Hiroyuki Kamiya

Profile Information

Affiliation: Associate Professor, Hiroshima University

Degree: 博士（薬学）(北海道大学)

J-GLOBAL ID: 200901045869553044
researchmap Member ID: 1000172711

Research Interests

Research Areas

Life sciences / Pharmaceuticals - health and biochemistry /

Research History

Apr, 2019 - Present

Hiroshima University
Jul, 2014 - Mar, 2019

Graduate School of Biomedical Sciences, Hiroshima University
Nov, 2010 - Jun, 2014

Graduate School of Science and Engineering, Ehime University
Jul, 2000 - Oct, 2010

Hokkaido University

Education

Apr, 1988 - Jun, 1988

Hokkaido University
Apr, 1986 - Mar, 1988

Hokkaido University
Apr, 1982 - Mar, 1986

Department of Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University

Committee Memberships

Awards

Papers

256

Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine.

Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya

Mutation research, 825 111794-111794, 2022
Gene correction by 5'-tailed duplexes with short editor oligodeoxyribonucleotides.

Hidehiko Kawai, Kentaro Yazama, Yuri Yanai, Ryotaro Kamitsubo, Hiroyuki Kamiya

Journal of bioscience and bioengineering, Sep 10, 2021 Peer-reviewed
Action-at-a-distance mutations at 5'-GpA-3' sites induced by oxidized guanine in WRN-knockdown cells.

Tetsuya Suzuki, Hiroshi Masuda, Madoka Mori, Rikako Ito, Hiroyuki Kamiya

Mutagenesis, Jul 17, 2021 Peer-reviewed
Similar frequency and signature of untargeted substitutions induced by abasic site analog under reduced human APE1 conditions

Tetsuya Suzuki, Yuri Katayama, Yasuo Komatsu, Hiroyuki Kamiya

JOURNAL OF TOXICOLOGICAL SCIENCES, 46(6) 283-288, 2021 Peer-reviewed
Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells.

Ayuna Takeishi, Hiroyuki Kogashi, Mizuki Odagiri, Hiroyuki Sasanuma, Shunichi Takeda, Manabu Yasui, Masamitsu Honma, Tetsuya Suzuki, Hiroyuki Kamiya, Kaoru Sugasawa …

PloS one, 15(12) e0244790, Dec, 2020 Peer-reviewed
New indicator Escherichia coli strain for rapid and accurate detection of supF mutations.

Ruriko Fukushima, Tetsuya Suzuki, Hiroyuki Kamiya

Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 42 28, Sep, 2020 Peer-reviewed
Single-stranded DNA versus tailed duplex in sequence conversion oflacZ alpha DNA

Hidehiko Kawai, Kento Sato, Wataru Shirahama, Tetsuya Suzuki, Hiroyuki Kamiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 39(9) 1245-1250, Sep, 2020 Peer-reviewed
High-throughput analysis of DNA repair in microplates towards identification of inhibitors.

Hiroyuki Kamiya

Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 42 11, Mar, 2020 Peer-reviewed
Conventional plasmid DNAs with a CpG-containing backbone achieve durable transgene expression in mouse liver

Tetsuya Suzuki, Yusuke Wakao, Takuya Goda, Hiroyuki Kamiya

JOURNAL OF GENE MEDICINE, 22(1) e3138, Jan, 2020 Peer-reviewed
Large deletions and untargeted substitutions induced by abasic site analog on leading versus lagging strand templates in human cells.

Suzuki T, Katayama Y, Komatsu Y, Kamiya H

Mutagenesis, 34 421-429, Nov, 2019 Peer-reviewed
プラスミド特異的ヒストンアセチル化酵素リクルートシステムの効果はin vivoでは観察されない

紙谷浩之, 鈴木哲矢, 若尾祐介, 渡部匡史, 堀美香, 池田義人, 土谷博之, 小暮健太朗, 斯波真理子, 藤室雅弘

日本DDS学会学術集会プログラム予稿集, 35回 182-182, Jun, 2019
No enhancing effects of plasmid-specific histone acetyltransferase recruitment system on transgene expression in vivo.

Tetsuya Suzuki, Yusuke Wakao, Tadashi Watanabe, Mika Hori, Yoshito Ikeda, Hiroyuki Tsuchiya, Kentaro Kogure, Mariko Harada-Shiba, Masahiro Fujimuro, Hiroyuki Kamiya

Nucleosides, nucleotides & nucleic acids, 38(12) 942-949, 2019 Peer-reviewed
Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase λ-double knockdown cells

H. Kamiya, T. Makino, T. Suzuki, M. Kobayashi, I. Matsuoka

Mutagenesis, 33(4) 301-310, Oct, 2018 Peer-reviewed
Analysis of large deletion mutations induced by abasic site analog in human cells

T. Suzuki, Y. Katayama, Y. Komatsu, H. Kamiya

Genes Environment, 40 24, Oct, 2018 Peer-reviewed
Durable Transgene Expression Driven by CpG-Free and -Containing Promoters in Plasmid DNA with CpG-Free Backbone.

Suzuki T, Goda T, Kamiya H

Biological & Pharmaceutical Bulletin, 41(9) 1489-1493, Sep, 2018 Peer-reviewed
Reduction of Werner Syndrome Protein Enhances G:C → A:T Transition by O6-Methylguanine in Human Cells

Tetsuya Suzuki, Yoshie Kuramoto, Hiroyuki Kamiya

Chemical Research in Toxicology, 31(5) 319-324, May 21, 2018 Peer-reviewed
Effects of mismatches distant from the target position on gene correction with a 5′-tailed duplex

Tetsuya Suzuki, Yuri Yanai, Natsuki Nishigaki, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Hiroyuki Kamiya

Journal of Bioscience and Bioengineering, 125(5) 619-623, May 1, 2018 Peer-reviewed
Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase

Mika Nishihara, Genki N. Kanda, Tetsuya Suzuki, Shin'ichiro Yamakado, Hideyoshi Harashima, Hiroyuki Kamiya

JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 123(3) 277-280, Mar, 2017 Peer-reviewed
Mutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cells

Tetsuya Suzuki, Hiroyuki Kamiya

Genes and Environment, 39(1) 2, 2017 Peer-reviewed
Comparison of DNA fragments as donor DNAs upon sequence conversion of cleaved target DNA

Tetsuya Suzuki, Takashi Imada, Yasuo Komatsu, Hiroyuki Kamiya

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 36(6) 428-434, 2017 Peer-reviewed

Misc.

プラスミドDNA結合ヒストンの特異的アセチル化による外来遺伝子発現上昇

紙谷浩之, 紙谷浩之, 紙谷浩之, 西原実香, 西原実香, 神田元紀, 神田元紀, 鈴木哲矢, 山門振一郎, 原島秀吉

日本DDS学会学術集会プログラム予稿集, 32nd, 2016
S1-2 Action-at-a-distance (non targeted) mutations induced by 8-hydroxyguanine in human cells(Symposium 1 Biological Effects of Oxidative Stress)

Kamiya Hiroyuki

(44) 64-64, 2015
Transcription of 4 '-thioDNA templates to natural RNA in vitro and in mammalian cells (vol 51, pg 7887, 2015)

Hideto Maruyama, Kazuhiro Furukawa, Hiroyuki Kamiya, Noriaki Minakawa, Akira Matsuda

CHEMICAL COMMUNICATIONS, 51(43) 9054-9054, 2015
プラスミドDNA特異的ヒストン修飾による導入遺伝子発現上昇

西原実香, 神田元紀, 神田元紀, 山門振一郎, 原島秀吉, 原島秀吉, 紙谷浩之, 紙谷浩之, 紙谷浩之

日本DDS学会学術集会プログラム予稿集, 30th, 2014
特異的ヒストン修飾による導入プラスミドDNAの発現上昇

西原実香, 神田元紀, 神田元紀, 山門振一郎, 原島秀吉, 原島秀吉, 紙谷浩之, 紙谷浩之, 紙谷浩之, 紙谷浩之

日本分子生物学会年会プログラム・要旨集(Web), 37th, 2014
P-083 The Werner syndrome protein promotes mutagenesis induced by 8-hydroxyguanine paired with adenine

Kamiya Hiroyuki, Nakamura Eri, Makino Tetsuaki, Kobayashi Miwako, Matsuoka Ichiro

(43) 132-132, 2014
In vivoにおける外来遺伝子発現の持続を達成するDNA配列の同定

神田元紀, 神田元紀, 神田元紀, 小林三和子, 松岡一郎, 原島秀吉, 原島秀吉, 紙谷浩之, 紙谷浩之, 紙谷浩之

日本分子生物学会年会プログラム・要旨集(Web), 36th, 2013
P-072(O-13) Relationship between DNA polymerase λ and mutagenesis by oxidative DNA damage in human cells(Poster presentation)

Makino Tetsuaki, Kurokawa Masahiro, Kobayashi Miwako, Matsuoka Ichiro, Kamiya Hiroyuki

(42) 110-110, 2013
クロマチン化プラスミドDNAはin vivoにおいて外来遺伝子発現を上昇させる

紙谷浩之, 紙谷浩之, 紙谷浩之, 紙谷浩之, 宮本紫甫, 後藤仁美, 神田元紀, 神田元紀, 小林三和子, 松岡一郎 …

日本分子生物学会年会プログラム・要旨集(Web), 35th, 2012
クロマチン化プラスミドDNAによる発現上昇

紙谷浩之, 紙谷浩之, 紙谷浩之, 紙谷浩之, 宮本紫甫, 後藤仁美, 神田元紀, 神田元紀, 小林三和子, 松岡一郎 …

日本DDS学会学術集会プログラム予稿集, 28th, 2012
P-054 Mutagenic bypass of 8-hydroxyguanine by DNA polymerase κ in human cells(II. DNA Damage and Repair,Poster Presentation)

Kamiya Hiroyuki, Kurokawa Masahiro

(41) 117-117, 2012
P-091 Influences of reduced Werner syndrome protein level on mutagenesis by 8-hydroxyguanine(Poster Presentation)

Kamiya Hiroyuki, Yamazaki Daiki, Harashima Hideyoshi

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, (40) 138-138, Oct 20, 2011
マウス肝臓におけるleft-handedly curved配列を付加したプラスミドからの外来遺伝子発現上昇

神田元紀, 神田元紀, 神田元紀, 福永賢輝, 棚瀬潤一, 原島秀吉, 原島秀吉, 大山隆, 紙谷浩之, 紙谷浩之 …

日本分子生物学会年会プログラム・要旨集(Web), 34th, 2011
P-012 Effects of p53- and Rb-knockdowns on mutations induced by 8-hydroxyguanine(Poster Presentation)

Kamiya Hiroyuki, Suzuki Tetsuya, Harashima Hideyoshi

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, (39) 98-98, Oct 29, 2010
8‐Hydroxy‐dGTP(8‐oxo‐7,8‐dihydro‐dGTP)二次酸化産物の変異誘発能

紙谷浩之, 堀美香, 原島秀吉

日本放射線影響学会大会講演要旨集, 53rd 91-91, Oct 1, 2010
プラスミド‐ヒストン複合体からの外来遺伝子発現効率

紙谷浩之, 紙谷浩之, 後藤仁美, 後藤仁美, 神田元紀, 神田元紀, 山田勇磨, 山田勇磨, 原島秀吉, 原島秀吉

薬剤学, 70(Supplement) 148, Apr 20, 2010
2種類の「発現持続型」プラスミドの核内挙動の違い

冨樫亮平, 冨樫亮平, 神田元紀, 神田元紀, 紙谷浩之, 紙谷浩之, 原島秀吉, 原島秀吉

生化学, 2010
内在性転写活性化因子を用いた細胞系における外来遺伝子発現の活性化

神田元紀, 神田元紀, 落合浩史, 落合浩史, 原島秀吉, 原島秀吉, 紙谷浩之, 紙谷浩之

生化学, 2010
自己活性化システムによるin vivo外来遺伝子発現上昇

神田元紀, 落合浩史, 原島秀吉, 紙谷浩之

遺伝子・デリバリー研究会シンポジウム要旨集, 10th, 2010
P-031 Involvement of translesion synthesis DNA polymerases in bypass of 8-hydroxyguanine(Replication and repair,Poster Session)

Kamiya Hiroyuki, Yamaguchi Ayaka, Suzuki Tetsuya, Harashima Hideyoshi

Taikai Program Yoshisyu of the Environmental Mutagen Society of Japan, (38) 116-116, Nov 6, 2009

Books and Other Publications

核酸医薬の最前線

紙谷浩之, 原島秀吉 (Role: Joint author, p. 76-84)

シーエムシー出版, Feb, 2009
バイオとナノの融合II〜新生命科学の応用

(Role: Joint author, p. 17-30)

北海道大学出版会, Mar, 2007

Major Professional Memberships

日本薬剤学会

Research Projects

老化細胞誘発クラスター性変異のNGS解析による放射線発がん機構研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

河合秀彦, 紙谷浩之
活性酸素と脱アミノ化酵素APOBEC3が誘発する遠隔作用変異の分子機構の解明

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2022 - Mar, 2025

紙谷浩之, 鈴木哲矢, 河合秀彦
Molecular mechanisms of action-at-a-distance mutations induced by DNA damage

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

KAMIYA Hiroyuki
Next generation genome editing without artificial nucleases

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jun, 2017 - Mar, 2020

KAMIYA Hiroyuki
Molecular mechanisms of action-at-a-distance mutations

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

KAMIYA Hiroyuki
Efficient and durable transgene expression systems

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Kamiya Hiroyuki
Action-at-a-distance mutations induced by 8-oxoguanine

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

KAMIYA Hiroyuki
MENDで拓く遺伝子治療への道：遺伝子の運び屋からナノマシンへ

科学研究費助成事業, 基盤研究(S), 日本学術振興会, May, 2010 - Mar, 2014

原島秀吉, 山田勇磨, 中村孝司, 兵藤守, 馬場嘉信, 篠原康雄, 小暮健太朗, 紙谷浩之, 渡慶次学, 松尾保孝, 秋田英万
Control of intranuclear disposition of DNA for gene therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

KAMIYA Hiroyuki, AKITA Hidetaka
染色体DNA標的部位のin vivo配列改変技術

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2009 - 2010

紙谷浩之
Multifunctional Envelope-type Nano Device as non-viral gene delivery system for cancer therapy

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2008 - 2009

HARASHIMA Hideyoshi
腫瘍関連遺伝子のゲノム(不)安定性に対する影響

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2008 - 2009

紙谷浩之
Development of in vivo gene delivery system for siRNA and genome wide screening of type-two diabetes related genes in mice and rats

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, 2006 - 2009

HARASHIMA Hideyoshi, KAMIYA Hiroyuki, YAMADA Yuma, BABA Yoshinobu
Novel DNAs for efficient and durable transgene expression

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2007

KAMIYA Hiroyuki, AKITA Hidetaka
がん選択的多機能性エンベロープ型ナノ構造体の開発とがん遺伝子治療への応用

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2006 - 2007

原島秀吉, 紙谷浩之, 秋田英万, 山田勇磨, 小暮健太朗
ミトコンドリアを標的とする多重型・多機能性エンベロープ型ナノ構造体の開発

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2005 - 2006

原島秀吉, 紙谷浩之, 秋田英万
Design of Novel DNAs for Gene Therapy with Nonviral Vectors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2005

KAMIYA Hiroyuki
2型糖尿病の遺伝子診断用候補遺伝子の網羅的解析及びその機能解析

科学研究費助成事業, 特定領域研究, 日本学術振興会, 2004 - 2004

原島秀吉, 馬場嘉信, 鈴木要介, 紙谷浩之
Development of Multifunctional Envelope type Nano Device based on Programmed Packaging

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2003 - 2004

HARASHIMA Hideyoshi, KAMIYA Hiroyuki, AKITA Hidetaka
ゲノム機能情報に基づいた糖尿病薬の処方設計支援システムの構築

科学研究費助成事業, 萌芽研究, 日本学術振興会, 2002 - 2004

原島秀吉, 桑島正道, 紙谷浩之

Profile Information

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Research History

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Awards

Papers

Misc.

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Major Professional Memberships

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