2004年8月
A unified approach to polyene macrolides: Synthesis of candidin and nystatin polyols
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- 巻
- 101
- 号
- 33
- 開始ページ
- 11992
- 終了ページ
- 11995
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1073/pnas.0401552101
- 出版者・発行元
- NATL ACAD SCIENCES
Polyene macrolide antibiotics are naturally occurring antifungal agents. Members of this class include amphotericin B, which has been used widely to treat systemic fungal infections. A general synthetic strategy has been devised to prepare polyol chains associated with the polyene macrolides. Cyanohydrin acetonide alkylations were used to assemble the carbon skeleton, and a simple modification of the strategy allowed an advanced intermediate to be converted to either the candidin polyol or the nystatin polyol. The candidin polyol was further elaborated to a protected candidin aglycone. This strategy will be applicable to other members of the polyene macrolide natural products.
- リンク情報
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- DOI
- https://doi.org/10.1073/pnas.0401552101
- CiNii Articles
- http://ci.nii.ac.jp/naid/80016853861
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/15192147
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000223410100016&DestApp=WOS_CPL
- ID情報
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- DOI : 10.1073/pnas.0401552101
- ISSN : 0027-8424
- CiNii Articles ID : 80016853861
- PubMed ID : 15192147
- Web of Science ID : WOS:000223410100016