1993年9月
DECREASED TERATOGEN SUSCEPTIBILITY IN MOUSE FETUSES OBTAINED FROM DELAYED MATING
REPRODUCTIVE TOXICOLOGY
- ,
- 巻
- 7
- 号
- 5
- 開始ページ
- 423
- 終了ページ
- 427
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/0890-6238(93)90086-M
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We examined whether the susceptibility of fetuses to a teratogen differs between fetuses from delayed mating and those from normal mating. Mitomycin-C (MMC; 2.5 mg/kg or 5.0 mg/kg) was administered to pregnant mice intraperitoneally on day 10 of gestation after either normal or delayed mating (6 h). The incidence of MMC-induced malformations in fetuses from delayed mating was significantly lower than in those from the normal mating group when the treatment time was adjusted to be at the same critical period according to the ''catch-up'' phenomenon of developmental progression in the delayed mating group.
- リンク情報
- ID情報
-
- DOI : 10.1016/0890-6238(93)90086-M
- ISSN : 0890-6238
- PubMed ID : 8274817
- Web of Science ID : WOS:A1993MC73900003