論文

査読有り
2016年12月

Tumor endothelial cells express high pentraxin 3 levels

PATHOLOGY INTERNATIONAL
  • Kyoko Hida
  • ,
  • Nako Maishi
  • ,
  • Taisuke Kawamoto
  • ,
  • Kosuke Akiyama
  • ,
  • Noritaka Ohga
  • ,
  • Yasuhiro Hida
  • ,
  • Kenji Yamada
  • ,
  • Takayuki Hojo
  • ,
  • Hiroshi Kikuchi
  • ,
  • Masumi Sato
  • ,
  • Chisaho Torii
  • ,
  • Nobuo Shinohara
  • ,
  • Masanobu Shindoh

66
12
開始ページ
687
終了ページ
694
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/pin.12474
出版者・発行元
WILEY-BLACKWELL

It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer-related inflammation, but we found no reports on its expression and function in tumor blood vessels. Here we showed that PTX3 is expressed inmouse and human tumor blood vessels based on immunohistochemical analysis. We found that PTX3 is upregulated in primary mouse and human tumor endothelial cells compared to normal endothelial cells. We also showed that PTX3 plays an important role in the proliferation of the tumor endothelial cells. These results suggest that PTX3 is an important target for antiangiogenic therapy.

Web of Science ® 被引用回数 : 3

リンク情報
DOI
https://doi.org/10.1111/pin.12474
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27862647
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000389152600005&DestApp=WOS_CPL

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