論文

2014年8月

Biased hypermutation occurred frequently in a gene inserted into the IC323 recombinant measles virus during its persistence in the brains of nude mice

VIROLOGY
  • Sanae Otani
  • ,
  • Minoru Ayata
  • ,
  • Kaoru Takeuchi
  • ,
  • Makoto Takeda
  • ,
  • Haruo Shintaku
  • ,
  • Hisashi Ogura

462
開始ページ
91
終了ページ
97
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.virol.2014.05.035
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Measles virus (MV) is the causative agent of measles and its neurological complications, subacute sclerosing panencephalitis (SSPE) and measles inclusion body encephalitis (MIBE). Biased hypermutation in the M gene is a characteristic feature of SSPE and MIBE. To determine whether the M gene is the preferred target of hypermutation, an additional transcriptional unit containing a humanized Renilla reniformis green fluorescent protein (hrGFP) gene was introduced into the IC323 MV genome, and nude mice were inoculated intracerebrally with the virus. Biased hypermutation occurred in the M gene and also in the hrGFP gene when it was inserted between the leader and the N gene, but not between the El and L gene. These results indicate that biased hypermutation is usually found in a gene whose function is not essential for viral proliferation in the brain and that the location of a gene in the MV genome can affect its mutational frequency. (C) 2014 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1016/j.virol.2014.05.035
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000340225100010&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.virol.2014.05.035
  • ISSN : 0042-6822
  • Web of Science ID : WOS:000340225100010

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