論文

査読有り
2014年1月

Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer

JAPANESE JOURNAL OF CLINICAL ONCOLOGY
  • Kentaro Nishioka
  • ,
  • Shinichi Shimizu
  • ,
  • Nobuo Shinohara
  • ,
  • Yoichi M. Ito
  • ,
  • Takashige Abe
  • ,
  • Satoru Maruyama
  • ,
  • Rumiko Kinoshita
  • ,
  • Keiichi Harada
  • ,
  • Noboru Nishikawa
  • ,
  • Naoki Miyamoto
  • ,
  • Rikiya Onimaru
  • ,
  • Hiroki Shirato

44
1
開始ページ
28
終了ページ
35
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jjco/hyt182
出版者・発行元
OXFORD UNIV PRESS

The real-time tumor-tracking radiotherapy system with fiducial markers has the advantage that it can be used to verify the localization of the markers during radiation delivery in real-time. We conducted a prospective Phase II study of image-guided local-boost radiotherapy for locally advanced bladder cancer using a real-time tumor-tracking radiotherapy system for positioning, and here we report the results regarding the safety and efficacy of the technique.
Twenty patients with a T2-T4N0M0 urothelial carcinoma of the bladder who were clinically inoperable or refused surgery were enrolled. Transurethral tumor resection and 40 Gy irradiation to the whole bladder was followed by the transurethral endoscopic implantation of gold markers in the bladder wall around the primary tumor. A boost of 25 Gy in 10 fractions was made to the primary tumor while maintaining the displacement from the planned position at less than 2 mm during radiation delivery using a real-time tumor-tracking radiotherapy system. The toxicity, local control and survival were evaluated.
Among the 20 patients, 14 were treated with concurrent chemoradiotherapy. The median follow-up period was 55.5 months. Urethral and bowel late toxicity (Grade 3) were each observed in one patient. The local-control rate, overall survival and cause-specific survival with the native bladder after 5 years were 64, 61 and 65.
Image-guided local-boost radiotherapy using a real-time tumor-tracking radiotherapy system can be safely accomplished, and the clinical outcome is encouraging. A larger prospective multi-institutional study is warranted for more precise evaluations of the technological efficacy and patients quality of life.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1093/jjco/hyt182
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24302759
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000329251500006&DestApp=WOS_CPL

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