論文

査読有り
2016年1月

Amino acid substitutions in the heptad repeat A and C regions of the F protein responsible for neurovirulence of measles virus Osaka-1 strain from a patient with subacute sclerosing panencephalitis

VIROLOGY
  • Minoru Ayata
  • ,
  • Miyuu Tanaka
  • ,
  • Kazuo Kameoka
  • ,
  • Mitsuru Kuwarnura
  • ,
  • Kaoru Takeuchi
  • ,
  • Makoto Takeda
  • ,
  • Kazuhiko Kanou
  • ,
  • Hisashi Ogura

487
開始ページ
141
終了ページ
149
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.virol.2015.10.004
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Measles virus (MV) is the causative agent of subacute sclerosing panencephalitis (SSPE). We previously reported that the F gene of the SSPE Osaka-2 strain is the major determinant of MV neurovirulence. Because the sites and extents of mutations differ among SSPE strains, it is necessary to determine the mutations responsible for the SSPE-specific phenotypes of individual viral strain. In this study, recombinant viruses containing the envelope-associated genes from the SSPE Osaka-1 strain were generated in the IC323 wild-type MV background. Hamsters inoculated with MV containing the H gene of the Osaka-1 strain displayed hyperactivity and seizures, but usually recovered and survived. Hamsters inoculated with MV containing the F gene of the Osaka-1 strain displayed severe neurologic signs and died. Amino acid substitutions in the heptad repeat A and C regions of the F protein, including a methionine-to-valine substitution at amino acid 94, play major roles in neurovirulence. (C) 2015 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1016/j.virol.2015.10.004
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000366438500016&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.virol.2015.10.004
  • ISSN : 0042-6822
  • Web of Science ID : WOS:000366438500016

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