葛西宏 (Hiroshi Kasai) - マイポータル - researchmap

基本情報

所属: 産業医科大学産業生態科学研究所職業性腫瘍学教授

学位: 博士(理学)(学習院大学)

J-GLOBAL ID: 200901075193234397
researchmap会員ID: 1000172712

研究キーワード

2

研究分野

1

ライフサイエンス / 分子生物学 /

学歴

4

委員歴

2

1994年

日本環境変異原学会, 評議員
1994年

日本癌学会, 評議員

受賞

3

MISC

106

Urea, the most abundant component in urine, cross-reacts with a commercial 8-OH-dG ELISA kit and contributes to overestimation of urinary 8-OH-dG

Ming-Fen Song, Yun-Shan Li, Yuko Ootsuyama, Hiroshi Kasai, Kazuaki Kawai, Masanori Ohta, Yasumasa Eguchi, Hiroshi Yamato, Yuki Matsumoto, Rie Yoshida …

FREE RADICAL BIOLOGY AND MEDICINE 47(1) 41-46 2009年7月
DNA Methylation at the C-5 Position of Cytosine by Methyl Radicals: A Possible Role for Epigenetic Change during Carcinogenesis by Environmental Agents

Hiroshi Kasai, Kazuaki Kawai

CHEMICAL RESEARCH IN TOXICOLOGY 22(6) 984-989 2009年6月
Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine

Kazuyoshi Tamae, Kazuaki Kawai, Sayumi Yamasaki, Kiyoshi Kawanami, Masato Ikeda, Ken Takahashi, Toshiaki Miyamoto, Noritada Kato, Hiroshi Kasai

CANCER SCIENCE 100(4) 715-721 2009年4月
Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine

Kazuyoshi Tamae, Kazuaki Kawai, Sayumi Yamasaki, Kiyoshi Kawanami, Masato Ikeda, Ken Takahashi, Toshiaki Miyamoto, Noritada Kato, Hiroshi Kasai

CANCER SCIENCE 100(4) 715-721 2009年4月
4-oxo-2-hexenal, a mutagen formed by omega-3 fat peroxidation: Occurrence, detection and adduct formation

Hiroshi Kasai, Kazuaki Kawai

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 659(1-2) 56-59 2008年7月
Body mass index and oxidative DNA damage: A longitudinal study

Tetsuya Mizoue, Shoji Tokunaga, Hiroshi Kasai, Kazuaki Kawai, Masao Sato, Tatsuhiko Kubo

CANCER SCIENCE 98(8) 1254-1258 2007年8月
Increase of Urinary 8-OH-dG Levels after Administration of a Vitamin-deficient Diet and a Sweet Beverage

Yun-Shan Li, Kazuaki Kawai, Hiroshi Kasai

Genes and Environment 29(3) 128-132 2007年
Accurate Measurement of 8-OH-dG and 8-OH-Gua in Mouse DNA, Urine and Serum: Effects of X-ray Irradiation

Kazuaki Kawai, Yun-Shan Li, Hiroshi Kasai

Genes and Environment 29(3) 107-114 2007年
Detection of 4-oxo-2-hexenal, a novel mutagenic product of lipid peroxidation, in human diet and cooking vapor

K Kawai, K Matsuno, H Kasai

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 603(2) 186-192 2006年2月
Identification of 4-oxo-2-hexenal and other direct mutagens formed in model lipid peroxidation reactions as dGuo adducts

M Maekawa, K Kawai, Y Takahashi, H Nakamura, T Watanabe, R Sawa, K Hachisuka, H Kasai

CHEMICAL RESEARCH IN TOXICOLOGY 19(1) 130-138 2006年1月
Urinary 8-hydroxyguanine may be a better marker of oxidative stress than 8-hydroxydeoxyguanosine in relation to the life spans of various species.

Svoboda P, Maekawa M, Kawai K, Tominaga T, Savela K, Kasai H

Antioxid Redox Signal. 8 985-92 2006年
Seung-Hee Maeng, Hai-Won Chung, Ⅱ-je yu, Hyeon-Yeong Kim, Cheol-Hong Lim, Kwang-Jong Kim, Soo-Jin Kim, Ootsuyama, Y.,Kasai,H. Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent ch・・・

Mutation Research (539) 109-116 2003年
Kasai,H. A new automated method to analyze urinary 8-hydroxydeoxyguanosine by a high-performance liquid chromatography-electrochemmical detector system

J.Radiat.Res 44(2) 185-189 2003年
Kasai,H. A new automated method to analyze urinary 8-hydroxydeoxyguanosine by a high-performance liquid chromatography-electrochemmical detector system

HIROSHI KASAI

J.Radiat.Res 44(2) 185-189 2003年
Seung-Hee Maeng, Hai-Won Chung, Ⅱ-je yu, Hyeon-Yeong Kim, Cheol-Hong Lim, Kwang-Jong Kim, Soo-Jin Kim, Ootsuyama, Y.,Kasai,H. Changes of 8-OH-dG levels in DNA and its base excision repair activity in rat lungs after inhalation exposure to hexavalent ch・・・

Mutation Research (539) 109-116 2003年
The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently by the Escherichia coli recombinant Orf1.35 protein

K Fujikawa, H Kasai

DNA REPAIR 1(7) 571-576 2002年7月
Mei,N.,Kunugita,N.,Hirano,T.,and Kasai,H. Acute aresenite-induced 8-hydroxyguanine is associated with inhibition of repair activity cultured human cells

MEI N, KUNUGITA N, HIRANO T, KASAI H

Biochemical and Biophysical Research Communications 297(4) 924-930 2002年
Mei,N.,Kunugita,N.,Hirano,T.,and Kasai,H. Acute aresenite-induced 8-hydroxyguanine is associated with inhibition of repair activity cultured human cells

Biochemical and Biophysical Research Communications 297(4) 924-930 2002年
Urinary 8-Oxo-7, 8-dihydro-2'-deoxyguanosine Values measured by an ELISA correlated well with measurements by high-performance liquid chromatography with electrochemical detection.

Cancer Epidemiol Biomaekers Prev. 11(1076-81) 2002年
8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog.

FEBS Letters 512(149-151) 2002年

もっとみる

書籍等出版物

3

Increased 8-OH-Gua in DNA and its repair activity in crocidolite treated hamster lung.

In "Advances in the Prevention of Occupational Respiratory Diseases"(des. , K. Chiyotani, et al), Elsevier Science B. V. 1998年
Increased 8-hydroxyguanine repair activity in animal livers and human leukocytes induced by oxidative stress : Effects of diet, physical exercise, and cigarette smoking.

In "┣DBFood Factors for Cancer Prevention(/)-┫DB" Springer-Verlag Tokyo 1997年
"Formation of 8-hydroxyguanine in DNA by aging and oxidative stress"(共著)

Oxidative Stress and Aging 1995年

所属学協会

6

共同研究・競争的資金等の研究課題

2