論文

査読有り
2016年9月

Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children's Health

ENVIRONMENT INTERNATIONAL
  • Sachiko Itoh
  • ,
  • Atsuko Araki
  • ,
  • Takahiko Mitsui
  • ,
  • Chihiro Miyashita
  • ,
  • Houman Goudarzi
  • ,
  • Seiko Sasaki
  • ,
  • Kazutoshi Cho
  • ,
  • Hiroyuki Nakazawa
  • ,
  • Yusuke Iwasaki
  • ,
  • Nobuo Shinohara
  • ,
  • Katsuya Nonomura
  • ,
  • Reiko Kishi

94
開始ページ
51
終了ページ
59
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.envint.2016.05.011
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Background: Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive function in animals and humans. Although PFASs can cross the human placental barrier, few studies evaluated the effects of prenatal PFAS exposure on the fetus' reproductive hormones.
Objective: To explore the associations of prenatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) with cord blood reproductive hormones.
Methods: In the prospective birth cohort (Sapporo cohort of the Hokkaido study), we included 189 mother-infant pairs recruited in 2002-2005 with both prenatal maternal and cord blood samples. PFOS and PFOA levels in maternal blood after the second trimester were measured via liquid chromatography-tandem mass spectrometry. We also measured cord blood levels of the fetuses' reproductive hormones, including estradiol (E2), total testosterone (T), progesterone (P4), inhibin B, insulin-like factor 3, steroid hormone binding globulin, follicle-stimulating hormone, and luteinizing hormone, and prolactin (PRL).
Results: The median PFOS and PFOA levels in maternal serum were 5.2 ng/mL and 1.4 ng/mL, respectively. In the fully adjusted linear regression analyses of the male infants, maternal PFOS levels were significantly associated with E2 and positively, and T/E2, P4, and inhibin B inversely; PFOA levels were positively associated with inhibin B levels. Among the female infants, there were significant inverse associations between PFOS levels and P4 and PRL levels, although there were no significant associations between PFOA levels and the female infants' reproductive hormone levels.
Conclusions: These results suggest that the fetal synthesis and secretion of reproductive hormones may be affected by in utero exposure to measurable levels of PFOS and PFOA. (C) 2016 Elsevier Ltd. All rights reserved.

Web of Science ® 被引用回数 : 46

リンク情報
DOI
https://doi.org/10.1016/j.envint.2016.05.011
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27209000
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382339000006&DestApp=WOS_CPL

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