論文

2011年7月

Remarkable similarity in genome nucleotide sequences between the Schwarz FF-8 and AIK-C measles virus vaccine strains and apparent nucleotide differences in the phosphoprotein gene

MICROBIOLOGY AND IMMUNOLOGY
  • Chie Ito
  • ,
  • Shinji Ohgimoto
  • ,
  • Seiichi Kato
  • ,
  • Luna Bhatta Sharma
  • ,
  • Minoru Ayata
  • ,
  • Katsuhiro Komase
  • ,
  • Kaoru Takeuchi
  • ,
  • Toshiaki Ihara
  • ,
  • Hisashi Ogura

55
7
開始ページ
518
終了ページ
524
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/j.1348-0421.2011.00339.x
出版者・発行元
WILEY-BLACKWELL

The Schwarz FF-8 (FF-8) and AIK-C measles virus vaccine strains are currently used for vaccination in Japan. Here, the complete genome nucleotide sequence of the FF-8 strain has been determined and its genome sequence found to be remarkably similar to that of the AIK-C strain. These two strains are differentiated only by two nucleotide differences in the phosphoprotein gene. Since the FF-8 strain does not possess the amino acid substitutions in the phospho-and fusion proteins which are responsible for the temperature-sensitivity and small syncytium formation phenotypes of the AIK-C strain, respectively, other unidentified common mechanisms likely attenuate both the FF-8 and AIK-C strains.


リンク情報
DOI
https://doi.org/10.1111/j.1348-0421.2011.00339.x
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000292164400009&DestApp=WOS_CPL
ID情報
  • DOI : 10.1111/j.1348-0421.2011.00339.x
  • ISSN : 0385-5600
  • Web of Science ID : WOS:000292164400009

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