2013年
Dynamics of Living Cells Measured by Scanning Probe Microscopy
表面科学
- ,
- 巻
- 34
- 号
- 9
- 開始ページ
- 500-504 (J-STAGE)
- 終了ページ
- 504
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1380/jsssj.34.500
- 出版者・発行元
- The Surface Science Society of Japan
Atomic force microscope (AFM) has advantages in the measurement of mechanical properties of soft materials. Here, we introduced applications of AFM to elucidate a single cell mechanics and multi-cellular dynamics. Comparison of elasticity map of fibroblasts with distribution of intracellular cytoskeletal fibers showed correspondence of high elasticity regions andactin fiber distributions. A representative morphology of cellular membrane ruffling was clearly observed and elasticity of the ruffling regions was higher than that of the outside of the ruffling regions. Elasticity map of epithelial cells showed cell-cell contact point is high elasticity. Cellular elasticity measurements by AFM will be applied to medical usages and some modifications of AFM will open a new door to study dynamics of soft materials.
- リンク情報
- ID情報
-
- DOI : 10.1380/jsssj.34.500
- ISSN : 0388-5321
- J-Global ID : 201402246390290374
- CiNii Articles ID : 10031195952
- CiNii Books ID : AN00334149