論文

査読有り
2017年8月

miR-145 promoted anoikis resistance in tumor endothelial cells

JOURNAL OF BIOCHEMISTRY
  • Kyoko Hida
  • ,
  • Taisuke Kawamoto
  • ,
  • Nako Maishi
  • ,
  • Masahiro Morimoto
  • ,
  • Kosuke Akiyama
  • ,
  • Noritaka Ohga
  • ,
  • Masanobu Shindoh
  • ,
  • Nobuo Shinohara
  • ,
  • Yasuhiro Hida

162
2
開始ページ
81
終了ページ
84
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/jb/mvx033
出版者・発行元
OXFORD UNIV PRESS

Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

Web of Science ® 被引用回数 : 2

リンク情報
DOI
https://doi.org/10.1093/jb/mvx033
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28510655
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000407157900003&DestApp=WOS_CPL

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