2013年
Influence of vaccination dose and clinico-demographical factors on antibody titers against measles, rubella, mumps, and varicella-zoster viruses among university students in Japan
Japanese Journal of Infectious Diseases
- ,
- ,
- ,
- 巻
- 66
- 号
- 6
- 開始ページ
- 497
- 終了ページ
- 502
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.7883/yoken.66.497
To evaluate the influence of vaccination dose and clinico-demographical factors on immune status against measles, rubella, mumps, and varicella viruses among university students, we conducted a case-control study by analyzing serum antibody titers according to past immunization and infection, and perinatal histories, using a multivariate regression model. A total of 1370 medical, paramedical, and pharmaceutical students were included in the analysis. Two or more doses of measles and rubella vaccination yielded notably greater odds ratios for immuno-positivity (9.1
95% confidence interval (CI), 2.8-28.9 and 12.2
95% CI, 0.71-210.3, respectively), compared with 1-dose vaccination, even though the superiority did not reach statistical significance for rubella. Students having younger/older siblings were more likely to be immuno-positive for mumps (2.5
95% CI, 1.3-4.9 and 2.7
95% CI, 1.4-5.5, respectively). On the other hand, post-term birth or macrosomia was associated with seronegative rubella virus antibodies. We concluded that a 2-dose vaccination strategy could successfully prevent measles and rubella outbreaks by increasing immunity.
95% confidence interval (CI), 2.8-28.9 and 12.2
95% CI, 0.71-210.3, respectively), compared with 1-dose vaccination, even though the superiority did not reach statistical significance for rubella. Students having younger/older siblings were more likely to be immuno-positive for mumps (2.5
95% CI, 1.3-4.9 and 2.7
95% CI, 1.4-5.5, respectively). On the other hand, post-term birth or macrosomia was associated with seronegative rubella virus antibodies. We concluded that a 2-dose vaccination strategy could successfully prevent measles and rubella outbreaks by increasing immunity.
- リンク情報
- ID情報
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- DOI : 10.7883/yoken.66.497
- ISSN : 1344-6304
- ISSN : 1884-2836
- J-Global ID : 201402255130738206
- CiNii Articles ID : 130003390328
- PubMed ID : 24270137
- SCOPUS ID : 84888105912