論文

査読有り
2014年4月

Outcome of Metastasectomy for Urothelial Carcinoma: A Multi-Institutional Retrospective Study in Japan

JOURNAL OF UROLOGY
  • Takashige Abe
  • ,
  • Hiroshi Kitamura
  • ,
  • Wataru Obara
  • ,
  • Nagahide Matsumura
  • ,
  • Taiji Tsukamoto
  • ,
  • Tomoaki Fujioka
  • ,
  • Isao Hara
  • ,
  • Sachiyo Murai
  • ,
  • Nobuo Shinohara
  • ,
  • Katsuya Nonomura

191
4
開始ページ
932
終了ページ
936
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.juro.2013.11.004
出版者・発行元
ELSEVIER SCIENCE INC

Purpose: We determined prognostic factors associated with prolonged survival after metastasectomy for urothelial carcinoma.
Materials and Methods: A total of 42 patients who underwent resection of urothelial carcinoma metastases with curative intent at 4 Japanese university hospitals were included in analysis. Of the patients 41 of 42 underwent systemic chemotherapy before and/or after metastasectomy. Overall survival was analyzed using the Kaplan-Meier method. The relationship between clinical characteristics and survival was analyzed using the log rank test.
Results: Metastasectomy included lymph node dissection in 20 cases, pulmonary resection in 12, pelvic exenteration in 3, resection of local recurrence in 2, resection of subcutaneous metastasis in 2, liver resection in 1 and other in 2. Median overall survival was 29 months (IQR 19-80) from the initiation of treatment for metastases and 26 months (IQR 11-90) from metastasectomy. The overall 5-year survival rate after metastasectomy was 31%. On univariate analysis patients treated with metastasectomy for a solitary lung or solitary lymph node metastasis had significantly longer survival than the others who underwent metastasectomy (81 vs 19 months, log rank test p = 0.0296).
Conclusions: Long-term cancer control could be achieved in a subgroup of patients who undergo metastasectomy, especially those with a solitary lung or solitary lymph node metastasis.

Web of Science ® 被引用回数 : 39

リンク情報
DOI
https://doi.org/10.1016/j.juro.2013.11.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24211599
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000334763100013&DestApp=WOS_CPL

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