2001年1月
Induction of micronuclei formation in preimplantation mouse embryos after maternal treatment with 2-bromopropane
REPRODUCTIVE TOXICOLOGY
- ,
- ,
- 巻
- 15
- 号
- 1
- 開始ページ
- 81
- 終了ページ
- 85
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/S0890-6238(00)00112-X
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
We examined effects of 2-bromopropane (2-BP), a chlorofluorocarbon replacement, on mouse embryonic mutagenicity. 2-BP was administered to pregnant mice intraperitoneally (i.p.) (300, 600, 900, and 1800 mg/kg) during the early preimplantation period. On day 3 of gestation, micronuclei (MN) frequency and embryo cell number were determined. 2-BP induced a dose-related significant increase in MN frequency and a treatment-related decrease in embryo cell number. Furthermore, the cell numbers were significantly smaller in the MN-positive embryos by two-way ANOVA taking it into account an interactive effect between 2-BP dose and the presence or absence of MN. A simultaneous decrease in cell number and increase in MN frequency may reflect an embryonic developmental disadvantage resulting from maternal treatment with 2-BP. Further study is needed to establish how 2-BP contributes to postimplantation embryonic development. (C) 2001 Elsevier Science Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/S0890-6238(00)00112-X
- ISSN : 0890-6238
- Web of Science ID : WOS:000166372500011