論文

査読有り
2016年9月

Factors affecting post-pubertal penile size in patients with hypospadias

WORLD JOURNAL OF UROLOGY
  • Kimihiko Moriya
  • ,
  • Michiko Nakamura
  • ,
  • Yoko Nishimura
  • ,
  • Takeya Kitta
  • ,
  • Yukiko Kanno
  • ,
  • Hiroki Chiba
  • ,
  • Masafumi Kon
  • ,
  • Nobuo Shinohara

34
9
開始ページ
1317
終了ページ
1321
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s00345-016-1763-0
出版者・発行元
SPRINGER

To evaluate actual post-pubertal penile size and factors affecting it in hypospadias patients, we retrospectively reviewed medical charts.
Hypospadias patients whose external genitalia were categorized into Tanner stage 5, and whose stretched penile length was evaluated at 15 years old or older from April 2008 to April 2015, were enrolled in the present study. Stretched penile length was measured by a single examiner. Actual post-pubertal stretched penile length and factors affecting the post-pubertal stretched penile length were estimated. Statistical analysis was performed using Mann-Whitney U test and univariate and multivariate linear regression models for the determination of independent factors.
Thirty patients met the inclusion criteria. Median age at evaluation was 17.2 years. Thirteen and 17 had mild and severe hypospadias, respectively. Endocrinological abnormality was identified in 5. Multivariate analysis showed that the severity of hypospadias and endocrinological abnormality were significant factors affecting stretched penile length. Stretched penile length in 25 patients without endocrinological abnormality was significantly longer than that in those with endocrinological abnormality (p = 0.036). Among patients without endocrinological abnormality, stretched penile length in 13 with severe hypospadias was significantly shorter than that in 12 with mild hypospadias (p = 0.004).
While the severity of hypospadias and endocrinological abnormality at post-pubertal evaluation were factors affecting post-pubertal penile size, stretched penile length in patients with severe hypospadias was shorter even in cases without endocrinological abnormality. These results suggest that severe hypospadias is not only a disorder of urethral development, but also a disorder of penile development.

Web of Science ® 被引用回数 : 1

リンク情報
DOI
https://doi.org/10.1007/s00345-016-1763-0
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26792579
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000382175100018&DestApp=WOS_CPL

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