2005年7月
Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs
DIGESTIVE DISEASES AND SCIENCES
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- 巻
- 50
- 号
- 7
- 開始ページ
- 1264
- 終了ページ
- 1270
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1007/s10620-005-2770-y
- 出版者・発行元
- SPRINGER
It has been shown that acupuncture relieves symptoms of abdominal pain and bloating in patients with irritable bowel syndrome (IBS). However, the mechanism of beneficial effects of acupuncture still remains unproven. The aim of the present study was to investigate the mechanisms of the antinociceptive effects of acupuncture in conscious dogs. We evaluated the increase in mean arterial blood pressure (MAP) caused by rectal distension as an index of visceral pain. Electroacupuncture (EA; 10 Hz) at ST 36 (lower leg), but not at BL-21 (back), significantly reduced the increase in MAP in response to rectal distension (30 and 40 cm(3)). The antinociceptive effect of EA at ST-36 was abolished by pretreatment with naloxone (a central and peripheral opioid receptor antagonist) but not by naloxone methiodide (a peripheral opioid receptor antagonist). These results suggest that EA at ST-36 may reduce visceral pain via central opioid pathway. Acupuncture may be useful to treat visceral hypersensitivity in IBS patients.
- リンク情報
- ID情報
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- DOI : 10.1007/s10620-005-2770-y
- ISSN : 0163-2116
- Web of Science ID : WOS:000230392900013