論文

査読有り
2005年9月

Assessment of human exposure to polychlorinated biphenyls and polybrominated diphenyl ethers in Japan using archived samples from the early 1980s and mid-1990s

ENVIRONMENTAL RESEARCH
  • A Koizumi
  • T Yoshinaga
  • K Harada
  • K Inoue
  • A Morikawa
  • J Muroi
  • S Inoue
  • B Eslami
  • S Fujii
  • Y Fujimine
  • N Hachiya
  • S Koda
  • Y Kusaka
  • K Murata
  • H Nakatsuka
  • K Omae
  • N Saito
  • S Shimbo
  • K Takenaka
  • T Takeshita
  • H Todoriki
  • Y Wada
  • T Watanabe
  • M Ikeda
  • 全て表示

99
1
開始ページ
31
終了ページ
39
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.envres.2004.12.002
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Persistent organic pollutants have been linked to various adverse effects on human health. We conducted a retrospective exposure assessment for 11polychlorinated biphenyl (PCB) congeners and 4 polybrominated diphenyl ether (PBDE) congeners. We analyzed paired samples of blood and food duplicate portions collected in the 1980s (1980 survey, N = 40) and the mid-1990s (1995 survey, N = 40) from females (five participants from each of eight sites per survey) living throughout Japan, from Hokkaido to Okinawa. The study populations in the 1980 and 1995 surveys were different but had lived in the same community. We measured PCBs and PBDEs in serum and PCBs in diet. Total serum PCBs (ng/g lipid) [geometric mean (geometric standard deviation)] were similar in the 1980 [163.0 (1.7)] and the 1995 [142.6 (2.0)] surveys. In contrast, dietary intake (ng/day) between 1980 and 1995 decreased significantly, from 522.8 (2.5) to 165.9 (3.3), respectively, (P < 0.05). We classified the participants by birth year-before 1941 (older generation) and equal to or after 1941 (younger generation). Serum PCB levels decreased significantly in the younger generation, from 179.1 (1.8) in the 1980 survey to 115.4 (2.0) in the 1995 survey (P < 0.05). However, in the older generation, serum levels (ng/g lipid) did not change: 150.4 (1.6) in the 1980 survey and 180 (1.8) in the 1995 survey. Total PBDE serum levels (ng/g lipid) increased significantly during the 15 years, from 0.5 (3.5) to 1.8 (3.7) (P < 0.05). At the Shimane site, PBDE serum levels (ng/g lipid) increased 20-fold, from 1.3 (4.8) to 26.0 (5.0). The serum levels of PCBs decreased in the younger generation but not in the older, although levels in daily intakes decreased significantly. Exposure levels of PBDEs appear to be increasing in an area-specific manner. (c) 2004 Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.envres.2004.12.002
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/16053925
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000231197400004&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.envres.2004.12.002
  • ISSN : 0013-9351
  • PubMed ID : 16053925
  • Web of Science ID : WOS:000231197400004

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