CONCLUSION: Concurrent occurrence of RCC with rhabdoid features may not to be coincidental. Although further studies are warranted, asbestos exposure may contribute to the etiology of clear cell RCC with rhabdoid features.

リンク情報
DOI
https://doi.org/10.1186/s13104-014-0957-z
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25588411
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302605

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