FUJII Masayuki

J-GLOBAL         Last updated: Aug 5, 2019 at 17:40
 
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Name
FUJII Masayuki
Affiliation
Kindai University
Section
Faculty of Humanity-Oriented Science and EngineeringDepartment of Biological and Environmental Chemistry
Degree
(BLANK)

Research Areas

 
 

Education

 
 
 - 
1985
Graduate School, Division of Natural Science, Kyoto University
 
 
 - 
1983
Faculty of Science, Kyoto University
 

Published Papers

 
Selective Regulation of Expression of Mutant Oncogene KRAS(G12D) by siRNAs
FUJII Masayuki
30 1-7   Jun 2019   [Refereed]
Neutral and negatively charged phosphate modifications alter thermal stability, kinetics of formation and monovalent ion dependence of DNA G-quadruplexes
FUJII Masayuki
Chemistry An Asian Journal   14 1212-1220   2019   [Refereed][Invited]
Silencing of BCR/ABL Chimeric Gene in Human Chronic Myelogenous Leukemia Cell Line K562 by siRNA-Nuclear Export Signal Peptide Conjugates
FUJII Masayuki
Nucleic Acid Therapeutics   27(3) 168-175   Jun 2017   [Refereed]
Delivery of therapeutic RNA-cleaving oligodeoxyribonucleotides (deoxyribozymes): from cell culture studies to clinical trials
FUJII Masayuki
Expert Opinion of Drug Delivery   2016 1-13   Dec 2016   [Refereed][Invited]
FUJII Masayuki
Nucleosides, Nucleotides and Nucleic Acids   35(7) 370-378   Jul 2016   [Refereed]
Design of Nucleic Acid Therapeutics; Chemical Modification, Conjugation and Complexation
FUJII Masayuki
Med Chem News   26(1) 22-28   Jan 2016   [Refereed][Invited]
Gene Silencing by miRNA-like siRNAs Bearing Mismatches and Bulges
FUJII Masayuki
Proceedings of the 42nd International Symposium of Nucleic Acid Chemistry   2015 324-325   Nov 2015   [Refereed]
Gene Silencing by Chemically Modified siRNAs Bearing Cationic Charge on 5’-End
FUJII Masayuki
Proceedings of the 42nd International Symposium of Nucleic Acid Chemistry   2015 322-323   Nov 2015   [Refereed]
Synthesis, purification and delivery into mammalian cells of phosphoryl guanidine oligonucleotides (PGO) with either DNA or 2'-OMe RNA backbone
FUJII Masayuki
Proceedings of the 42nd International Symposium of Nucleic Acid Chemistry   2015 244-245   Nov 2015   [Refereed]
Rational Design of siRNA by Chemical Modification and Conjugation
FUJII Masayuki
Proceeding of the 11th Oligonucleotide Therapeutic Society Annual Meeting   2015 138-138   Sep 2015   [Refereed]
FUJII Masayuki
Bioconjugate Chemistry   26(8) 1830-1838   Aug 2015   [Refereed]
Molecular Design of Nucleic Acids Based on Structural Biology for Nucleic Acids Therapeutics
FUJII Masayuki
19(1) 7-7   Apr 2015
CATIONIC CHARGE ON SIRNA AND RNAI EFFECT
FUJII Masayuki
Proceedings of the XXI Round Table on Chemical Biology of Nucleic Acids   2014 143-143   Oct 2014   [Refereed]
EFFICIENT TRANSFECTION OF SIRNA BY DESIGNED PEPTIDES
FUJII Masayuki
Proceedings of International Symposium of Nucleic Acid Chemistry   2014 374-375   Sep 2014   [Refereed]
Gene Silencing by Cationic siRNA
FUJII Masayuki
Proceedings of International Symposium of Nucleic Acid Chemistry   2014 328-329   Sep 2014   [Refereed]
Non-Toxic Delivery and Gene Silencing by siRNA-Peptide Complex
FUJII Masayuki
Biopolymers   100(3) 265-265   Dec 2013   [Refereed]
Structure of Human Argonaute2 Protein and Chemically Modified siRNA
FUJII Masayuki
Proceedings of International Symposium of Nucleic Acid Chemistry   2013 318-319   Nov 2013   [Refereed]
Chemical modification of siRNAs and their silencing effects
FUJII Masayuki
Proceedings of the 9th Annual Meeting of the Oligonucleotide Therapeutics Society   2013 108-108   Oct 2013   [Refereed]
FUJII Masayuki
Nucleic Acids Research   41(18) 8581-8590   Sep 2013   [Refereed]
Non-toxic delivery of siRNA by amphiphilic peptides and silencing of hTERT
Journal of Peptide Science   18 498-499   Sep 2012
Specific Delivery of siRNA by Amphiphilic Peptide-Signal Peptide Conjugates
FUJII Masayuki
Proceedings of International Symposium of Nucleic Acid Chemistry   2012 128-129   Sep 2012   [Refereed]
Organic & Biomolecular Chemistry   10 9664-9670   2012
Specific Delivery of siRNA by Hybrid Peptides and Silencing of hTERT
FUJII Masayuki
Proceedings of the 11thUS-Japan Symposium on Drug Delivery System   2011 29-29   Dec 2011   [Refereed]
Suppression of bcr/abl gene expression by siRNA conjugates
FUJII Masayuki
Nucleic Acid Therapeutics   21(5) 8-8   Nov 2011   [Refereed]
NON-TOXIC DELIVERY OF siRNA BY HYBRID PEPTIDES AND SILENCING OF hTERT
FUJII Masayuki
Proceedings of the 7th Oligonucleotide Therapeutic Society Meeting   2011 65-65   Oct 2011   [Refereed]
Suppression of bcr/abl gene expression by siRNA conjugates
FUJII Masayuki
Proceedings of the 6th Cambridge Symposium   2011 26-26   Sep 2011   [Refereed]
Specific Delivery of siRNA by Hybrid Peptides and Silencing of hTERT
FUJII Masayuki
Proceedings of International Symposium of Nucleic Acid Chemistry   2011 108-109   Sep 2011   [Refereed]
Suppression of Telomerase Activity and Proliferation of Human Cancer Cells by anti-hTERT siRNAs and anti-hTR S-OligoDNA-Signal Peptide Conjugates
FUJII Masayuki
14 5-21   Jul 2011   [Refereed]
Synthesis, Delivery and Gene Silencing of siRNA-NES Conjugates
Progress in Drug Delivery Systems   2011(10) 91-96   Jul 2011
Suppression of Telomerase Activity and Proliferation of Human Cancer Cells by anti-hTERT siRNAs and anti-hTR S-OligoDNA-Signal Peptide Conjugates
14(2) 5-21   Feb 2011
Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions
Journal of Nucleic Acids   2011 1-11   Jan 2011
Synthesis of and gene silencing by oligonucleotide-peptide conjugates
FUJII Masayuki
Peptide Science   2010 380-380   Oct 2010   [Refereed]
Highly Enhanced Silencing of bcr/abl Gene by siRNA-NES Peptide Conjugates
FUJII Masayuki
Peptide Science   2010 379-379   Oct 2010   [Refereed]
Synthesis of Oligonucleotide-Peptide Conjugates by Solid Phase Fragment Condensation
FUJII Masayuki
Peptide Science   2010 381-381   Oct 2010   [Refereed]
Controlled Intracellular Delivery and Antisense Inhibition of DNA-Peptide Conjugates
FUJII Masayuki
Peptide Science   2010 382-382   Oct 2010   [Refereed]
Specific Inhibition of Human Telomerase Activity by siRNA and Phosphorothioate Oligonucleotide-Peptide Conjugates
FUJII Masayuki
Peptide Science   2010 383-383   Oct 2010   [Refereed]
Synthesis of siRNA-Peptide Conjugates by Solid Phase Fragment Condensation
Nucleosides, Nucleotides and Nucleic Acids   29「(8) 546-547   Aug 2010
Suppression of Telomerase Activity and Proliferation of Cancer Cell Lines by siRNA Targeting hTERT mRNA
Nucleosides, Nucleotides and Nucleic Acids   29(8) 542-543   Aug 2010
Specific Suppression of bcr/abl mRNA by Chemically Modified siRNAs Targeting b3a2 Transcripts
Nucleosides, Nucleotides and Nucleic Acids   29(8) 548-549   Aug 2010
Highly Enhanced Silencing Effect by siRNA-Nuclear Eeport Signal Peptide Conjugates
Nucleosides, Nucleotides and Nucleic Acids   29(8) 544-545   Aug 2010
FUJII Masayuki
Molecular BioSystems   6 2023-2029   Jun 2010   [Refereed]
FUJII Masayuki
Biochemistry   48(47) 11304-11311   Dec 2009   [Refereed]
Current Organic Chemistry   13(14) 1366-1377   Aug 2009
Suppression of bcr-abl mRNA by Chemically Modified siRNA
Nucleic Acids Symp. Ser.   52 499-500   Sep 2008
Antisense Inhibition of Human Telomerase by Phosphorothioate Oligonucleotide-Peptide Conjugates
Nucleic Acids Symp. Ser.   52 679-680   Sep 2008
Functionalization of DNA by the base pair-mimic nucleosides
Nucleic Acids Symposium Series   51 151-152   Nov 2007
The base-pairing ability of the base pair-mimic nucleosides
Nucleic Acids Symposium Series   51 71-72   Nov 2007
Bioorganic & Medicinal Chemistry Letters   17(23) 6576-6578   Jun 2007
Recognition of the base pair-mimic nucleosides by DNA polymerase
Nucleic Acids Research   50 201-202   Nov 2006
Mechanism of reaction efficiency enhancement in microchannels studied by spectroscopic visualization and numerical simulation
Micro Total Analysis Systems 2006   1336-1338   2006
Nucleic Acids Research   33(22) 7111-7119   Oct 2005
Suppression of bcr/abl chimeric gene by conjugate DNA enzymes in human cells
Nucelic Acids Research   49 333-334   Sep 2005
Highly sensitive inhibition of hTERT mRNA expression and telomerase activity by DNA-signal peptide conjugates
Nucleic acids Research   49 337-338   Sep 2005
Journal of the American Chemical Society   127 518-519   Jan 2005
Precisely controlled intracellular delivery of DNA-peptide conjugate
Nucleic Acids Symposium Series   48 99-100   2005
Control of intracellular delivery of oligonucleotides by signal peptides and genetic expression in human cells
Nucleic Acids Symposium Series   48 303-304   2005
Control of intracellular delivery of oligonucleotides by signal peptides and genetic expression in human cells
FUJII Masayuki
Nucelic Acids Symp. Ser   48 303-304   Nov 2004   [Refereed]
Precisely controlled interacellular delivery of DNA-peptide conjugates
FUJII Masayuki
Nucelic Acids Symp. Ser   48 99-100   Nov 2004   [Refereed]
Conformational change of a nucleotide by a base-pair mimic nucleoside in the complementary DNA strand
FUJII Masayuki
Nucelic Acids Symp. Ser   48 259-260   Nov 2004   [Refereed]
Precisely controlled interacellular delivery of DNA-peptide conjugates
Nucleic Acids Research   48 99-100   Oct 2004
Control of intracellular delivery of oligonucleotides by signal peptides and genetic expression in human cells
Nucleic Acids Research   48 303-304   Oct 2004
Atypical protein-kinase Cbut neither conventional Ca2+-dependent protein-kinase C isoenzymesnor Ca2+-calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells
FUJII Masayuki
Cancer Chemother. Pharmacol   54 161-172   Sep 2004   [Refereed]
FUJII Masayuki
Chem. Eng. J   101 277-284   Jun 2004   [Refereed]
Atypical protein-kinase C???but neither conventional Ca2+-dependent protein-kinase C isoenzymes?nor Ca2+-calmodulin, participates in regulation of telomerase activity in Burkitt's lymphoma cells
Cancer Chemotherapy and Pharmacology   54 161-172   Feb 2004
New J ournal of Chemistry   28 1622-1626   Jan 2004
Visualization of Fluidic and Reaction Dynamics in Microchannels
The first international symposium on micro & nano technology      2004
Synthesis and Biological Activity of Phosphorothioate DNA-Peptide Conjugate
FUJII Masayuki
Annals   2003 106-109   Oct 2003   [Refereed]
Synthesis of DNA-Peptide Conjugate by Solid Phase Fragment Condensation
Peptide Science   2001 339-342   Feb 2002
A Novel Approach for the Solid Phase Synthesis of DNA Peptide Conjugates
Peptide Science   2000 23-26   2001

Misc

 
Stereoselective Synthesis of (±)-Isonirtramine and (±)-Sibirine
Chemistry Letters   8,1493    1992
A Noel Coenzyme NAD(P)+-NAD(P)H Model with Axial Chirality
Journal of Chemical Society, Chemical Communications   7,905    1992
A New Method for Preparation of Conjugated Nitro Alkenes
Chemistry Letters   6,933    1992
Studies on the Reaction Mechanism of the Photochemical Desulfonylation from β-Keto Sulfone by a Coenzyme NADH Model
Chemistry Express   7(5) 377   1992

Books etc

 
Handbook for Nucleic Acid Science
FUJII Masayuki (Part:Contributor, Peptide-Nucleic Acid Conjugates)
Kodansha Scientific, Inc   Jan 2020   
Utilities of 1.4-Dihydropyvidines in Synthetic Organic Chemistry
Trends in Heterocyclic Chemistry   1997   
Synthesis, Biological Properties, and Antisense Effects of Oligonucleotide-Peptide Conjugates
Advances in Oragnic Chemistry(分担執筆) Bentham Science PublisherLTD.,USA   2005   
Fronteers in Organic Chemistry, Synthesis, Biological Properties, and Antisense Effects of Oligonucleotide-Peptide Conjugates
Bentham Science Publisher Ltd   Jan 2005   
Non-viral Gene Therapy: Gene Design and Delivery,, Controlled Intracellular Localization of Oligonucleotides by Chemical Conjugation
Springer-Verlag   May 2005   

Conference Activities & Talks

 
Discrimination of Point Mutation of KRAS Gene by Gapmer ASO and siRNA
FUJII Masayuki
10 Jul 2019   
Selective Suppression of Mutant KRAS(G12D) Gene by Antisense Oligonucleotides and siRNAs
FUJII Masayuki
The 45th International Symposium of Nucleic Acid Chemistry   7 Nov 2018   
Chemistry and Biology of Nucleic Acid Conjugates as Therapeutic Agents [Invited]
FUJII Masayuki
Advances in Noncanonical Nucleic Acids 2018   25 Oct 2018   
A Universal Synthesis of DNA/RNA Multiple Conjugates by Chemo-Enzymatic Approach
FUJII Masayuki
14 Nov 2017   
A Facile Synthesis of DNA/RNA Multiple Conjugates by Chemo-enzymatic Approach
FUJII Masayuki
13th Annual Meeting Oligonucleotide Therapeutics Society   24 Sep 2017   

Works

 
Development of Gene Knock Down Method
2001

Research Grants & Projects

 
RNA INTERFERENCE by siRNAs BEARING 5’-AMINO-5’-DEOXYTHYMIDINE
Project Year: Jul 2016 - Jul 2016    Investigator(s): FUJII Masayuki
A Novel Coenzyme NADH Model with Axial Chirality. Its preparation and Stereoselectivity
Project Year: Aug 1991 - Aug 1991    Investigator(s): FUJII Masayuki
Sequence Specific Recognition of DNA and RNA
Artificial Restriction Enzyme with Sequence Specific Recognition
Therapeutic Reagents for Vero Toxin from E.Coli

Patents

 
特許China Patent 2310709 : Method for transfecting nucleic acid to cell and nucleic acid complex
FUJII Masayuki
特許EU2594638 : Method for transfecting nucleic acid to cell and nucleic acid complex
FUJII Masayuki
特許US9,057,067 : Method for transfecting nucleic acid to cell and nucleic acid complex
FUJII Masayuki

Others

 
Apr 2017   Suppression of Mutant KRAS Gene by Nucleic Acid Therapeutics and Development of Innovative Anticancer Drug
This research project is aiming to develop an innovative nucleic acid therapeutics targeting undruggable mutant KRAS positive cancers.