論文

査読有り
2015年7月

Should inclusion criteria for active surveillance for low-risk prostate cancer be more stringent? From an interim analysis of PRIAS-JAPAN

WORLD JOURNAL OF UROLOGY
  • Mikio Sugimoto
  • ,
  • Hiromi Hirama
  • ,
  • Akito Yamaguchi
  • ,
  • Hirofumi Koga
  • ,
  • Katsuyoshi Hashine
  • ,
  • Iku Ninomiya
  • ,
  • Nobuo Shinohara
  • ,
  • Satoru Maruyama
  • ,
  • Shin Egawa
  • ,
  • Hiroshi Sasaki
  • ,
  • Yoshiyuki Kakehi

33
7
開始ページ
981
終了ページ
987
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00345-014-1453-8
出版者・発行元
SPRINGER

To define clinical and pathological factors predicting reclassification at the time of 1-year repeat biopsy (re-Bx) based on a Japanese cohort forming part of the Prostate Research International: Active Surveillance (PRIAS) study.
The inclusion criteria for the PRIAS study are as follows: clinical stage T1c/T2, PSA a parts per thousand currency sign 10 ng/ml, PSA density (PSAD) < 0.2 ng/ml per milliliter, one or two positive biopsy cores, and Gleason score (GS) a parts per thousand currency sign 6 at initial diagnostic biopsy. Baseline clinical characteristics and prostate-specific antigen doubling time (PSADT) at the time of re-Bx were analyzed via multivariate logistic regression with respect to reclassification and 'no cancer' status on the 1-year re-Bx.
A total of 386 patients were enrolled in PRIAS-JAPAN by the end of 2013. Of these, 216 underwent re-Bx at 1 year. A total of 73 patients (33.8 %) were reclassified, whereas 74 (34.3 %) had no cancer. Older age, a higher PSAD, a higher positive core rate, and a shorter PSADT were significant predictors of reclassification. The positive core rate was the predictor common to reclassification, no cancer, and high GS, upon re-Bx.
An interim analysis of a Japanese AS cohort participating in PRIAS revealed that the positive core rate was strongly associated with reclassification at the 1-year re-Bx. However, although amendment of the PRIAS inclusion criteria to incorporate a positive core might reduce any concern about underestimation, this would also reduce the number of patients undergoing AS.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1007/s00345-014-1453-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25428792
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000356814700011&DestApp=WOS_CPL

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