論文

査読有り
2012年5月

CXCR7: A novel tumor endothelial marker in renal cell carcinoma

PATHOLOGY INTERNATIONAL
  • Nako Maishi
  • ,
  • Noritaka Ohga
  • ,
  • Yasuhiro Hida
  • ,
  • Kosuke Akiyama
  • ,
  • Kazuko Kitayama
  • ,
  • Takahiro Osawa
  • ,
  • Yuichiro Onodera
  • ,
  • Nobuo Shinohara
  • ,
  • Katsuya Nonomura
  • ,
  • Masanobu Shindoh
  • ,
  • Kyoko Hida

62
5
開始ページ
309
終了ページ
317
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1440-1827.2012.02792.x
出版者・発行元
WILEY-BLACKWELL

Tumor angiogenesis is necessary for progression and metastasis of solid tumor. Tumor blood vessels are morphologically different from their normal counterparts. In this study, we isolated tumor endothelial cells (TECs) and revealed their abnormalities. We have compared the gene expression profiles of TECs and normal endothelial cells (NECs) by microarray analysis and found that several genes were upregulated in TECs. Expression of the chemokine receptor CXCR7 mRNA was higher in TECs than in NECs. However, information regarding the expression of CXCR7 in the tumor vessels of renal cell carcinoma is limited. CXCR7 and its ligand CXCL12 have been implicated in tumor cell survival. In this study, the expression of CXCR7 in the tumor vessels of renal cell carcinoma (RCC) was investigated. Real-time PCR revealed higher expression level of CXCR7 in cultured TECs than in cultured NECs. Furthermore, similar to mouse TECs, immunostaining revealed strong expression of CXCR7 in vivo in human tumor vessels. These findings suggest that CXCR7 is a novel TEC marker and a target for antiangiogenic therapy for RCC.

Web of Science ® 被引用回数 : 47

リンク情報
DOI
https://doi.org/10.1111/j.1440-1827.2012.02792.x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22524658
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000303200600003&DestApp=WOS_CPL

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