論文

査読有り
2017年4月

Radical prostatectomy restores detrusor contraction pattern according to pressure flow parameters

INTERNATIONAL JOURNAL OF UROLOGY
  • Takeya Kitta
  • ,
  • Yukiko Kanno
  • ,
  • Hiroki Chiba
  • ,
  • Kimihiko Moriya
  • ,
  • Satoru Maruyama
  • ,
  • Takashige Abe
  • ,
  • Nobuo Shinohara

24
4
開始ページ
301
終了ページ
307
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/iju.13295
出版者・発行元
WILEY

ObjectivesPressure flow studies are regarded as the gold standard for evaluating both bladder outlet obstruction and detrusor contractility, but none of the current methods for evaluating bladder contraction patterns are well validated. Impaired bladder contraction results in a lower peak Watts factor and poorly sustained detrusor contractions. From this viewpoint, the maximum Watts factor and its pattern should be considered separately. To examine detrusor contraction pattern in patients after radical prostatectomy by using multiple parameters.
MethodsA total of 37 patients with clinically localized prostate cancer underwent both pre- and post-radical prostatectomy urodynamic evaluations. The examined urodynamic parameters included the maximum flow rate, post-void residual volume, detrusor pressure at maximum flow, maximum Watts factor and relative volume (maximum Watts factor). Some parameters were defined from the Watts factor curve throughout micturition. Relative volume (maximum Watts factor) was the relative bladder volume at the maximum Watts factor. A normal detrusor contractility pattern involves an increase in Watts factor at the initiation followed by further gradual increases until the end of micturition.
ResultsMaximum flow rate increased significantly after radical prostatectomy (pre: 13.06.5, post: 17.3 +/- 7.7mL/min; P<0.01), whereas detrusor pressure at maximum flow and post-void residual volume decreased significantly (pre: 49.6 +/- 21.6 and 31.4 +/- 18.2cmH(2)O; post: 48.6 +/- 66.1 and 10.1 +/- 28.5mL; P<0.05). Maximum Watts factor did not change significantly after radical prostatectomy (pre: 10.5 +/- 3.1W/m(2), post: 11.0 +/- 3.2W/m(2)), but relative volume (maximum Watts factor) decreased significantly (pre: 0.48 +/- 0.3, post: 0.20 +/- 0.20; P<0.001). Maximum Watts factor represents the maximum power of bladder contraction at a particular point in time, whereas relative volume (maximum Watts factor) can be used to detect changes in detrusor contraction pattern.
ConclusionsEvaluation of relative volume (maximum Watts factor) confirms that radical prostatectomy restores the normal detrusor contractility pattern in prostate cancer patients.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1111/iju.13295
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28122392
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399312000012&DestApp=WOS_CPL

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