論文

査読有り
2017年4月

Toward the Atomic-Level Mass Analysis of Biomolecules by the Scanning Atom Probe

MICROSCOPY AND MICROANALYSIS
  • Osamu Nishikawa
  • ,
  • Masahiro Taniguchi

23
2
開始ページ
336
終了ページ
339
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1017/S1431927616012551
出版者・発行元
CAMBRIDGE UNIV PRESS

In 1994, a new type of atom probe instrument, named the scanning atom probe (SAP), was proposed. The unique feature of the SAP is the introduction of a small extraction electrode, which scans over a specimen surface and confines the high field, required for field evaporation of surface atoms in a small space, between the specimen and the electrode. Thus, the SAP does not require a sharp specimen tip. This indicates that the SAP can mass analyze the specimens which are difficult to form in a sharp tip, such as organic materials and biomolecules. Clean single wall carbon nanotubes (CNT), made by high-pressure carbon monoxide process are found to be the best substrates for biomolecules. Various amino acids and dipeptide biomolecules were successfully mass analyzed, revealing characteristic clusters formed by strongly bound atoms in the specimens. The mass analysis indicates that SAP analysis of biomolecules is not only qualitative, but also quantitative.

リンク情報
DOI
https://doi.org/10.1017/S1431927616012551
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000405595600017&DestApp=WOS_CPL
ID情報
  • DOI : 10.1017/S1431927616012551
  • ISSN : 1431-9276
  • eISSN : 1435-8115
  • Web of Science ID : WOS:000405595600017

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