MISC

2004年8月

A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Kadota, I
  • ,
  • YQ Hu
  • ,
  • GK Packard
  • ,
  • SD Rychnovsky

101
33
開始ページ
11992
終了ページ
11995
記述言語
英語
掲載種別
DOI
10.1073/pnas.0401552101
出版者・発行元
NATL ACAD SCIENCES

Polyene macrolide antibiotics are naturally occurring antifungal agents. Members of this class include amphotericin B, which has been used widely to treat systemic fungal infections. A general synthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides. Cyanohydrin acetonide alkylations were used to assemble the carbon skeleton, and a simple modification of the strategy allowed an advanced intermediate to be converted to either the candidin polyol or the nystatin polyol. The candidin polyol was further elaborated to a protected candidin aglycone. This strategy will be applicable to other members of the polyene macrolide natural products.

Web of Science ® 被引用回数 : 20

リンク情報
DOI
https://doi.org/10.1073/pnas.0401552101
CiNii Articles
http://ci.nii.ac.jp/naid/80016853861
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/15192147
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223410100016&DestApp=WOS_CPL

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