UNNO Toshihiro

J-GLOBAL         Last updated: Jul 2, 2019 at 02:42
UNNO Toshihiro
Gifu University
Faculty of Applied Biological Sciences
Master(Gifu University), Doctor(Gifu University)


Signal transduction mechanisms for muscarinic receptor./Regulation of ionic channels./Pathophysiologocal mechanisms for overactive bladder./Pathophysiologocal mechanisms for irritable bowel syndrom.

Research Areas


Academic & Professional Experience

Associate Professor, Gifu University Faculty of Applied Biological Sciences, Veterinary Medicine Course
Banyu Pharmaceutical Co., Central Research Lab., Research
Gifu University, Research Assistant
London University, St George's Hospital Medical School, Researcher


Graduate School, Division of Agriculture, Gifu University
Faculty of Agriculture, Gifu University

Committee Memberships

The Japanese Pharmacological Society  The Japanese Pharmacological Society
The Japanese Society of Veterinary Science  The Japanese Society of Veterinary Science
The Japan Society of Smooth Muscle Research  The Japan Society of Smooth Muscle Research

Published Papers

Characteristics of antiarrhythmic drugs.
Journal of Small Animal Medicine   5(2) 26-36   Apr 2003   [Invited]
Kwon Seong-Chun(Kwandong University College of Medicine)
British Journal of Pharmacology   139 337-350   May 2003
Effects of G-protein-specific antibodies and Gbeta-ganma subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.
Tsytsyura Ya(A.A. Bogomoletz Institute of Physiology),Prestwich Sally(St George's Hospital Medial School),Zholos Alexander(St George's Hospital Medial School),Bolton Thomas(St George's Hospital Medial School)
British Journal of Pharmacology   139 605-615   Jun 2003
Interaction between M2- and M3-receptor subtypes in the muscarinic electrical and mechanical responses of intestinal smooth muscles
Neurophysiology   35(3) 290-301   Nov 2003
Muscarinic signal transduction in gastrointestinal smooth muscle.
Recent Research Development of Physiology   577-597   Dec 2003


Yasuyuki Tanahashi, Ban Wang, Yuri Murakami, Toshihiro Unno, Hayato Matsuyama, Hiroshi Nagano, Seiichi Komori
Journal of Veterinary Medical Science   78 203-211
© 2016 The Japanese Society of Veterinary Science. In order to investigate the effects of SKF96365 (SKF), which is a non-selective cationic channel blocker, on K+ channel currents, we recorded currents through ATP sensitive K+ (IKATP), voltage-gat...
Ken Ichi Kinoshita, Yayoi Tada, Yoshikage Muroi, Yoshikage Muroi, Toshihiro Unno, Toshihiro Unno, Toshiaki Ishii, Toshiaki Ishii
Life Sciences   137 28-36
© 2015 Elsevier Inc. All rights reserved. Aims: Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). In PD, thinking and retrieva...
Suppression of voltage-gated Ca2+ channel currents in mouse intestinal smooth muscle cells.
Wess Jurgen(NIH-NIDDKD)
Hidenori OHASHI, Seiichi KOMORI, Seong-Chun KWON, Toshihiro UNNO
Japanese Journal of Veterinary Science   51(1) 17-28   1988

Books etc

May 2004   
Apr 2008   
Oct 2009   
Feb 2010   
Feb 2010   

Conference Activities & Talks

Wess Jurgen(NIH)
Apr 2004   


Regulatory mechanisms of voltage-gated Ca channels in intestinal smooth muscle.
1996 - 1998
Signal transduction mechanisms of muscarinic receptors in intestinal smooth muscle.
1998 - 2000
Molecular cloning of non selective cation channels in smooth muscle cells.
2001 - 2004
Muscarinic signal transduction mechanisms in smooth muscle cells studied using receptor subtype knockout mice.
Mechanisms of muscarinic contraction in intestinal smooth muscles.
2001 - 2002

Research Grants & Projects

Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2008 - 2010    Investigator(s): Toshihiro UNNO
In the present study, we attempted to clarify the phathogenetical mechanisms for the development of overactive bladder and investigated contractile responses of bladder smooth muscles to electrical field stimulation of intrinsic nerves in model mo...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2005 - 2006    Investigator(s): Toshihiro UNNO
We have studied the functional roles of M_2 and M_3 subtypes of muscarinic receptors in the cholinergic nerve-bladder smooth muscle transmission, aiming to propose the strategy for development of effective drugs treating for the overactive bladder...
Signal transduction mechanisms for receptor agonists in smooth muscle cells
Regulatory mechanisms of ion channels in smooth muscle cells.
Research on mechanism of action in ion channel modulator.