Kiyoko Fukami - My portal

Profile Information

Affiliation: Professor, School of Life Science, Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences

Degree: (BLANK)

J-GLOBAL ID: 200901069039683880
researchmap Member ID: 1000161264

External link: http://toyaku-ls-genome.com

Research Interests

Research Areas

Research History

Apr, 2003 - Present

School of Life Science, Tokyo University of Pharmacy and Life Sciences
Apr, 2012 - Mar, 2016

School of Life Science, Tokyo University of Pharmacy and Life Sciences
2002 - 2003

The Institute of Medical Science, The University of Tokyo
1999 - 2002

The Institute of Medical Science, The University of Tokyo
1992 - 2002

Department of Biochemistry, Institute of Medical
2002

- Professor, Laboratory of Genome and Biosignal
1992 - 1999

The Institute of Medical Science, The University of Tokyo
1985 - 1992

東京都老人総合研究所薬理(現生体情報)研究室助手
1985 - 1992

Research Associate Department of Pharmacology,
1978 - 1982

慶応大学医学部薬局試験研究室
1978 - 1982

Department of Pharmaceutical Experimental Lab.
and Life Science
School of Life Science, Tokyo University of Pharmacy
Science, The University of Tokyo
Tokyo Metropolitan Institute of Gerontology
Faculty of Medicine, Keio University

Education

Committee Memberships

Awards

Papers

Cell surface CD63 increased by up-regulated polylactosamine modification sensitizes human melanoma cells to the BRAF inhibitor PLX4032

Kohya Kudo, Atsuko Yoneda, Daiki Sakiyama, Kai Kojima, Takeki Miyaji, Miku Yamazaki, Saori Yaita, Takuya Hyodo, Reiko Satow, Kiyoko Fukami

FASEB J., 33 3851-3869, 2019 Peer-reviewed
Phospholipase C delta 1 regulates p38 MAPK activity and skin barrier integrity

Kaori Kanemaru, Yoshikazu Nakamura, Kengo Totoki, Takatsugu Fukuyama, Madoka Shoji, Hisae Kaneko, Kanako Shiratori, Atsuko Yoneda, Takafumi Inoue, Yoichiro Iwakura …

CELL DEATH AND DIFFERENTIATION, 24(6) 1079-1090, Jun, 2017 Peer-reviewed
ZIC5 Drives Melanoma Aggressiveness by PDGFD-Mediated Activation of FAK and STAT3

Reiko Satow, Tomomi Nakamura, Chiaki Kato, Miku Endo, Mana Tamura, Ryosuke Batori, Shiori Tomura, Yumi Murayama, Kiyoko Fukami

CANCER RESEARCH, 77(2) 366-377, Jan, 2017 Peer-reviewed
Phospholipase C delta 1 induces E-cadherin expression and suppresses malignancy in colorectal cancer cells

Reiko Satow, Tamaki Hirano, Ryosuke Batori, Tomomi Nakamura, Yumi Murayama, Kiyoko Fukami

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 111(37) 13505-13510, Sep, 2014 Peer-reviewed
Simultaneous loss of phospholipase C delta 1 and phospholipase C delta 3 causes cardiomyocyte apoptosis and cardiomyopathy

Y. Nakamura, K. Kanemaru, R. Kojima, Y. Hashimoto, T. Marunouchi, N. Oka, T. Ogura, K. Tanonaka, K. Fukami

CELL DEATH & DISEASE, 5 e1215, May, 2014 Peer-reviewed
Identification of novel small compounds that restore E-cadherin expression and inhibit tumor cell motility and invasiveness

Tamaki Hirano, Reiko Satow, Asami Kato, Mana Tamura, Yumi Murayama, Hideyuki Saya, Hirotatsu Kojima, Tetsuo Nagano, Takayoshi Okabe, Kiyoko Fukami

BIOCHEMICAL PHARMACOLOGY, 86(10) 1419-1429, Nov, 2013 Peer-reviewed
Epidermal phospholipase C delta 1 regulates granulocyte counts and systemic interleukin-17 levels in mice

Kaori Kanemaru, Yoshikazu Nakamura, Kojiro Sato, Ryota Kojima, Saori Takahashi, Mami Yamaguchi, Manabu Ichinohe, Hiroshi Kiyonari, Go Shioi, Kenji Kabashima …

NATURE COMMUNICATIONS, 3 963, Jul, 2012 Peer-reviewed
Genetic Defect in Phospholipase C delta 1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis

Masayuki Hirata, Mutsumi Suzuki, Rika Ishii, Reiko Satow, Takafumi Uchida, Tomoya Kitazumi, Tsutomu Sasaki, Tadahiro Kitamura, Hideki Yamaguchi, Yoshikazu Nakamura …

DIABETES, 60(7) 1926-1937, Jul, 2011 Peer-reviewed

Misc.

Epidermal phospholipase C delta 1 regulates granulocyte counts and systemic interleukin-17 levels in mice

Kaori Kanemaru, Yoshikazu Nakamura, Kojiro Sato, Ryota Kojima, Saori Takahashi, Mami Yamaguchi, Manabu Ichinohe, Hiroshi Kiyonari, Go Shioi, Kenji Kabashima …

NATURE COMMUNICATIONS, 3 963, Jul, 2012 Peer-reviewed
Genetic Defect in Phospholipase C delta 1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis

Masayuki Hirata, Mutsumi Suzuki, Rika Ishii, Reiko Satow, Takafumi Uchida, Tomoya Kitazumi, Tsutomu Sasaki, Tadahiro Kitamura, Hideki Yamaguchi, Yoshikazu Nakamura …

DIABETES, 60(7) 1926-1937, Jul, 2011
Phosphoinositide 3-kinase signaling pathway mediated by p110 alpha regulates invadopodia formation

Hideki Yamaguchi, Shuhei Yoshida, Emi Muroi, Nachi Yoshida, Masahiro Kawamura, Zen Kouchi, Yoshikazu Nakamura, Ryuichi Sakai, Kiyoko Fukami

JOURNAL OF CELL BIOLOGY, 193(7) 1275-1288, Jun, 2011 Peer-reviewed
Lipid Rafts and Caveolin-1 Are Required for Invadopodia Formation and Extracellular Matrix Degradation by Human Breast Cancer Cells

Hideki Yamaguchi, Yukiko Takeo, Shuhei Yoshida, Zen Kouchi, Yoshikazu Nakamura, Kiyoko Fukami

CANCER RESEARCH, 69(22) 8594-8602, Nov, 2009
Phospholipase C-delta 1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development

Yoshikazu Nakamura, Manabu Ichinohe, Masayuki Hirata, Hirokazu Matsuura, Takashi Fujiwara, Takahiro Igarashi, Masamichi Nakahara, Hideki Yamaguchi, Sadao Yasugi, Tadaomi Takenawa …

FASEB JOURNAL, 22(3) 841-849, Mar, 2008
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression.

Asako Sakaue-Sawano, Hiroshi Kurokawa

Cell, 132 341-43, 2008
Phospholipase C-delta 1 and -delta 3 are essential in the trophoblast for placental development

Y Nakamura, Y Hamada, T Fujiwara, H Enomoto, T Hiroe, S Tanaka, M Nose, M Nakahara, N Yoshida, T Takenawa …

MOLECULAR AND CELLULAR BIOLOGY, 25(24) 10979-10988, Dec, 2005
Phospholipase C delta-type consists of three isozymes: bovine PLC delta 2 is a homologue of human/mouse PLC delta 4

Y Irino, HY Cho, Y Nakamura, M Nakahara, M Furutani, PG Suh, T Takenawa, K Fukami

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 320(2) 537-543, Jul, 2004
Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase

R Ban, Y Irino, K Fukami, H Tanaka

JOURNAL OF BIOLOGICAL CHEMISTRY, 279(16) 16394-16402, Apr, 2004
Evidence that activation of Src family kinase is not required for fertilization-associated [Ca²⁺] oscillations in mouse eggs

Reproduction, 127, 441-454, 2004
Recombinant phospholipase C-zeta has high Ca²⁺-sensitivity and induces Ca²⁺-oscillations in mouse eggs

J Biol Chem, 279, 10408-10412, 2004
Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling

K Takenaka, K Fukami, M Otsuki, Y Nakamura, Y Kataoka, M Wada, K Tsuji, SI Nishikawa, N Yoshida, T Takenawa

MOLECULAR AND CELLULAR BIOLOGY, 23(20) 7329-7338, Oct, 2003
Phospholipase C delta(1) is required for skin stem cell lineage commitment

Y Nakamura, K Fukami, HY Yu, K Takenaka, Y Kataoka, Y Shirakata, SI Nishikawa, K Hashimoto, N Yoshida, T Takenawa

EMBO JOURNAL, 22(12) 2981-2991, Jun, 2003
Phospholipase Cδ1 is required for skin stem cell lineage commitment.

Yoshikazu Nakamura, Kiyoko Fukami

EMBO J., 22(12) 2981-2991, 2003
Phospholipase Cδ4 is required for [Ca2+]i mobilization essential for acrosome reaction in sperm.

Kiyoko Fukami, Manabu Yoshida

J. Cell Biol., 161(1) 79-88, 2003
Phospholipase Cδ4 is required for [Ca2+]i mobilization essential for acrosome reaction

J. Cell Biol, 161(1) 79-88, 2003
Phospholipase Cδ4 : from genome structure to physiological function

Advan. Enzyme Regul, 43, 87-106, 2003
Co-signaling of NCAM via lipid rafts and the EGF receptor is required for neuritogenesis

J. Cell Biol, 157, 521-532, 2002
Structure, regulation, and function of phospholipase C isozymes

J. Biochem, 131, 293-299, 2002
Requirement of phospholipase C delta 4 for the zona pellucida-induced acrosome reaction

K Fukami, K Nakao, T Inoue, Y Kataoka, M Kurokawa, RA Fissore, K Nakamura, M Katsuki, K Mikoshiba, N Yoshida …

SCIENCE, 292(5518) 920-923, May, 2001

Books and Other Publications

ホスホリパーゼCによるイノシトールリン脂質代謝と疾患制御

深見希代子 (Role: Joint author)

医歯薬出版, 2019
遺伝子工学II

深見希代子 (Role: Joint editor)

東京化学同人, 2018
炎症性皮膚疾患とイノシトールリン脂質代謝系

深見希代子 (Role: Joint author)

羊土社, 2015
表皮におけるイノシトールリン脂質代謝の役割

深見希代子 (Role: Joint author)

生化学ミニレビュー, 2014
Regulation of α-actiuin and vinculin functions by polyphosphoinositides

G protein, Cytoskeleton and Cancer, 1998
PIP₂とタンパク質相互作用

タンパク質の分子間相互作用実験法, 1996
核内イノシトールリン脂質情報伝達系

脂質研究の新展開, 1996
ホスホリパーゼC,ホスホリパーゼA2,ホスホリパーゼD

脳,神経蛋白質,接着蛋白質(広川書店), 1995
リン脂質代謝からのシグナル発信

癌遺伝子と癌抑制遺伝子, 1994
細胞増殖とイノシトールリン脂質代謝

癌化のシグナル伝達機構, 1994
イノシトールリン脂質と細胞骨格

細胞骨格と細胞内シグナル伝達, 1993
イノシトールリン脂質による細胞構築シグナルの発生

情報伝達研究の新しい展開(羊土社), 1993
細胞増殖とイノシトールリン脂質代謝

細胞増殖の制御(南江堂), 1993
細胞増殖へのシグナル-イノシトールリン脂質情報伝達系

生体における情報伝達(南江堂), 1993
イノシトールリン脂質代謝系

朝倉書店
イノシトールリン脂質と細胞骨格調節タンパク質の相互作用

高次機能を司る役者達(細胞工学)

Professional Memberships

Research Projects

リン脂質が制御する上皮細胞の特性と疾患発症機構

基盤研究（B）, 科学研究費, Apr, 2017 - Mar, 2020

深見希代子
リン脂質の代謝異常から紐解く疾患制御機構の解明

AMED-CREST, AMED, 2013 - Mar, 2019

深見希代子
表皮の増殖・分化異常がもたらす疾患制御機構の解明

基盤研究（B）, 科学研究費, Apr, 2014 - Mar, 2017

深見希代子
リン脂質代謝を介した増殖・分化制御機構の解明：日本発創薬への基盤作り

最先端・次世代研究開発支援プログラム, 内閣府, 2011 - 2014

深見希代子
Lineagement of skin stem cell

Grant-in-Aid for Scientific Research
The role of phosphoinositide turnover in fertilization.

Grant-in-Aid for Scientific Research
Signal transduction in cell growth

Grant-in-Aid for Scientific Research